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Journals / Türk Dermatoloji Dergisi / 2019 / Cilt: 13 - Sayı: 4

Thiol/Disulfide Homeostasis in Patients with Telogen Effluvium: Is Oxidative Stress Important in the Pathogenesis of Telogen Effluvium?

Unsal SAVCI
Mustafa Fethi ŞAHİN
Engin ŞENEL
Aynure ÖZTEKİN
Umran MUSLU
Mustafa SUNGUR
Salim NESELİOĞLU
Özcan EREL
Pages
131–134
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There is a need for new studies that will show the possible effects of OS on TE pathogenesis and research different OS markers in addition to thiol/disulfide parameters.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: The aim of this study was to assess the correlation between telogen effluvium (TE) with the new oxidative stress (OS) indicator of thiol/disulfide balance and to research the role of OS in the pathogenesis of TE.
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Key Findings & Data:Methods: Our study included 101 patients with TE diagnosis and 39 healthy individuals.
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Conclusion & Impact:There is a need for new studies that will show the possible effects of OS on TE pathogenesis and research different OS markers in addition to thiol/disulfide parameters.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objective: The aim of this study was to assess the correlation between telogen effluvium (TE) with the new oxidative stress (OS) indicator of thiol/disulfide balance and to research the role of OS in the pathogenesis of TE. Methods: Our study included 101 patients with TE diagnosis and 39 healthy individuals. Serum thiol/disulfide was measured with a new automated spectrometric method developed by Erel and Neselioglu, and results were compared statistically. Results: Among the six thiol/disulfide parameters, there were statistically significant differences for native thiol, total thiol, disulfide, disulfide/native thiol, disulfide/total thiol, and native thiol/total thiol studied in the patient and control groups (P = 0.042, 0.044, <0.001, 0.013, 0.026, and < 0.001, respectively). Conclusions: Based on the results of this study, it can be said that OS is closely associated with TE pathogenesis. There is a need for new studies that will show the possible effects of OS on TE pathogenesis and research different OS markers in addition to thiol/disulfide parameters.

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Cite This Article

SAVCI, U., ŞAHİN, M. F., ŞENEL, E., ÖZTEKİN, A., MUSLU, U., SUNGUR, M., NESELİOĞLU, S., EREL, Ö. (2019). Thiol/Disulfide Homeostasis in Patients with Telogen Effluvium: Is Oxidative Stress Important in the Pathogenesis of Telogen Effluvium?. Türk Dermatoloji Dergisi, Cilt: 13 - Sayı: 4, 131–134. https://ajindex.com/articles/409131

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