AI Summary & Key Takeaways
AI InsightWe believe that nutritional support with fish-oil emulsion in patients with SCI will result in patient's better clinical outcome and increase in quality of the patient's life.
📌 3 Key Takeaways
Abstract
AIM: Aim of this study is to assess effects of parenteral nutritional support with fish-oil emulsion on spinal cord recovery in rats with traumatic spinal cord injury. MATERIAL and METHODS: For 5 days after SCI rats were received saline in group C and Omegaven in group O. Locomotor strengths (BBB scale)of animals were rated at Day 0,7,14,21,28, and 35. At Day 35 spinal cord sampling was evaluated immunohistochemically. RESULTS: BBB scores were 0 in early period after SCI was inflicted in both groups. BBB scores were progressively increased after Day 7 in both groups (p<.005). BBB scores were significantly higher in group O when compared with control group after Day7 in all times (p<.005). Neuronal injury (p<.002) and edema was much more in control group when compared with in group O (p<.005). Scores for white mater cavitation, demyelinization and vessel in growth were similar in both groups. VEGF expression in control group was higher (p=.019). CONCLUSION: At the early period of SCI fish-oil emulsion treatment in rats, its anti-inflammatory effects leaded to decrease in edema and had positive effect at the prevention of neuronal injury. We believe that nutritional support with fish-oil emulsion in patients with SCI will result in patient's better clinical outcome and increase in quality of the patient's life.
Özet
AMAÇ: Travmatik omurilik yaralanması olan sıçanlarda omegaven ile beslenme desteğinin iyileşme üzerine etkilerinin araştırılmasıdır. YÖNTEM ve GEREÇ: Omurilik hasarını takiben 5 gün boyunca sıçanlara IP 1mL/kg omegaven veya 0.9NaCl verildi. Lokomotor kuvvet (BBB skoru)0,7,14,21,28 ve 35.günlerde kaydedildi. Otuzbeşinci günde omurilikte histopatolojik inceleme yapıldı. BULGULAR: Kontrol grubunda BBB skorları düşük (p<.005), nöronal hasarlanma (p<.002) ve ödem (p<.005) yüksek bulundu. Beyaz maddede kavitasyon, demiyelinizasyon ve damarlanma skorlarında fark saptanmadı. VEGF kontrol grubunda yüksek bulundu(p=.019). SONUÇ: Erken dönemde omurilik hasarında balık yağı emulsiyonu ile beslenme desteğinin antiinflamatuar etki ile ödemi azalttığı ve nöronal hasar üzerine koruyucu etkisi olduğu görüldü. Omurilik yaralanması olan hastalarda balık yağı emulsiyonu ile beslenme desteği daha iyi klinik sonuçlar ve daha yüksek yaşam kalitesi sağlayabilir.