Journals / Turkish Neurosurgery / 2012 / Cilt: 22 - Sayı: 6

Subaraknoid kanamalı hastaların klinik şiddeti ile kalp tipi yağ asidi bağlayıcı proteinin serum düzeyi arasında ilişki var mıdır?

Is there a relationship between serum heart- type fatty acid binding protein level and clinical severity in patients with subarachnoid hemorrhage?

Pages
695–700
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Grades according to the Hunt and Hess and Fisher grading scales were shown to increase in conjunction with an increase in H-FABP levels.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:AIM: The aim of this study was to determine the serum heart-type fatty acid binding protein (H-FABP) levels and cardiac effects in patients presenting with subarachnoid hemorrhage (SAH) and to investigate whether any correlation exists between the cardiac effects and H-FABP.
📊
Key Findings & Data:Results: Serum H-FABP levels of patients were found to be significantly higher than those of controls (p<0.05).
💡
Conclusion & Impact:Grades according to the Hunt and Hess and Fisher grading scales were shown to increase in conjunction with an increase in H-FABP levels.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

AIM: The aim of this study was to determine the serum heart-type fatty acid binding protein (H-FABP) levels and cardiac effects in patients presenting with subarachnoid hemorrhage (SAH) and to investigate whether any correlation exists between the cardiac effects and H-FABP. MaterIal and Methods: Forty-six patients diagnosed as acute SAH in the emergency department were included in this study. Twenty healthy adults were included in the study to serve as controls. Twelve-lead ECG was performed on all patients on admission. H-FABP levels of patients were determined in serum samples taken on admission. Results: Serum H-FABP levels of patients were found to be significantly higher than those of controls (p<0.05). There was no significant correlation between serum H-FABP levels and ECG changes. There was a moderate positive correlation between H-FABP serum levels and the grade according to the Hunt and Hess classification (r=0.43, p<0.05). There was a weak positive correlation between H-FABP serum levels and the grade according to the Fisher radiological classification (r=0.38, p<0.05). ConclusIon: Serum H-FABP levels are increased in patients with SAH. Grades according to the Hunt and Hess and Fisher grading scales were shown to increase in conjunction with an increase in H-FABP levels.

Özet

AMAÇ: Bu çalışmanın amacı, subaraknoid kanama (SAK) ile başvuran hastalarda serum H-FABP seviyesini ve kardiyak etkileri belirlemek ve kardiyak etkileri ile H-FABP arasında ilişkili olup olmadığını araştırmaktır. YÖNTEM ve GEREÇLER: Acil serviste SAK tanısı alan 46 hasta çalışmaya alındı. Ayrıca kontrol grubunu oluşturmak üzere 20 sağlıklı erişkin çalışmaya dahil edildi. Tüm hastalara başvuru anında 12 derivasyonlu EKG çekildi. Hastalardan başvuru anında alınan kan örneklerinden H-FABP düzeyleri belirlendi. BULGULAR: Hastaların serum H-FABP düzeylerinin kontrol grubuna göre anlamlı derecede yüksek olduğu tespit edildi (p<0.05). Serum H-FABP seviyesi ve EKG değişiklikleri arasında anlamlı bir ilişki yoktu. Serum H-FABP düzeyleri ile Hunt Hess sınıflamasına göre evre artışı arasında orta derecede pozitif korelasyon vardı (r=0.43, p<0.05). Serum H-FABP düzeyleri ile Fisher radyolojik sınıflamasına göre evre artışı arasında zayıf bir pozitif korelasyon vardı (r =0.38, p<0.05). SONUÇ: SAK’lı hastalarda serum H-FABP düzeyleri artmaktadır. Serum H-FABP düzeylerindeki artış ile Hunt-Hess ve Fisher Ölçeği arasında korelasyon vardır.

🔖

Cite This Article

YILMAN, M., ÇOKLUK, C., BAYDIN, A., YARDAN, T., KATI, C., GÜNAY, M., MERİÇ, M. (2012). Subaraknoid kanamalı hastaların klinik şiddeti ile kalp tipi yağ asidi bağlayıcı proteinin serum düzeyi arasında ilişki var mıdır?. Turkish Neurosurgery, Cilt: 22 - Sayı: 6, 695–700. https://ajindex.com/articles/405031

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (1)

  1. Bailey WL, Loeser JD: Intracranial aneurysms. JAMA 216: 1993–1996, 1971 2. Barker FG, Heros RC: Clinical aspects of vasospasm. Neurosurg Clin N Am 1:277–288, 1990 3. Biller J, Godersky JC, Adams H: Management of aneurysmal SAH. Stroke 19:1300–1305, 1988 4. Bozkus H, Sarioglu AC: Subarachnoid hemorrhage in the elderly. Turk J Geriatrics Geriatri 2:167-172, 1999 5. Deruty R, Pelissou-Guyotat I, Mottolese C, Amat D, Bognar L: Level of consciousness and age as prognostic factors in aneurysmal SAH. Acta Neurochir 132:1–8, 1995 6. Feigin VL, Lawes CM, Bennett DA, Anderson CS: Stroke epidemiology: A review of population-based studies of incidence, prevalence, and case fatality in the late 20th century. Lancet Neurol 2:43–53, 2003 7. Fisher CM, Kistler JP, Davis JM: Relation of cerebral vasospasm to subarachnoid hemorrhage visualized by computerized tomographic scanning. Neurosurgery 6:1–9, 1980 8. Garraway WM, Whisnant JP, Furlan AJ, Phillips LH, Kurland LT, O’Fallon WM: The declining incidence of stroke. N Engl J Med 300:449–452, 1979 9. Goddard AJ, Raju PP, Gholkar A: Does the method of treatment of acutely ruptured intracranial aneurysms influence the incidence and duration of cerebral vasospasm and clinical outcome? J Neurol Neurosurg Psychiatry 75:868–872, 2004 10. Greenberg MS: Handbook of Neurosurgery, third ed., Lakeland. Florida: Greenberg Graphics Inc, 1994:711–752 11. Hurtig HI, Reiwich M: Clinical aspect of cerebrovascular disease. In Golde Sohn ES, Apple SH (Eds), Neurology. Philadelphia: Lea & Febiger, 1977:769–811 12. Kassell NF, Drake CG: Review of the management of saccular aneurysms. Neurol Clin 1:73–86, 1983 13. Kassell NF, Torner JC, Haley EC Jr, Jane JA, Adams HP, Kongable GL: The International Cooperative Study on the Timing of Aneurysm Surgery. Part 1: Overall management results. J Neurosurg 73:18–36, 1990 14. Kawasaki T, Azuma A, Sawada T, Sugihara H, Kuribayashi T, Satoh M, Shimizu Y, Nakagawa M: Electrocardiographic score as a predictor of mortality after subarachnoid hemorrhage. Circ J 66:567–570, 2002 15. Koivisto T, Vanninen R, Hurskainen H, Saari T, Hernesniemi J, Vapalathi M: Outcomes of early endovascular versus surgical treatment of ruptured cerebral aneurysms. A prospective randomized study. Stroke 31:2369–2377, 2000 16. Kumral E, Isler M, Terzioglu M: Hemorajik inmelerde elektrokardiografik bulgular: Subaraknoid kanamalarda. Türk Kardioloji Derneği Arş 18:35-38, 1990 17. Lee KC, Huh SK, Park HS, Shin YS, Lee KS: Management o