DBS-induced psychiatric adverse effects may be attributable either to limbic connections and STN-specific oscillations or stimulation of the medial forebrain bundle
📌 3 Key Takeaways
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Objective & Hypothesis:AIm: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for patients with Parkinson's disease (PD) associated with motor complications of long term L-dopa treatment.mAterIAl and methOds: Here we report two cases with DBS- induced manic episode, focusing on the functional and anatomic correlates of psychiatric adverse effects of STN stimulation. results: We present two cases of PD with motor complications due to long term L-dopa treatment that developed their first episodes of mania with psychotic symptoms after bilateral STN-DBS implantation.
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Key Findings & Data:AIm: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for patients with Parkinson's disease (PD) associated with motor complications of long term L-dopa treatment.mAterIAl and methOds: Here we report two cases with DBS- induced manic episode, focusing on the functional and anatomic correlates of psychiatric adverse effects of STN stimulation. results: We present two cases of PD with motor complications due to long term L-dopa treatment that developed their first episodes of mania with psychotic symptoms after bilateral STN-DBS implantation.
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Conclusion & Impact:DBS-induced psychiatric adverse effects may be attributable either to limbic connections and STN-specific oscillations or stimulation of the medial forebrain bundle
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
AIm: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established therapy for patients with Parkinson's disease (PD) associated with motor complications of long term L-dopa treatment.mAterIAl and methOds: Here we report two cases with DBS- induced manic episode, focusing on the functional and anatomic correlates of psychiatric adverse effects of STN stimulation. results: We present two cases of PD with motor complications due to long term L-dopa treatment that developed their first episodes of mania with psychotic symptoms after bilateral STN-DBS implantation. DBS-induced psychiatric adverse effects may be attributable either to limbic connections and STN-specific oscillations or stimulation of the medial forebrain bundle
Özet
AmAÇ: Subtalamik nükleusun (STN) derin beyin stimülasyonu (DBS), uzun süreli L-dopa tedavisinin motor komplikasyonlarının geliştiği Parkinson Hastalığı (PH)'nda uygulanan bir tedavidir.yÖntem ve GereÇler: Bu yazıda, STN stimülasyonunun psikiyatrik yan etkilerinin anatomik ve fonksiyonel bağlantıları üzerinde durularak, DBS sonrasında manik atak gelişen iki olgunun sunulması amaçlandı. BulGulAr: Uzun süreli L-dopa tedavisine bağlı motor komplikasyonları olan ve STN-DBS uygulaması sonrası ilk psikotik belirtili manik atağı ortaya çıkan iki PD olgusunu sunduk. DBS ilişkili psikiyatrik yan etkiler ya limbik bağlantılara ve STN spesifik osilasyonlara ya da medyal ön beyin demetinin uyarılmasına bağlı olabilir
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Cite This Article
TOKER, T. U., ACAR, G., KARADAĞ, R. F., ACAR, F. (2014). Parkinson Hastalığında Subtalamik Nükleusun Derin Beyin Stimülasyonu Sonrası Gelişen Manik Atak: Bir Olgu Sunumu. Turkish Neurosurgery, Cilt: 24 - Sayı: 1, 94–97. https://ajindex.com/articles/404884
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