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Journals / Turkish Neurosurgery / 2017 / Cilt: 27 - Sayı: 1

The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model

Mehmet TOKMAK
Muserref Hilal SEHITOGLU
Yasemin YUKSEL
Mustafa GÜVEN
Tarık AKMAN
Adem Bozkurt ARAS
Umut YAKA
Cengiz GÖMLEKSİZ
Serdar Baki ALBAYRAK
Murat COŞAR
Pages
124–132
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.

📌 3 Key Takeaways

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Objective & Hypothesis:AIm: In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. mATERIAl and mEThODS: The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group.
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Key Findings & Data:Ischemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia.
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Conclusion & Impact:Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

AIm: In the relevant literature, there is no experimental study that investigated the axon protective effects of syringic acid- a polyphenol compound- with an anti-oxidant capacity on ischemia/reperfusion injury. mATERIAl and mEThODS: The rats were randomly divided into four groups: Control group (no medication or surgical procedure), Sham group, Syringic acid group, and Methyprednisolone (MP) Group. Ischemia was achieved by abdominal aorta clamping and all animals were sacrificed 24 hours after ischemia. Harvested sciatic nerve segments were investigated histopathologically and for tissue biochemistry. RESUlTS: Ischemic fiber degeneration scores were found significantly lower in syringic acid and MP groups than sham group. Additionally, apoptosis-related cysteine peptidase caspase-3 immunostaining scores were lower in syringic acid and MP groups. Biochemically, superoxide dismutase and nuclear respiratory factor 1 values were significantly higher in syringic acid group compared to those of control and sham groups while malondialdehyde levels were significantly lower in the syringic acid group. CONClUSION: Syringic acid reduces oxidative stress and axonal degeneration in rat sciatic nerve after ischemia/reperfusion injury. Therefore, syringic acid may play a role in the treatment of peripheral nerve injuries due to ischemia/reperfusion.

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Cite This Article

TOKMAK, M., SEHITOGLU, M. H., YUKSEL, Y., GÜVEN, M., AKMAN, T., ARAS, A. B., YAKA, U., GÖMLEKSİZ, C., ALBAYRAK, S. B., COŞAR, M. (2017). The Axon Protective Effects of Syringic Acid on Ischemia/ Reperfusion Injury in a Rat Sciatic Nerve Model. Turkish Neurosurgery, Cilt: 27 - Sayı: 1, 124–132. https://ajindex.com/articles/405370

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References (1)

  1. Abas F, Alkan T, Goren B: Neuroprotective effects of postconditioning on lipid peroxidation and apoptosis after focal cerebral ischemia/reperfusion injury in rats. Turk Neurosurg 20:1-8, 2010 2. Akdemir O, Akdemir I, Cavusoglu T, Lineaweaver WC, Ates U, Zhang F, Erbas O: Impact of aortic cross-clamping time on peripheral nerves: Experimental model. Ann Thorac Cardiovasc Surg 21(1):72-77, 2015 3. Ban M, Tonai T, Kohno T, Matsumoto K, Horie T, Yamamoto S, Moskowitz MA, Levine L: A flavonoid inhibitor of 5-lipoxygenase inhibits leukotriene production following ischemia in gerbil brain. Stroke 20:248-252, 1989 4. Bone DB, Antic M, Quinonez D, Hammond JR: Hypoxanthine uptake by skeletal muscle microvascular endothelial cells from equilibrative nucleoside transporter 1 (ENT1)-null mice: Effect of oxidative stress. Microvasc Res 98:16-22, 2015 5. Bors W, Heller W, Michel C, Saran M: Flavonoids as antioxidants: Determination of radical-scavenging efficiencies. Methods Enzymol 186: 343-355, 1990 6. Buege JA, Aust SD: Microsomal lipid peroxidation. Methods Enzymol 52: 302-310, 1978 7. Cassidy A, Brown JE, Hawdon A, Faughnan MS, King LJ, Millward J, Zimmer-Nechemias L, Wolfe B, Setchell KD: Factors affecting the bioavailability of soy isoflavones in humans after ingestion of physiologically relevant levels from different soy foods. J Nutr 136: 45-51, 2006 8. Grace PA: Ischaemia-reperfusion injury. Br J Surg 81:637- 647,1994 9. Hertog MGL, Hollman PCH, van de Putte B: Content of potentially anticarcinogenic flavonoids of tea infusions, wines, and fruit juices. J Agric Food Chem 41:1242-1246, 1993 10. Hwang YW, Kim SY, Jee SH, Kim YN, Nam CM: Soy food consumption and risk of prostate cancer: A meta-analysis of observational studies. Nutr Cancer 61: 598-606, 2009 11. Kang SS, Lee JY, Choi YK, Song SS, Kim JS, Jeon SJ, Han YN, Son KH, Han BH: Neuroprotective effects of naturally occurring biflavonoids. Bioorg Med Chem Lett 15:3588-3591, 2005 12. Kindy M: Inhibition of tyrosine phosphorylation prevents delayed neuronal death following cerebral ischemia. J Cereb Blood Flow Metab 13:372-377, 1993 13. Kumari S, Anderson L, Farmer S, Mehta SL, Li PA: Hyperglycemia alters mitochondrial fission and fusion proteins in mice subjected to cerebral ischemia and reperfusion. Transl Stroke Res 3:296-304, 2012 14. Li P, Nijhawan D, Budihardjo I, Srinivasula SM, Ahmad M, Alnemri ES, Wang X: Cytochrome C and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic p