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Journals / Turkish Journal of Medical Sciences / 2013 / Cilt: 43 - Sayı: 3

Serum interleukin-8, CA-125 levels, neutrophil-to-lymphocyte ratios, and combined markers in the diagnosis of endometriosis

Cemile DAYANGAN SAYAN
Müzeyyen Gülnur ÖZAKŞİT
Esma SARIKAYA
Pages
417–423
Publication Date
2013-03-01
DOI
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Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1.

📌 3 Key Takeaways

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Objective & Hypothesis:Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis.
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Key Findings & Data:Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis.
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Conclusion & Impact:Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Key words: Endometriosis · interleukin-8 · CA-125

Abstract

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1. The mean NLR, IL-8, and combined marker in patients with minimal to mild endometriosis were significantly higher than in patients without endometriosis, but the mean CA-125 was not. Conclusion: Measurements of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis.

Özet

Our aim was to investigate the usefulness of serum interleukin-8 (IL-8) and the neutrophil-to-lymphocyte ratio (NLR), either by themselves or as adjuncts to CA-125, in the diagnosis of various stages of endometriosis. Materials and methods: This study was a single-centre, prospective, group-comparative clinical trial. Serum IL-8 and the NLR, either alone or as adjuncts to CA-125, were analysed using receiver-operating characteristic (ROC) analysis to diagnose endometriosis. Fifty patients with endometriosis and 50 patients with benign ovarian cysts were included in this study. Results: The overall sensitivity and specificity of the combined markers for the detection of endometriosis were 80.0% and 86.0%, respectively, when using a cut-off value of 43.1. The mean NLR, IL-8, and combined marker in patients with minimal to mild endometriosis were significantly higher than in patients without endometriosis, but the mean CA-125 was not. Conclusion: Measurements of NLR and the combined marker may be used as simple and easily obtained diagnostic markers for endometriosis.

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Cite This Article

SAYAN, C. D., ÖZAKŞİT, M. G., SARIKAYA, E. (2013). Serum interleukin-8, CA-125 levels, neutrophil-to-lymphocyte ratios, and combined markers in the diagnosis of endometriosis. Turkish Journal of Medical Sciences, Cilt: 43 - Sayı: 3, 417–423. https://ajindex.com/articles/406588

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