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Journals / Turkish archives of otorhinolaryngology / 2021 / Cilt: 59 - Sayı: 1

Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F

Nevra Keskin YILMAZ
Hasan ALBASAN
Mehmet Kazım BÖRKÜ
Michael PAPARELLA
Sebahattin CÜREOĞLU
Pages
43–48
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Based on our results, we recommend evaluating 3D analyses of RWM, which provide useful data, to better understand the changes in the membrane.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The purpose of this study was to investigate the morphological changes of round window membrane (RWM) in chinchillas with Streptococcus pneumoniae (S. pneumoniae) serotype 7F induced acute otitis media (AOM) by two dimensional (2D) and three dimensional (3D) measurements.
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Key Findings & Data:Methods: Temporal bone specimens taken from 12 chinchillas were divided into two groups.
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Conclusion & Impact:Based on our results, we recommend evaluating 3D analyses of RWM, which provide useful data, to better understand the changes in the membrane.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objective: The purpose of this study was to investigate the morphological changes of round window membrane (RWM) in chinchillas with Streptococcus pneumoniae (S. pneumoniae) serotype 7F induced acute otitis media (AOM) by two dimensional (2D) and three dimensional (3D) measurements. Methods: Temporal bone specimens taken from 12 chinchillas were divided into two groups. The control group consisted of healthy animals that were injected with intrabullar saline. The subjects in the experimental group were induced with AOM by intrabullar injection of S. pneumoniae 7F. The 2D and 3D measurements of RWM were compared between the groups. Results: Dramatic changes were noted in the RWM of the experimental group compared to the control group. The thickness [mean ± standard deviation (SD)] of the RWM was significantly (p<0.05) increased in the experimental group compared to the control group by 2D measurements taken at three different points of RWM. Moreover, 3D measurements revealed that the volume (mean ± SD) of RWM was significantly (p=0.009) increased in the experimental group. Conclusion: The results of our study, which indicated significant change in RWM in both 2D and 3D measurements, may shed light on the relationship between AOM and inner ear diseases. Based on our results, we recommend evaluating 3D analyses of RWM, which provide useful data, to better understand the changes in the membrane.

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Cite This Article

YILMAZ, N. K., ALBASAN, H., BÖRKÜ, M. K., PAPARELLA, M., CÜREOĞLU, S. (2021). Three-Dimensional Analysis of Round Window Membrane in the Chinchilla Model with Acute Otitis Media Induced with Streptococcus Pneumoniae 7F. Turkish archives of otorhinolaryngology, Cilt: 59 - Sayı: 1, 43–48. https://ajindex.com/articles/403357

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References (2)

  1. Schauer LL. Otitis media. Garfunkel LC, Kaczorowski J, Christy C, editors. Pediatric clinical advisor e-book: instant diagnosis and treatment. Elsevier Health Sciences; 2007.p.419-20
  2. Koçyiğit M, Giran Örtekin S, Çakabay T. Otitis media, classification and principles of treatment approach [Article in Turkish] İKSST Derg 2016; 8: 65-70. [Crossref ] 3. Cureoglu S, Schachern PA, Rinaldo A, Tsuprun V, Ferlito A, Paparella MM. Round window membrane and labyrinthine pathological changes: an overview. Acta Otolaryngol 2005; 125: 9-15. [Crossref ] 4. Joglekar S, Morita N, Cureoglu S, Schachern PA, Deroee AF, Tsuprun V, et al. Cochlear pathology in human temporal bones with otitis media. Acta Otolaryngol 2010; 130: 472-6. [Crossref ] 5. Penido ND, Chandrasekhar SS, Borin A, Maranhão AS, Testa JR. Complications of otitis media – a potentially lethal problem still present. Braz J Otorhinolaryngol 2016; 82: 253-62. [Crossref ] 6. Kaya S, Tsuprun V, Hızlı Ö, Schachern PA, Paparella MM, Cureoglu S. Cochlear changes in serous labyrinthitis associated with silent otitis media: a human temporal bone study. Am J Otolaryng 2016; 37: 83-8. [Crossref ] 7. Goycoolea MV, Paparella MM, Goldberg B, Schlievert PM, Carpenter AM. Permeability of the middle ear to staphylococcal pyrogenic exotoxin in otitis media. Int J Pediatr Otorhinolaryngol 1980; 1: 301-8. [Crossref ] 8. Paparella MM, Morizono T, Le CT, Choo YB, Mancini F, Lidén G, et al. Sensorineural hearing loss in otitis media. Ann Otol Rhinol Laryngol 1984; 93: 623-9. [Crossref ] 9. Schachern PA, Paparella MM, Hybertson R, Sano S, Duvall AJ 3rd. Bacterial tympanogenic labyrinthitis, meningitis, and sensorineural damage. Arch Otolaryngol Head Neck Surg 1992; 118: 53-7. [Crossref ] 10. Jiang S, Seale TW, Gan RZ. Morphological changes in the round window membrane associated with Haemophilus influenzaeinduced acute otitis media in the chinchilla. Int J Pediatr Otorhinolaryngol 2016; 88: 74-81. [Crossref ] 11. Sahni RS, Paparella MM, Schachern PA, Goycoolea MV, Le CT. Thickness of the human round window membrane in different forms of otitis media. Arch Otolaryngol Head Neck Surg 1987; 113: 630-4. [Crossref ] 12. Schachern P, Tsuprun V, Cureoglu S, Ferrieri P, Briles D, Paparella M, et al. The round window membrane in otitis media: effect of pneumococcal proteins. Arch Otolaryngol Head Neck Surg 2008; 134: 658-62. [Crossref ] 13. Sun W, Wang W. Advances in research on labyrinth membranous barriers. J Otol 2015; 10: 99-104. [C