SavedAdd your journal

Journals / Turkish Neurosurgery / 2018 / Cilt: 28 - Sayı: 5

The Research Progress of Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury

Gang LI
Yue YANG
Hua-Jiang DONG
Ling LIN
Pages
696–702
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In this article, we will review the characteristics of MSCs, MSCs for neuronal function restoration, the properties ofimmune-modulatory of MSCs, and the anti-apoptotic effects of MSCs, the angiogenesis effect of MSCs, and the safety issues inMSCs therapy in TBI.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in children and adults throughout the world.
📊
Key Findings & Data:It is urgentto ameliorate TBI damage and reduce the disability and case-fatality rate.
💡
Conclusion & Impact:In this article, we will review the characteristics of MSCs, MSCs for neuronal function restoration, the properties ofimmune-modulatory of MSCs, and the anti-apoptotic effects of MSCs, the angiogenesis effect of MSCs, and the safety issues inMSCs therapy in TBI.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Traumatic brain injury (TBI) is the leading cause of mortality and morbidity in children and adults throughout the world. It is urgentto ameliorate TBI damage and reduce the disability and case-fatality rate. Stem cell therapy is another medical revolution afterdrug and surgical medication. Mesenchymal stem cells (MSCs) are a class of cells with significant self-renewal and multi-lineagedifferentiation properties. They are favorable for the treatment of various diseases and injuries. It could be envisioned that MSCstransplantation may be a promising treatment for TBI. Currently, stem cell therapy has shown promising effects in the treatment ofmany diseases. In this article, we will review the characteristics of MSCs, MSCs for neuronal function restoration, the properties ofimmune-modulatory of MSCs, and the anti-apoptotic effects of MSCs, the angiogenesis effect of MSCs, and the safety issues inMSCs therapy in TBI.

🔖

Cite This Article

LI, G., YANG, Y., DONG, H., LIN, L. (2018). The Research Progress of Mesenchymal Stem Cells in the Treatment of Traumatic Brain Injury. Turkish Neurosurgery, Cilt: 28 - Sayı: 5, 696–702. https://ajindex.com/articles/405356

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Agrba VZ, Porkhanov VA, Karal-Ogly DD, Leontyuk AV, Kovalenko AL, Sholin IY, Gvozdik TE, Ignatova IE, Agumava AA, Chuguev YP, Gvaramiya IA, Lapin BA: Transplantation of simian mesenchymal stem cells to baboons with experimentally induced myocardial infarction. Bull Exp Biol Med 160: 589-591, 2016
  2. Ahmed AI, Shtaya AB, Zaben MJ, Owens EV, Kiecker C, Gray WP: Endogenous GFAP-positive neural stem/progenitor cells in the postnatal mouse cortex are activated following traumatic brain injury. J Neurotrauma 29: 828-842, 2012 Aloisi F: Immune function of microglia. Glia 36:165-179, 2001 Arneth BM: Protective autoimmunity and protein localization. J Neuroimmunol 219: 123-125, 2010
  3. Beauchamp K, Mutlak H, Smith WR, Shohami E, Stahel PF: Pharmacology of traumatic brain injury: Where is the “golden bullet”? Mol Med 14:731-740, 2008
  4. Bernardi S, Severini GM, Zauli G, Secchiero P: Cell-based therapies for diabetic complications. Exp Diabetes Res 2012: 872504, 2012
  5. Biber K, Neumann H, Inoue K, Boddeke HW: Neuronal ‘On’ and ‘Off’ signals control microglia. Trends Neurosci 30:596- 602, 2007
  6. Brait VH, Arumugam TV, Drummond GR, Sobey CG: Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia. J Cereb Blood Flow Metab 32: 598-611, 2012
  7. Brazelton TR, Rossi FM, Keshet GI, Blau HM: From marrow to brain: Expression of neuronal phenotypes in adult mice. Science 290: 1775-1779, 2000
  8. Cai J, Li W, Su H, Qin D, Yang J, Zhu F, Xu J, He W, Guo X, Labuda K, Peterbauer A, Wolbank S, Zhong M, Li Z, Wu W, So KF, Redl H, Zeng L, Esteban MA, Pei D: Generation of human induced pluripotent stem cells from umbilical cord matrix and amniotic membrane mesenchymal cells. J Biol Chem 285: 11227-11234, 2010
  9. Cai M, Shen R, Song L, Lu M, Wang J, Zhao S, Tang Y, Meng X, Li Z, He ZX: Bone marrow mesenchymal stem cells (BMMSCs) improve heart function in swine myocardial infarction model through paracrine effects. Sci Rep 6: 28250, 2016
  10. Chen DY, Wei HJ, Lin KJ, Huang CC, Wang CC, Wu CT, Chao KT, Chen KJ, Chang Y, Sung HW: Three-dimensional cell aggregates composed of HUVECs and cbMSCs for therapeutic neovascularization in a mouse model of hindlimb ischemia. Biomaterials 34:1995-2004, 2013
  11. Chen S, Chen X, Wu X, Wei S, Han W, Lin J, Kang M, Chen L: Hepatocyte growth factor-modified mesenchymal stem cells improve ischemia/reperfusion-induced acute lung injury in rats. Gene Ther 24(1):3-11, 2017
  12. Chopp M, Li Y: Treatment of neural injury with marrow stromal cells. Lance