AI Summary & Key Takeaways
AI InsightAnd for women with the HBV viral loads lower than 106 copies/mL,we suggest clinicians to examine the use of lamivudine on a case-to-case basis, noting that lamivudine seems to be a safe drug for themother and the fetus
📌 3 Key Takeaways
Özet
Background/Aims: Mother-to-child transmission (MTCT) is a common transmission mode of hepatitis B virus (HBV). It has been shownthat the infection may occur in some infants despite the use of immunoprophylaxis, and many studies have demonstrated the efficacyof antivirals such as lamivudine to reduce such events.Materials and Methods: A meta-analysis was conducted concerning the efficacy and safety of lamivudine during pregnancy, in theprevention of vertical transmission of HBV infection. Studies were identified by searching various databases up to January 2016 for variations of the following phrase: “lamivudine AND (pregnancy or pregnant) AND (HBV or hepatitis).” Subjects who had received lamivudinewere included in the case group, and those who had not were included in the control group.Results: Our search identified a total number of 881 citations, of which 25 studies (with a total number of 2,667 pregnant women) wereincluded in the meta-analysis. The analysis showed a significant difference between the seropositive HBsAg infants from the case andcontrol groups (RR= 16.97, 95% confidence interval 8.36-34.45), which is the most critical factor in determining the MTCT of HBV. Nosignificant difference was reported between the prevalence of side effects in the case and control groups.Conclusion: This meta-analysis strongly suggests the use of lamivudine in the prevention of HBV vertical transmission in carrier pregnant women with the HBV DNA levels greater than 106 copies/mL. And for women with the HBV viral loads lower than 106 copies/mL,we suggest clinicians to examine the use of lamivudine on a case-to-case basis, noting that lamivudine seems to be a safe drug for themother and the fetus