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Journals / Turkish Neurosurgery / 2020 / Cilt: 30 - Sayı: 5

The Effect of Indicators of Systemic Inflammatory Response on Survival in Glioblastoma Multiforme

Özlem MERMUT
Berrin İNANÇ
Pages
658–665
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Overall survival (OS) was calculated from surgery to death or the last contact.Progression-free survival (PFS) was calculated from surgery to progression.

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Objective & Hypothesis:AIM: To evaluate the prognostic value of preoperative neutrophil-to-lymphocyte ratio and platelet-lymphocyte ratio in glioblastomamultiforme patients.MATERIAL and METHODS: A total of 75 patients retrospectively analysed.
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Key Findings & Data:In our study, cut-off values for PLR 150 (platelet-lymphocyte ratio) and NLR 4 (neutrophil-to-lymphocyte ratio) werefound to be significant by creating the ROC curve.
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Conclusion & Impact:Overall survival (OS) was calculated from surgery to death or the last contact.Progression-free survival (PFS) was calculated from surgery to progression.
🔬Design:Research Article
📍Scope:2018 Verileri
⚙️Variables:Domain Parameters

Özet

AIM: To evaluate the prognostic value of preoperative neutrophil-to-lymphocyte ratio and platelet-lymphocyte ratio in glioblastomamultiforme patients.MATERIAL and METHODS: A total of 75 patients retrospectively analysed. The complete blood count of the patients was analysedbefore surgery. In our study, cut-off values for PLR 150 (platelet-lymphocyte ratio) and NLR 4 (neutrophil-to-lymphocyte ratio) werefound to be significant by creating the ROC curve. Overall survival (OS) was calculated from surgery to death or the last contact.Progression-free survival (PFS) was calculated from surgery to progression. The last follow-up was November 2018.RESULTS: The median OS was significantly shorter in PLR>150 patients (p=0.005; 10 vs 17 months). And the median OS wassignificantly shorter in NLR>4 patients too (p=0.010; 11 vs 17 months). In multivariate analysis, Karnofsky performance score 4 (HR:2.14, 95% CI:1.11-4.14; p=0.023) were statistically significant for OS were found to be independentprognostic factor.CONCLUSION: The presence of 70 4,70<KPS, type of surgical resection were independent prognostic factors that negatively affect for the OS.

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Cite This Article

MERMUT, Ö., İNANÇ, B. (2020). The Effect of Indicators of Systemic Inflammatory Response on Survival in Glioblastoma Multiforme. Turkish Neurosurgery, Cilt: 30 - Sayı: 5, 658–665. https://ajindex.com/articles/404289

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References (1)

  1. Alexiou GA, Vartholomatos E, Voulgaris S: Prognostic value of neutrophil-to-lymphocyte ratio in patients with glioblastoma. J Neurooncol 115:521-522, 2013 2. Bambury RM, Teo MY, Power DG, Yusuf A, Murray S, Battley JE, Drake C, O’Dea P, Bermingham N, Keohane C, Grossman SA, Moylan EJ, O’Reilly S: The association of pre-treatment neutrophil to lymphocyte ratio with overall survival in patients with glioblastoma multiforme. J Neurooncol 114:149-154, 2013 3. Forrest LM, McMillan DC, McArdle CS, Angerson WJ, Dunlop DJ: Evaluation of cumulative prognostic scores based on the systemic inflammatory response in patients with inoperable non-small cell lung cancer. Br J Cancer 89:1028-1030, 2003 4. Gu X, Gao X, Li X, Qi X, Ma M, Qin S, Yu H, Sun S, Zhou D, Wang W: Prognostic significance of neutrophil-to-lymphocyte ratio in prostate cancer: Evidence from 16,266 patients. Sci Rep 6:22089, 2016 5. Gunaldi M, Goksu S, Erdem D, Gunduz S, Okuturlar Y, Tiken E, Kahraman S, Inan YO, Genc TB, Yıldırım M: Prognostic impact of platelet/lymphocyte and neutro-phil/lymphocyte ratios in patients with gastric cancer: A multicenter study. Int J Clin Exp Med 8:5937-5942, 2015 6. Han S, Liu Y, Li Q, Li Z, Hou H, Wu A: Pre-treatment neutrophilto-lymphocyte ratio is associated with neutrophil and T-cell infiltration and predicts clinical outcome in patients with glioblastoma. BMC Cancer 15:617, 2015 7. Hwang KT, Chung JK, Roh EY, Kim J, Oh S, Kim YA, Rhu J, Kim S: Prognostic influence of preoperative fibrinogen to albumin ratio for breast cancer. J Breast Cancer 20(3):254- 263, 2017 8. Kaya V, Yıldırım M, Yazıcı G, Yalcın AY, Orhan N, Guzel A: Prognostic significance of indicators of systemic inflammatory responses in glioblastoma patients. Asian Pac J Cancer Prev 18(12):3287-3291, 2017 9. Lopes M, Carvalho B, Vaz R, Linhares P: Influence of neutrophil-lymphocyte ratio in prognosis of glioblastoma multiforme. J Neurooncol 136:173-180, 2018 10. Louis DN, Ohgaki H, Wiestler OD, Cavenee WK, Burger PC, Jouvet A, Scheithauer BW, Kleihues P: The 2007 WHO classification of tumours of the central nervous system. Acta Neuropathol 114:97-109, 2007 11. Mason M, Maurice C, McNamara MG, Tieu MT, Lwin Z, Millar BA, Menard C, Laperriere N, Milosevic M, Atenafu EG, Mason W, Chung C: Neutrophil-lymphocyte ratio dynamics during concurrent chemo-radiotherapy for glioblastoma is an independent predictor for overall survival. J Neurooncol 132:463-471, 2017 12. Muller C, Holtschmidt J, Auer M, Heitzer E,