Added Value of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Predicting Response to Somatostatin Analogs in Acromegaly Patients

Bivariate and multivariate analyses wereused to determine whether the pathological granulation pattern of adenomas (dense versus others) was associated with patients’demographic variables and semi-quantitative MRI parameters.RESULTS: Three parameters formed the logistic model, χ2(3)=23.278, p<0.0001: age (odds ratio [OR]=1.08), hypointensity ofadenomas in T2W images (OR=15.45), and high maximum enhancement ratio in the second interval (ER2max) values (OR=2195.74).The overall accuracy of this model was 85.45% with an area under the curve of 0.880.

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: To investigate the added value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) sequences in predictingsomatostatin analog (SSA) responses in patients with acromegaly.MATERIAL and METHODS: This study included 55 active acromegaly patients with macroadenoma.

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Key Findings & Data:Mean and maximum signalintensities were measured using region of interests in T2-weighted (T2W) and DCE-MRI sequences.

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Conclusion & Impact:Bivariate and multivariate analyses wereused to determine whether the pathological granulation pattern of adenomas (dense versus others) was associated with patients’demographic variables and semi-quantitative MRI parameters.RESULTS: Three parameters formed the logistic model, χ2(3)=23.278, p<0.0001: age (odds ratio [OR]=1.08), hypointensity ofadenomas in T2W images (OR=15.45), and high maximum enhancement ratio in the second interval (ER2max) values (OR=2195.74).The overall accuracy of this model was 85.45% with an area under the curve of 0.880.

🔬Design:Modeling & Simulation

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Özet

AIM: To investigate the added value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) sequences in predictingsomatostatin analog (SSA) responses in patients with acromegaly.MATERIAL and METHODS: This study included 55 active acromegaly patients with macroadenoma. Mean and maximum signalintensities were measured using region of interests in T2-weighted (T2W) and DCE-MRI sequences. Semi-quantitative valuesindicating relative signal intensity ratios and contrast-enhanced kinetics were obtained. Bivariate and multivariate analyses wereused to determine whether the pathological granulation pattern of adenomas (dense versus others) was associated with patients’demographic variables and semi-quantitative MRI parameters.RESULTS: Three parameters formed the logistic model, χ2(3)=23.278, p<0.0001: age (odds ratio [OR]=1.08), hypointensity ofadenomas in T2W images (OR=15.45), and high maximum enhancement ratio in the second interval (ER2max) values (OR=2195.74).The overall accuracy of this model was 85.45% with an area under the curve of 0.880. Sensitivity, specificity, positive predictive, andnegative predictive values of the model were 68.75%, 92.31%, 78.58%, and 87.8%, respectively.CONCLUSION: In patients with newly diagnosed acromegaly, the model created based on the relative T2W signal intensity, patient’sage, and ER2max parameter from DCE-MRI sequences might be used to more accurately predict SSA responses.

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Cite This Article

DURMAZ, E. S., KOÇAK, B., KADIOĞLU, P., ÇOMUNOĞLU, N., ULU, M. O., KOÇER, N., IŞLAK, C., KIZILKILIÇ, O. (2019). Added Value of Dynamic Contrast-Enhanced Magnetic Resonance Imaging in Predicting Response to Somatostatin Analogs in Acromegaly Patients. Turkish Neurosurgery, Cilt: 29 - Sayı: 6, 835–842. https://ajindex.com/articles/404435

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