Vagal Nerve Stimulation Effects on Generalized-Partial Seizures and Medication in Adult Drug-Resistant Epilepsy Patients

CONCLUSION: VNS is an alternative treatment option for drug resistant epilepsy for patients who are not ideal candidates for surgery or are not healed after epilepsy surgery

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: The aim of this study was to find out if vagal nerve stimulation (VNS) affect the generalized-partial seizure count and medical treatment in adult drug resistant epilepsy patients.

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Key Findings & Data:MATERIAL and METHODS: Twenty adult patients who were diagnosed with drug-resistant epilepsy were investigated retrospectively for vagal nerve stimulator implantation between 2001 and 2010 at the Neurosurgery Departments of ufuk university and Gulhane Military Medical Academy.

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Conclusion & Impact:CONCLUSION: VNS is an alternative treatment option for drug resistant epilepsy for patients who are not ideal candidates for surgery or are not healed after epilepsy surgery

🔬Design:Research Article

📍Scope:2001 Verileri

⚙️Variables:Domain Parameters

Özet

AIM: The aim of this study was to find out if vagal nerve stimulation (VNS) affect the generalized-partial seizure count and medical treatment in adult drug resistant epilepsy patients. MATERIAL and METHODS: Twenty adult patients who were diagnosed with drug-resistant epilepsy were investigated retrospectively for vagal nerve stimulator implantation between 2001 and 2010 at the Neurosurgery Departments of ufuk university and Gulhane Military Medical Academy. The effects of vagal nerve stimulation on generalized-partial seizures and medical treatment was scored and if a significant difference was found, a comparison was made by Wilcoxon Signed Ranks test and Pairwise. For all the group analyses, the statistical significant rank was accepted as a p value <0.05. Bonferroni correction was made when it was needed during pairwise comparisons. RESULTS: VNS significantly decreased the scores of generalized-partial seizures. There was no decrease in the doses of antiepileptic drugs and the medical treatment was resumed as before the implantation. The results were correlated with the relevant literature. CONCLUSION: VNS is an alternative treatment option for drug resistant epilepsy for patients who are not ideal candidates for surgery or are not healed after epilepsy surgery

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Cite This Article

ÖZDOĞAN, S., NURHAT, R. H., DÜZKALIR, A. H., YÜCE, D., SABUNCUOĞLU, H., GÖKÇİL, Z., ERDOĞAN, E. (2016). Vagal Nerve Stimulation Effects on Generalized-Partial Seizures and Medication in Adult Drug-Resistant Epilepsy Patients. Turkish Neurosurgery, Cilt: 26 - Sayı: 3, 347–351. https://ajindex.com/articles/405383

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