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Journals / Turkish Journal of Medical Sciences / 2013 / Cilt: 43 - Sayı: 5

Serum leptin levels and their proportional relationship with pro- and antiinflammatory mediators in aggressive periodontitis: preliminary report

Zuhal YETKİN AY
Recep SÜTÇÜ
Havva KOÇAK
Fatma Yeşim KIRZIOĞLU
Pages
825–830
Publication Date
2013-05-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The usage of these kits in analyzing multiple cytokines/mediators might proportionally clarify the pathogenesis of AP.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:To investigate the serum level of leptin (OB) and its relationship with pro- and antiinflammatory cytokines/mediators in aggressive periodontitis (AP) patients.
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Key Findings & Data:Materials and methods: The study population (n = 12) comprised 6 AP patients and 6 periodontally healthy subjects (HC).
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Conclusion & Impact:The usage of these kits in analyzing multiple cytokines/mediators might proportionally clarify the pathogenesis of AP.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Key words: Aggressive periodontitis · leptin · cytokines

Abstract

To investigate the serum level of leptin (OB) and its relationship with pro- and antiinflammatory cytokines/mediators in aggressive periodontitis (AP) patients. Materials and methods: The study population (n = 12) comprised 6 AP patients and 6 periodontally healthy subjects (HC). The fasting venous serum samples were used to determine the OB and the cytokines/mediators belonging to the Th1/Th2/Th17 cells. The correlations among the OB and cytokines/mediators in the serum and clinical periodontal parameters were also investigated. Results: The AP group presented significantly higher serum TGF-b1 and IL-2 concentrations (pg/mL) and lower IL-4, IL-5, IL-12, IL-13, and IL-17A concentrations than the HC group (P < 0.05). The ratios of OB to IL-12, IL-13, and IL-17A were lower and the ratio of OB to TGF-b1 was higher in the AP than in the HC group (P < 0.05). Conclusion: Within the limitation of the small sample size, the results of our study are important in having determined the proportional relationship of OB with the pro- and antiinflammatory cytokines'/mediators' panel in AP patients. The usage of these kits in analyzing multiple cytokines/mediators might proportionally clarify the pathogenesis of AP.

Özet

To investigate the serum level of leptin (OB) and its relationship with pro- and antiinflammatory cytokines/mediators in aggressive periodontitis (AP) patients. Materials and methods: The study population (n = 12) comprised 6 AP patients and 6 periodontally healthy subjects (HC). The fasting venous serum samples were used to determine the OB and the cytokines/mediators belonging to the Th1/Th2/Th17 cells. The correlations among the OB and cytokines/mediators in the serum and clinical periodontal parameters were also investigated. Results: The AP group presented significantly higher serum TGF-b1 and IL-2 concentrations (pg/mL) and lower IL-4, IL-5, IL-12, IL-13, and IL-17A concentrations than the HC group (P < 0.05). The ratios of OB to IL-12, IL-13, and IL-17A were lower and the ratio of OB to TGF-b1 was higher in the AP than in the HC group (P < 0.05). Conclusion: Within the limitation of the small sample size, the results of our study are important in having determined the proportional relationship of OB with the pro- and antiinflammatory cytokines'/mediators' panel in AP patients. The usage of these kits in analyzing multiple cytokines/mediators might proportionally clarify the pathogenesis of AP.

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Cite This Article

AY, Z. Y., SÜTÇÜ, R., KOÇAK, H., KIRZIOĞLU, F. Y. (2013). Serum leptin levels and their proportional relationship with pro- and antiinflammatory mediators in aggressive periodontitis: preliminary report. Turkish Journal of Medical Sciences, Cilt: 43 - Sayı: 5, 825–830. https://ajindex.com/articles/400884

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