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Journals / Experimental Biomedical Research / 2021 / Cilt: 4 - Sayı: 4

The relationship of serum asymmetric dimethylarginine concentrations and lung involvement in patients with COVID-19 infection

Nadir EMLEK
Ahmet Seyda YILMAZ
Elif ERGÜL
Hasan GÜNDOĞDU
Medeni ARPA
Haldun KOÇ
Muhammet ÖZTÜRK
Cihan AYDIN
Pages
314–321
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: We revealed elevated ADMA concentrations as the surrogate of endothelial dysfunction in COVID-19 patients whether they have pneumonia or not.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: COVID-19 infections the tissue through angiotensin converting enzyme 2 receptor, which is also expressed on endothelial cells.
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Key Findings & Data:The aim of our study was to evaluate ADMA concentrations and to identify its association with lung involvement in patients with COVID 19 disease.
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Conclusion & Impact:Conclusion: We revealed elevated ADMA concentrations as the surrogate of endothelial dysfunction in COVID-19 patients whether they have pneumonia or not.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Aim: COVID-19 infections the tissue through angiotensin converting enzyme 2 receptor, which is also expressed on endothelial cells. Endothelial dysfunction may be associated with lung involvement. Asymmetric dimethylarginine (ADMA) is an indirect marker of endothelial dysfunction. The aim of our study was to evaluate ADMA concentrations and to identify its association with lung involvement in patients with COVID 19 disease. Methods: We included 42 patients with COVID-19 infection and lung involvement (Group 1). Forty-two age and sex matched patients without pneumonia acted as the control group (Group 2). All patients gave blood samples for ADMA at the 1st month control visit after discharge. We compared C-reactive protein (CRP) and ADMA concentrations in addition to routine biochemical parameters between groups. Results: Patients with lung involvement had higher admission glucose, CRP, and ADMA concentrations, and displayed lower hemoglobin concentration and lymphocyte count compared to patients without lung involvement. Although patients with lung involvement had higher ADMA concentrations with respect to those without; plasma ADMA levels were also higher than normal values in control group. Multivariate analysis identified log CRP concentration (OR= 3.047, 95% CI=1.881-5.023, p<0.001) as the independent predictor for lung involvement. And, there was a correlation between ADMA and CRP (r: 0.318, p: 0.003). Conclusion: We revealed elevated ADMA concentrations as the surrogate of endothelial dysfunction in COVID-19 patients whether they have pneumonia or not.

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Cite This Article

EMLEK, N., YILMAZ, A. S., ERGÜL, E., GÜNDOĞDU, H., ARPA, M., KOÇ, H., ÖZTÜRK, M., AYDIN, C. (2021). The relationship of serum asymmetric dimethylarginine concentrations and lung involvement in patients with COVID-19 infection. Experimental Biomedical Research, Cilt: 4 - Sayı: 4, 314–321. https://ajindex.com/articles/407202

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References (16)

  1. Park SE. Epidemiology, virology, and clinical features of severe acute respiratory syndrome -coronavirus-2 (SARS-CoV-2
  2. Coronavirus Disease-19). Clin Exp Pediatr. 2020
  3. 63(4):119-24. [2]World Health organization
  4. WCDCCoronavirus Disease (COVID-19) Dashboard [updated 05/09/2020. [3]Wu Z, McGoogan JM. Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China: summary of a report of 72 314 cases from the Chinese Center for Disease Control and Prevention. JAMA. 2020
  5. :1239- 42. [4]Ferrario CM, Jessup J, Chappell MC, et al. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005
  6. :2605-10. [5]Flammer AJ, Anderson T, Celermajer DS, et al. The assessment of endothelial function: from research into clinical practice. Circulation. 2012
  7. :753-67. [6]Cekmen M, Turgut M, Turkoz Y, et al. Nitric Oxide and Nitric Oxide Synthaze Physiologic and Pathologic Characterictics. T Klin J Ped. 2001
  8. :226-35. [7]Raghavan SA, Dikshit M. Vascular regulation by the L-arginine metabolites, nitric oxide and agmatine. Pharmacol Res. 2004
  9. :397-14. [8]Varga Z, Flammer AJ, Steiger P, et al. Endothelial cell infection and endotheliitis in COVID-19. The Lancet. 2020
  10. :1417- 18. [9]Bonetti PO, Lerman LO, Lerman A. Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol. 2003
  11. 23(2):168-75. [10]Ciceri F, Beretta L, Scandroglio AM, et al Microvascular COVID-19 lung vessels obstructive thromboinflammatory syndrome (MicroCLOTS): an atypical acute respiratory distress syndrome working hypothesis. Crit Care Resusc. 2020
  12. 22(2):95-97. [11]Cooke JP. Derangements of the nitric oxide synthase pathway, L-arginine, and cardiovascular diseases. Circulation. 1997
  13. :379-82. [12]Napoli C, Ignarro LJ. Nitric oxide and atherosclerosis. Nitric Oxide. 2001
  14. :88- 97. [13]Nijveldt RJ, Teerlink T, Van Der Hoven B, Siroen MP, Kuik DJ, Rauwerda JA, van Leeuwen PA. Asymmetrical dimethylarginine (ADMA) in critically ill patients: high plasma ADMA concentration is an independent risk factor of ICU mortality. Clin Nutr. 2003
  15. 22(1):23-30. [14]Nijveldt RJ, Teerlink T, van Leeuwen PA. The asymmetrical dimethylarginine (ADMA)-multiple organ failure hypothesis. Clin Nutr. 2003
  16. 22(1):99-104. [15]Burgner DP, Sabin MA, Magnussen CG, et al. Early childhood hospitalisation with infection and subclinical atherosclerosis in adulthood: