AI Summary & Key Takeaways
AI InsightFurthermore, we performed a reviewof literature to compile previously reported entecavir-associated drug reactions.
📌 3 Key Takeaways
Özet
Fixed drug eruption (FDE) is a type of drug reaction characterized by localized erythema, hyperpigmentation, and bullous at the samesite(s), generally observed following every intake of a causative drug. Delayed-type cellular hypersensitivity (Type IVC) is considered toplay a role in FDE etiology. Several antibiotics, barbiturates, oral contraceptives, nonsteroidal anti-inflammatory drugs, laxative-containing phenolphthalein, metronidazole, and quinine are known to be the primary drugs responsible for FDE. Bullous FDE, on the otherhand, is a relatively rare form of FDE. Hepatitis B is a significant worldwide health problem, and entecavir is a common nucleoside(deoxyguanosine) analog used for treating hepatitis B; however, it has various side effects, such as lactic acidosis, myalgia, azotemia,hypophosphatemia, headache, diarrhea, pancreatitis, and neuropathy, and, in rare cases, cutaneous drug eruption. Our aim is to presenta case of entecavir-associated bullous drug reaction, which has not been reported in the literature. Furthermore, we performed a reviewof literature to compile previously reported entecavir-associated drug reactions.