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Journals / Turkish Journal of Medical Sciences / 2013 / Cilt: 43 - Sayı: 5

Evaluation of early corneal topographic changes in children with Down syndrome

Murat ASLANKURT
Lokman ASLAN
Adnan AKSOY
Muhammed Mustafa KURT
Murat ÖZDEMİR
Pages
810–814
Publication Date
2013-05-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Corneal abnormalities and subclinical keratoconus are more common in children with Down syndrome.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:To evaluate early corneal changes using a Scheimpflug imaging (SI) system (Pentacam) in a pediatric population with Down syndrome.
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Key Findings & Data:Twenty-seven children with Down syndrome and 30 healthy subjects were enrolled in the study.
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Conclusion & Impact:Conclusion: Corneal abnormalities and subclinical keratoconus are more common in children with Down syndrome.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Key words: Down syndrome · keratoconus · Scheimpflug imaging

Abstract

To evaluate early corneal changes using a Scheimpflug imaging (SI) system (Pentacam) in a pediatric population with Down syndrome. Materials and methods: This study was carried out in a prospective and nonrandomized fashion. Twenty-seven children with Down syndrome and 30 healthy subjects were enrolled in the study. Corneal measurements were done using a Scheimpflug topography system. Central corneal thickness (CCT), minimum corneal thickness (CTmin), central corneal power (CP), difference of central corneal power (DCP) between 2 eyes, inferior superior steepening (I-S), and keratoconus indices were tested with a SI device. Results: Mean CCT and CTmin values were significantly lower in the patient group than in the control group (P < 0.01). Mean CP and DCP values were higher in the patients than in the control group (P < 0.001). Although mean I-S values were not statistically different, 11 eyes in the Down syndrome group and 3 eyes in the control group had 1.20 or higher I-S. Eleven eyes (21.1%) in the patient group and 1 eye (1.7%) in the control group had subclinical keratoconus (P < 0.01), and 20 eyes (38.4%) in the case group and 2 eyes (3.3%) in the control group had at least 1 abnormal parameter (P < 0.01). Conclusion: Corneal abnormalities and subclinical keratoconus are more common in children with Down syndrome.

Özet

To evaluate early corneal changes using a Scheimpflug imaging (SI) system (Pentacam) in a pediatric population with Down syndrome. Materials and methods: This study was carried out in a prospective and nonrandomized fashion. Twenty-seven children with Down syndrome and 30 healthy subjects were enrolled in the study. Corneal measurements were done using a Scheimpflug topography system. Central corneal thickness (CCT), minimum corneal thickness (CTmin), central corneal power (CP), difference of central corneal power (DCP) between 2 eyes, inferior superior steepening (I-S), and keratoconus indices were tested with a SI device. Results: Mean CCT and CTmin values were significantly lower in the patient group than in the control group (P < 0.01). Mean CP and DCP values were higher in the patients than in the control group (P < 0.001). Although mean I-S values were not statistically different, 11 eyes in the Down syndrome group and 3 eyes in the control group had 1.20 or higher I-S. Eleven eyes (21.1%) in the patient group and 1 eye (1.7%) in the control group had subclinical keratoconus (P < 0.01), and 20 eyes (38.4%) in the case group and 2 eyes (3.3%) in the control group had at least 1 abnormal parameter (P < 0.01). Conclusion: Corneal abnormalities and subclinical keratoconus are more common in children with Down syndrome.

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Cite This Article

ASLANKURT, M., ASLAN, L., AKSOY, A., KURT, M. M., ÖZDEMİR, M. (2013). Evaluation of early corneal topographic changes in children with Down syndrome. Turkish Journal of Medical Sciences, Cilt: 43 - Sayı: 5, 810–814. https://ajindex.com/articles/400881

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