AI Summary & Key Takeaways
AI InsightConclusions: There seem to be associations between certain HLA antigens and susceptibility to autoimmune hepatitis, but variations among different geographical locations suggest a role for environmental factors.
📌 3 Key Takeaways
Abstract
Background/aims: We aimed to identify the genetic factors associated with increased tendency toward autoimmune hepatitis, a chronic and progressive inflammatory condition. Methods: A total of 32 children diagnosed with autoimmune hepatitis were included in the present study, and 160 healthy adult blood donors served as controls. In both groups, HLA phenotypes were examined (HLA-A, B, C, DR, DQ) and compared. In addition, the association between the type of autoimmune hepatitis and HLA status was explored. Results: Compared to controls, patients with autoimmune hepatitis had increased frequencies of the following class 1 HLA antigens: A24.9 (28% vs. 9%, p=0.007), A26 (25% vs. 3%, p<0.001), A32 (34% vs. 4%, p<0.001), B38 (9% vs. 0.6%, p=0.015), and B51 (16% vs. 0%, p<0.001). Among class II HLA antigens, DRB1*04 (22% vs. 0%, p<0.001), DRB1*07 (9% vs. 0%, p=0.004), DRB1*11 (12% vs. 0%, p=0.001), DRB1*15 (25% vs. 0%, p<0.001), DRB1*14 (31% vs. 0%, p<0.001), and DR11.5 (9% vs. 0%, p=0.004) were more frequent in patients compared to controls. Type 1 autoimmune hepatitis was associated with high frequencies of A24.9, A26, A32, and DRB1*15, whereas type 2 autoimmune hepatitis was associated with high frequencies of A26, B51, B38, and DRB1*11. On the other hand, frequencies of A32 and DRB1*04 were high among patients with unclassified autoimmune hepatitis. Conclusions: There seem to be associations between certain HLA antigens and susceptibility to autoimmune hepatitis, but variations among different geographical locations suggest a role for environmental factors.
Özet
Amaç: Kronik ve ilerleyici inflamatuar bir durum olan otoimmun hepatite yatkınlığı arttıran genetik faktörlerin belirlenmesi. Yöntem: Otoimmun hepatit tanılı toplam 32 hasta ile sağlıklı, adült 160 kan vericisi kontrol grubu olarak çalışmaya alınmıştır. Her iki grupta HLA fenotipleri (HLA-A, B, C, DR, DQ) incelenmiş ve karşılaştırılmıştır. Otoimmun hepatit tipleri ile HLA durumu arasındaki ilişki araştırılmıştır. Bulgular: Otoimmun hepatitli hastalarla kontrol grubu karşılaştırıldığında Class-1 HLA antijenleri artmış sıklıkta bulunmuştur: A24.9 (28% vs. 9%, p=0.007), A26 (37% vs. 3%, p=0.004), A32 (34% vs. 4%, p<0.001), B38 (9% vs. 0.6%, p=0.015) ve B51 (15% vs. 0%, p=0.026). Class-2 HLA antijenlerinden: DRB1*04 (21% vs. 0%, p<0.001), DRB1*07 (9% vs. 0%, p=0.004), DRB1*11 (12% vs. 0%, p=0.001), DRB1*15 (21% vs. 0%, p<0.001), DRB1*14 (31% vs. 0%, p<0.001) ve DR11.5 (9% vs. 0%, p=0.004) hastalarda kontrol grubuna göre daha sıktır. Tip 1 otoimmun hepatit artmış A24.9, A26, A32 ve DRB1*15; Tip 2 AIH A26, B51 ve DRB1*11 HLA sıklığı ile ilişkili bulunmuştur. A32 ve DRB1*04 sıklığı tanımlanmamış otoimmun hepatit hastalarında yüksek bulunmuştur. Sonuç: Belirli HLA antijenleri ile otoimmun hepatite yatkınlık arasında bir ilişki olduğu görülmektedir ancak coğrafik lokasyonlar gibi çevresel faktörler de etkili olmaktadır.