Journals / The Journal of Pediatric Research / 2021 / Cilt: 8 - Sayı: 2

Benign Early Repolarization Pattern: Is it Really Benign for Children?

Pages
171–175
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: These findings suggest that benign ER in children is associated with the risk of arrhythmogenesis through alterations in ventricular repolarization.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Aim: Early repolarization (ER) is a common electrocardiographic (ECG) finding.
📊
Key Findings & Data:Materials and Methods: The study group included 56 healthy children with a benign ER pattern on ECG and a control group was formed of 81 children with normal ECG.
💡
Conclusion & Impact:Conclusion: These findings suggest that benign ER in children is associated with the risk of arrhythmogenesis through alterations in ventricular repolarization.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Aim: Early repolarization (ER) is a common electrocardiographic (ECG) finding. Although it is thought to be a benign phenomenon, recent studies have shown it to be an important marker of cardiac vulnerability, which can lead to sudden cardiac death. However, there are still conflicting data regarding the prognostic significance of ER in asymptomatic subjects, especially in children. The aim of this study was to investigate specific ECG markers that reflect ventricular repolarization in children with benign ER. Materials and Methods: The study group included 56 healthy children with a benign ER pattern on ECG and a control group was formed of 81 children with normal ECG. Benign ER pattern was defined as terminal QRS notching or slurring accompanied by rapidly ascending ST elevation (>0.1 mV from baseline) in two or more leads. The ECG parameters of QT dis, QTc dis, Tpe dis, Tp-e/QT and Tp-e/QTc were evaluated at rest by a single experienced pediatric cardiologist blinded to the groups. Results: Higher Tp-e, Tp-e dis, Tp-e/QT and Tp-e/QTc measurements were determined in the study group than in the control group. There were no significant differences in the studied ECG parameters with respect to ER location (inferior, lateral, inferolateral), or the ER type (slurring, notching or both). Conclusion: These findings suggest that benign ER in children is associated with the risk of arrhythmogenesis through alterations in ventricular repolarization.

🔖

Cite This Article

KAYALI, Ş., DEMİR, F., KOÇAK, M., KARADENİZ, C. (2021). Benign Early Repolarization Pattern: Is it Really Benign for Children?. The Journal of Pediatric Research, Cilt: 8 - Sayı: 2, 171–175. https://ajindex.com/articles/407368

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (16)

  1. Obeyesekere MN, Klein GJ, Nattel S, et al., A clinical approach to early repolarization. Circulation 2013; 127:1620-9
  2. De Ambroggi L, Sorgente A, De Ambroggi G. Early repolarization pattern: innocent finding or marker of risk? J Electrocardiol 2013; 46:297-301
  3. Ahmed H, Czosek RS, Spar DS, et al. Early repolarization in normal adolescents is common. Pediatr Cardiol 2017; 38:864-72
  4. Benito B, Guasch E, Rivard L, et al. Clinical and mechanistic issues in early repolarization of normal variants and lethal arrhythmia syndromes. J Am Coll Cardiol 2010; 56:1177-86
  5. Haissaguerre M, Derval N, Sacher F, et al. Sudden cardiac arrest associated with early repolarization. N Engl J Med 2008; 358:2016-23
  6. Tikkanen JT, Huikuri HV. Characteristics of “malignant” vs. “benign” electrocardiographic patterns of early repolarization. J Electrocardiol 2015; 48:390-4
  7. Perez-Riera AR, Abreu LC, Yanowitz F, et al. “Benign” early repolarization versus malignant early abnormalities: clinicalelectrocardiographic distinction and genetic basis. Cardiol J 2012; 19:337-46
  8. Merchant FM, Noseworthy PA, Weiner RB, et al. Ability of terminal QRS notching to distinguish benign from malignant electrocardiographic forms of early repolarization. Am J Cardiol 2009; 104:1402-6
  9. Kors JA, Ritsema van Eck HJ, van Herpen G. The m eaning of the Tp-Te interval and its diagnostic value. J Electrocardiol 2008; 41:575-80
  10. Gupta P, Patel C, Patel H, et al. T(p-e)/QT ratio as an index of arrhythmogenesis. J Electrocardiol 2008; 41:567-74
  11. Reinhard W, Trenkwalder T, Haller B, et al., The early repolarization pattern: echocardiographic characteristics in elite athletes. Ann Noninvasive Electrocardiol 2019; 24:e12617. doi: 10.1111/anec.12617
  12. Tikkanen JT, Juntilla MJ, Anttonen O, et al. Early repolarization: electrocardiographic phenotypes associated with favorable long-term outcome. Circulation 2011; 123:2666-73
  13. Antzelevitch C, Yan GX. Cellular and ionic mechanisms responsible for the Brugada syndrome. J Electrocardiol 2000; (Suppl 33):33-9
  14. Karadeniz C, Özdemir R, Demirol M, et al. Low Iron Stores in Otherwise Healthy Children Affect Electrocardiographic Markers of Important Cardiac Events. Pediatr Cardiol 2017; 38:909-14
  15. Tikkanen JT, Anttonen O, Juntilla MJ, et al. Long-term outcome associated with early repolarization on electrocardiography. N Engl J Med 2009; 361:2529-37
  16. Letsas KP, Charalampous C, Koantzopoulos P, et al., Novel indexes of heterogen