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Journals / Türk Dermatoloji Dergisi / 2019 / Cilt: 13 - Sayı: 3

The Efficacy of Interfollicular Epidermal Stem Cells versus Bone Marrow‑Derived Mesenchymal Stem Cells in Cutaneous Wound Healing in Diabetic Rats

Osman Emre KÖSE
Aysel PEKEL
Pages
117–122
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: Clinical results showed that wound size was significantlyreduced in mesenchymal and interfollicular epidermal stem cell-treated groups as compared with controls.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Many sources of stem cells, such as bone marrow stem cells, embriyonic stem cells, adipose-derived stem cells, epidermal stemcells were used extensively for diabetic wound healing.
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Key Findings & Data:Methods: The streptozotocin-inducedSpraque-Dowley rats with 5 mm punch biopsy were used.
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Conclusion & Impact:Results: Clinical results showed that wound size was significantlyreduced in mesenchymal and interfollicular epidermal stem cell-treated groups as compared with controls.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objective: Many sources of stem cells, such as bone marrow stem cells, embriyonic stem cells, adipose-derived stem cells, epidermal stemcells were used extensively for diabetic wound healing. This study investigated whether interfollicular epidermal stem cell versus bonemarrow-derived mesenchymal stem cell effectiveness in the enhancement of diabetic wound healing. Methods: The streptozotocin-inducedSpraque-Dowley rats with 5 mm punch biopsy were used. Rats were divided into three groups: group I diabetic controls receiving no stem cells;group II, rats receiving bone marrow-derived mesenchymal stem cells; group III, rats receiving interfollicular epidermal stem cells. Woundhealing was assessed clinically that regarding healing time and wound size. Results: Clinical results showed that wound size was significantlyreduced in mesenchymal and interfollicular epidermal stem cell-treated groups as compared with controls. Complete wound-healing times were19.4±2.85 days in bone marrow-derived mesenchymal stem cells group versus 20.3±3.45 days in interfollicular epidermal stem cells group and24.7±4.17 in the control group. In the measurement of the wound area, there were no significant differences between the bone marrow-derivedmesenchymal stem cells group (P=0.115) and interfollicular epidermal stem cells group (P=0.085). Conclusions: Interfollicular epidermalstem cells were found as effective as bone marrow-derived mesenchymal cells in the treatment of the diabetic wound.

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Cite This Article

KÖSE, O. E., PEKEL, A. (2019). The Efficacy of Interfollicular Epidermal Stem Cells versus Bone Marrow‑Derived Mesenchymal Stem Cells in Cutaneous Wound Healing in Diabetic Rats. Türk Dermatoloji Dergisi, Cilt: 13 - Sayı: 3, 117–122. https://ajindex.com/articles/402221

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