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Journals / Türk Geriatri Dergisi / 2021 / Cilt: 24 - Sayı: 4

THE EFFECTS OF THIAZIDE AND THIAZIDELIKE DIURETICS ON THE RELATIONSHIP BETWEEN NORMAL SERUM URIC ACID LEVELS AND COGNITIVE FUNCTION

Fatma Özge Kayhan KOÇAK
Seval AY
Mehmet Zuhuri ARUN
Sevnaz ŞAHİN
Zeliha Fulden SARAÇ
Selahattin Fehmi AKÇİÇEK
Elif ERTUNA
Pages
526–533
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Low serum uric acid levels are associated with cognitive impairment; a slight but significant increase of serum uric acid due to thiazide diuretic use does not seem to enhance cognitive function in geriatric patients.

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Objective & Hypothesis:Introduction: The objective of this study was to identify the possible effect of thiazide and thiazide-like diuretic use on the relationship between uric acid and cognitive function in geriatric patients with normal renal function.
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Key Findings & Data:Method: Serum uric acid levels and Mini-Mental State Examination scores of 238 patients (age ≥65 years) treated in an outpatient geriatric clinic were evaluated in this observational, cross-sectional, retrospective study.
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Conclusion & Impact:Conclusions: Low serum uric acid levels are associated with cognitive impairment; a slight but significant increase of serum uric acid due to thiazide diuretic use does not seem to enhance cognitive function in geriatric patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Introduction: The objective of this study was to identify the possible effect of thiazide and thiazide-like diuretic use on the relationship between uric acid and cognitive function in geriatric patients with normal renal function. Method: Serum uric acid levels and Mini-Mental State Examination scores of 238 patients (age ≥65 years) treated in an outpatient geriatric clinic were evaluated in this observational, cross-sectional, retrospective study. The effect of thiazide diuretic use on Mini-Mental State Examination score was also assessed. Results: Compared to patients that are not currently taking thiazide diuretics (non-thiazide group) serum uric acid was significantly higher in patients using thiazide and thiazide-like diuretics (thiazide group) (5.27±0.12 vs 6.09±0.20; P< 0.001). Although the serum uric acid levels were higher in the thiazide group the Mini-Mental State Examination scores were similar to the non-thiazide group. There was a strong positive correlation between serum uric acid levels and Mini-Mental State Examination score in both groups (P< 0.001). The Mini-Mental State Examination score was significantly lower in the lowest serum uric acid quartile in both groups (P< 0.001). Conclusions: Low serum uric acid levels are associated with cognitive impairment; a slight but significant increase of serum uric acid due to thiazide diuretic use does not seem to enhance cognitive function in geriatric patients.

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Cite This Article

KOÇAK, F. Ö. K., AY, S., ARUN, M. Z., ŞAHİN, S., SARAÇ, Z. F., AKÇİÇEK, S. F., ERTUNA, E. (2021). THE EFFECTS OF THIAZIDE AND THIAZIDELIKE DIURETICS ON THE RELATIONSHIP BETWEEN NORMAL SERUM URIC ACID LEVELS AND COGNITIVE FUNCTION. Türk Geriatri Dergisi, Cilt: 24 - Sayı: 4, 526–533. https://ajindex.com/articles/409067

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