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Journals / Turkish Neurosurgery / 2020 / Cilt: 30 - Sayı: 6

Investigation of Relationship Between Hypoxic Process and Cancer Stem Cells in Meningioma

İsmail SAYGIN
Emel ÇAKIR
Mustafa Emre ERCİN
Pages
864–870
DOI
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⚡ TL;DR(Too Long; Didn't Read)

In light of these data, new treatment modalities related to CD44 and CD133 stem cell markers and to HIF1α may be developed

📌 3 Key Takeaways

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Objective & Hypothesis:AIM: To investigate the relationship between cancer stem cells (CD133 and CD44) and HIF1α expression in meningioma.
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Key Findings & Data:MATERIAL and METHODS: In an immunohistochemistry experiment, three expert pathologists examined 100 meningioma slides stained for HIF1α, CD133, and CD44 antibodies.
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Conclusion & Impact:In light of these data, new treatment modalities related to CD44 and CD133 stem cell markers and to HIF1α may be developed
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

AIM: To investigate the relationship between cancer stem cells (CD133 and CD44) and HIF1α expression in meningioma. MATERIAL and METHODS: In an immunohistochemistry experiment, three expert pathologists examined 100 meningioma slides stained for HIF1α, CD133, and CD44 antibodies. Statistical analyses were performed using the SPSS 23 Statistics packet program. P values <0.05 were statistically significant. RESULTS: HIF1α staining was correlated with high grade (Grade 2) meningioma. Cytoplasmic staining was negatively correlated with meningioma grade. High grade meningioma was positive for nuclear HIF1α and showed increased cytoplasmic expression of CD44 and CD133.CONCLUSION: In accordance with previous studies, the level of hypoxia and HIF1α were correlated with meningioma grade. Furthermore, expression of HIF1α was correlated with expression of CD133 and CD44, which are cancer stem cell surface markers, as well as with meningioma grade. In light of these data, new treatment modalities related to CD44 and CD133 stem cell markers and to HIF1α may be developed

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Cite This Article

SAYGIN, İ., ÇAKIR, E., ERCİN, M. E. (2020). Investigation of Relationship Between Hypoxic Process and Cancer Stem Cells in Meningioma. Turkish Neurosurgery, Cilt: 30 - Sayı: 6, 864–870. https://ajindex.com/articles/404301

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References (1)

  1. Cantile M, Collina F, D’Aiuto M, Rinaldo M, Pirozzi G, Borsellino C, Franco R, Botti G, Di Bonito M: Nuclear localization of cancer stem cell marker CD133 in triple-negative breast cancer: A case report. Tumori 99(5):e245-250, 2013 2. Chee NT, Lohse I, Brothers SP: mRNA-to-protein translation in hypoxia. Mol Cancer 18(1):49, 2019 3. Depping R, Steinhoff A, Schindler SG, Friedrich B, Fagerlund R, Metzen E, Hartmann E, Köhler M: Nuclear translocation of hypoxia-inducible factors (HIFs): Involvement of the classical importin alpha/beta pathway. Biochim Biophys Acta 1783(3):394-404, 2008 4. El-Saka AM, Zamzam YA: Stem cell markers CD133, MMP-9, and Ki-67 expressions in different grades of meningiomas and their prognostic significance. Egypt J Pathol 33(2):151-156, 2013 5. Fedchenko N, Reifenrath J: Different approaches for interpretation and reporting of immunohistochemistry analysis results in the bone tissue - a review. Diagn Pathol 9:221, 2014 6. Gassoum A, Arbab MA, Aldeaf SAH, Elhassan LA, Bashier BM: CD44 expressıon in Sudanese meningioma patients. Int J Recent Sci Res 7(6):11900-11904, 2016 7. Huang M, Zhu H, Feng J, Ni S, Huang J: High CD133 expression in the nucleus and cytoplasm predicts poor prognosis in nonsmall cell lung cancer. Dis Markers 2015:986095, 2015 8. Lee HJ, Jung YH, Choi GE, Kim JS, Chae CW, Han HJ: Role of HIF1α regulatory factors in stem cells. Int J Stem Cells 12(1):8-20, 2019 9. Lewy-Trenda I, Omulecka A, Janczukowicz J, Papierz W: CD44 Expression in human meningiomas: An immunohistochemical analysis. Pol J Pathol 55(1):33-37, 2004 10. Louis DN, Perry A, Reifenberger G, Deimling AV, Figarella- Branger D, Cavenee WK, et al: The 2016 World Health Organization Classification of Tumors of the central nervous system: A summary. Acta Neuropathol 131(6):803-820, 2016 11. Marta GN, Correa SF, Teixeira MJ: Meningioma: Review of the literature with emphasis on the approach to radiotherapy. Expert Rev Anticancer Ther 11(11):1749-1758, 2011 12. Maynard MA, Ohh M: The role of hypoxia-inducible factors in cancer. Cell Mol Life Sci 64: 2170-2180, 2007 13. McCarty KS, Miller LS, Cox EB, Konrath J, McCarty KS: Estrogen receptor analyses. correlation of biochemical and immunohistochemical methods using monoclonal antireceptor antibodies. Arch Pathol Lab Med 109:716-721, 1985 14. Mojsilovic-Petrovic J, Callaghan D, Cui H, Dean C, Stanimirovic DB, Zhang W: Hypoxia-inducible factor-1 (HIF-1) is involved in the regulation of hypoxia-stimulated expres