Journals / Turkish Journal of Gastroenterology / 2013 / Cilt: 24 - Sayı: 5

Determining the frequency and severity of malnutrition and correlating it with the severity of liver cirrhosis

Malnütrisyonun sıklığı ve ciddiyetinin değerlendirilmesi ve sirozun ciddiyetiyle ilişkisinin saptanması

Pages
415–422
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The degree of malnutrition increases with increasing clinical severity of cirrhosis of liver.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Background/aims: Malnutrition is a significant problem in cirrhosis of the liver worldwide.
📊
Key Findings & Data:The patients were categorized into well-nourished, and mild to moderately and severely malnourished.
💡
Conclusion & Impact:The degree of malnutrition increases with increasing clinical severity of cirrhosis of liver.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Background/aims: Malnutrition is a significant problem in cirrhosis of the liver worldwide. Inadequate data is available on the nutritional status of Pakistani patients. This study aimed to determine the frequency and severity of malnutrition in patients ha- ving cirrhosis of the liver and to compare the degree of malnutrition with the severity of liver disease. Materials and Methods: Two hundred ninety-eight patients with liver cirrhosis were included in the study. Nutritional status was assessed using the Royal Free Hospital Global Assessment scheme for cirrhotics. The patients were categorized into well-nourished, and mild to moderately and severely malnourished. Various degrees of malnutrition were compared with severity of disease according to Child-Pugh sta- ging. Results: In the 298 patients with liver cirrhosis, hepatitis C (54,36%) and B (35,90%) were the commonest aetiologies, follo- wed by autoimmune hepatitis (3,35%), primary billiary cirrhosis (2,34%), Wilson's disease (1,34%), haemochromatosis (1,0%), cryptogenic cirrhosis (1,0%), and alcohol being the rare cause (0,67%). 14,42% patients were well-nourished, (54,02%) were mild to moderately malnourished and (31,54%) were severely malnourished. Malnutrition is more frequent in virus-related cirrhosis, and the degree of malnutrition increases with increasing clinical severity as assessed by Child- Pugh stages with statistically significant p-value of 0.001. Conclusion: Moderate to severe malnutrition among diverse aetiologies of cirrhosis is quite common in Pakistan. The degree of malnutrition increases with increasing clinical severity of cirrhosis of liver.

Özet

Girifl ve Amaç: Malnütrisyon karaciğer sirozunda dünya çapında bir problemdir. Pakistan'lı hastaların beslenme durumları ile ilgili veriler de yetersizdir. Bu çalıflmada karaciğer sirozlu hastalarda malnütrisyonun sıklık ve ciddiyetinin değerlendirilmesi ve karaciğer hastalığının ciddiyetiyle malnütrisyon derecesinin karflılafltırılması amaçlanmıfltır. Gereç ve Yöntem: Karaciğer siroz- lu 298 hasta çalıflmaya alındı. Beslenme durumları, sirozlular için Royal Free Hospital Global Assessment fleması kullanılarak de- ğerlendirildi. Hastalar, iyi beslenmifl, hafif, orta ve ciddi malnütrisyon olarak kategorize edildi. Malnütrisyon dereceleri ile Child Pugh evrelemesine göre hastalık dereceleri karflılafltırıldı. Bulgular: Karaciğer sirozlu 298 hastanın etyolojileri değerlendirildiğin- de; hepatit C (%54,36) ve B (%35,90) en sık nedenlerdi, bunu takiben otoimmün hepatit (%3,35), primer biliyer siroz (%2,34), Wil- son hastalığı (%1,34), hemokromatoz (%1,0), kriptojenik siroz (%1,0) ve alkol en nadir nedendi (%0,67). Hastaların %14,42'si iyi beslenmifl, %54,02'si hafif veya orta malnütrisyone ve %31,54'ü ciddi malnütrisyone idi. Sonuç: Pakistanda sirozun genifl etyolo- jik spektrumunda orta ve ciddi malnütrisyon gayet sık görülmektedir. Sirozun klinik ciddiyeti arttıkça malnütrisyonun derecesi de artmaktadır.

🔖

Cite This Article

NAQVI, I. H., MAHMOOD, K., AKHTER, S. T. (2013). Determining the frequency and severity of malnutrition and correlating it with the severity of liver cirrhosis. Turkish Journal of Gastroenterology, Cilt: 24 - Sayı: 5, 415–422. https://ajindex.com/articles/409640

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (15)

  1. Kondrup J. Nutrition in end stage liver disease. Best Pract Res Clin Gastroenterol 2006; 20:547-60
  2. Campillo B, Richardet JF, Bories PN. Validation of body mass index for the diagnosis of malnutrition in patients with liver cirrhosis. Gastroenterol Clin Biol 2006; 30: 1137-43
  3. Kalaitzakis E, Simren M, Olsson R, et al. Gastrointestinal symptoms in patients with liver cirrhosis: associations with nutritional status and health-related quality of life. Scand J Gastroenterol 2006; 41:1464-72
  4. Guglielmi FW, Panella C, Buda A, et al. Nutritional state and energy balance in cirrhotic patients with or without hypermetabolism. Multicentre prospective study by the 'Nutritional Problems in Gastroenterology' Section of the Italian Society of Gastroenterology (SIGE). Dig Liver Dis 2005; 37:681-8
  5. Gunsar F, Riamondo ML, Jones S, et al. Nutritional status and prognosis in cirrhotic patients. Aliment Pharmacol Ther 2006; 24:563-72
  6. Campillo B, Richardet JP, Bories PN. Enteral nutrition in severely malnourished and anorectic cirrhotic patients in clinical practice. Gastroenterol Clin Biol 2005; 29:645-51
  7. Izbeki F, Kiss I, Wittmann T, et al. Impaired accommodation of proximal stomach in patients with alcoholic liver cirrhosis. Scand J Gastroenterol 2002; 37:1403-10
  8. Gunnarsdottir SA, Sadik R, Shev S, et al. Small intestinal motility disturbances and bacterial overgrowth in patients with liver cirrhosis and portal hypertension. Am J Gastroenterol 2003; 98:1362-70
  9. Gundling F, Teich N, Strebel HM, et al. Ernahrung bei leberzirrhose. Med Klin 2007; 102:435-44
  10. Alberino F, Gatta A, Amodio P, et al. Nutrition and survival in patients with liver cirrhosis. Nutrition 2001; 17:445-50
  11. Plauth M, Cabre E, Riggio O, et al. ESPEN guidelines on enteral nutrition: liver disease. Clin Nutr 2006; 25:285-94
  12. Morgan, MY, Madden AM, Soulsby CT, Morris RW. Derivation and validation of a new global method for assessing nutritional status in patients with cirrhosis. Hepatology 2006; 44:823-35
  13. Jones JM. Reliability of nutritional screening and assessment tools. Nutrition 2004; 20:307-11
  14. Mendenhall CL. Protein-calorie malnutrition in alcoholic liver disease. In: Watson RR, Watz lB, eds. Nutrition and Alcohol. Boca Raton FL. CRC Press, 1992: 363-84
  15. Food composition tables for Pakistan, 2001. Department of Agriculture Chemistry NWFP Agricultural University Peshawar, UNICEF Islamabad, Ministry of Planning and Development Government of Pakistan Isl