AI Summary & Key Takeaways
AI InsightNo statistically significant correlation was found between the HLA tissue groups and diarrhea(p=0.087), osteoporosis (p=0.215), anemia (p=1.000), tissue transglutaminase antibodies (p=0.295), anti-gliadin antibodies (p=0.104),and anti-endomysium antibodies (p=0.243) in the celiac patient group.Conclusion: HLA-DQ2/DQ8 can be used to diagnose celiac disease particularly when the tests are useless and to screen first-degreerelatives.
📌 3 Key Takeaways
Özet
Background/Aims: Celiac disease is an autoimmune, familial disease that results in susceptibility to gluten in cereal and cereal productsin genetically susceptible individuals. The aim of the present study was to investigate the presence of HLA-DQ2/DQ8 in patients withceliac disease, their first-degree relatives, and healthy community.Materials and Methods: HLA-DQ2/DQ8 analysis was performed in adult patients with celiac disease ≥18 years old (94 patients), theirfirst-degree relatives (89 people), and healthy group (102 individuals). Anemia, osteoporosis, and diarrhea were interrogated in the celiacpatient group and also anti-tissue transglutaminase, anti-endomysium, and anti-gliadin antibodies were recorded.Results: There was a significant relationship between HLA-DQ2/DQ8 presence in all groups, and the distribution of HLA-DQ2/DQ8in all groups was different (p=0.000). No statistically significant correlation was found between the HLA tissue groups and diarrhea(p=0.087), osteoporosis (p=0.215), anemia (p=1.000), tissue transglutaminase antibodies (p=0.295), anti-gliadin antibodies (p=0.104),and anti-endomysium antibodies (p=0.243) in the celiac patient group.Conclusion: HLA-DQ2/DQ8 can be used to diagnose celiac disease particularly when the tests are useless and to screen first-degreerelatives.