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Journals / Turkish Journal of Medical Sciences / 2013 / Cilt: 43 - Sayı: 5

Prognostic factors in patients with glioblastoma multiforme (clinical research)

Mehmet Ali EKİCİ
Turgay BULUT
Bülent TUCER
Seyit Kaan BAŞARSLAN
Ali KURTSOY
Pages
795–804
Publication Date
2013-05-01
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The postoperative KPS of

📌 3 Key Takeaways

🎯
Objective & Hypothesis:To define the independent variables that affect the life spans of patients with glioblastoma multiforme (GBM).
📊
Key Findings & Data:Materials and methods: This study was conducted in the neurosurgery clinic of Erciyes University's Faculty of Medicine, lasting from February 2000 to September 2006.
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Conclusion & Impact:The postoperative KPS of
🔬Design:Research Article
📍Scope:2000 Verileri
⚙️Variables:Key words: Glioblastoma multiforme · prognosis · postoperative tumor volume

Abstract

To define the independent variables that affect the life spans of patients with glioblastoma multiforme (GBM). Materials and methods: This study was conducted in the neurosurgery clinic of Erciyes University's Faculty of Medicine, lasting from February 2000 to September 2006. A total of 98 patients were diagnosed with GBM after tumor resections. Patients' demographic, neurological, radiological, surgical, and clinical features and adjunct therapies were analyzed retrospectively. Results: Of the 98 patients, 36 (36.7%) were female and 62 (65.4%) were male. There were 15 patients (15.3%) still alive. The median survival time (MST) of the gross total resection and subtotal resection groups was 12 and 8 months, respectively. The group with postoperative Karnofsky performance scores (KPS) of =>70 included 56 patients; their survival rate was 19.6% and their MST was 14 months (confidence interval [CI] 95%, 10-18). The postoperative KPS of

Özet

To define the independent variables that affect the life spans of patients with glioblastoma multiforme (GBM). Materials and methods: This study was conducted in the neurosurgery clinic of Erciyes University's Faculty of Medicine, lasting from February 2000 to September 2006. A total of 98 patients were diagnosed with GBM after tumor resections. Patients' demographic, neurological, radiological, surgical, and clinical features and adjunct therapies were analyzed retrospectively. Results: Of the 98 patients, 36 (36.7%) were female and 62 (65.4%) were male. There were 15 patients (15.3%) still alive. The median survival time (MST) of the gross total resection and subtotal resection groups was 12 and 8 months, respectively. The group with postoperative Karnofsky performance scores (KPS) of =>70 included 56 patients; their survival rate was 19.6% and their MST was 14 months (confidence interval [CI] 95%, 10-18). The postoperative KPS of

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Cite This Article

EKİCİ, M. A., BULUT, T., TUCER, B., BAŞARSLAN, S. K., KURTSOY, A. (2013). Prognostic factors in patients with glioblastoma multiforme (clinical research). Turkish Journal of Medical Sciences, Cilt: 43 - Sayı: 5, 795–804. https://ajindex.com/articles/400879

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References (10)

  1. Li SW, Qiu XG, Chen BS, Zhang W, Ren H, Wang ZC et al. Prognostic factors influencing clinical outcomes of glioblastoma multiforme. Chin Med J (Engl) 2009; 122: 1245– Albert FK, Forsting M, Sartor K, Adams HP, Kunze S. Early postoperative magnetic resonance imaging after resection of malignant glioma: objective evaluation of residual tumor and its influence on regrowth and prognosis. Neurosurgery 1994; 34: 45–1.
  2. Lacroix M, Abi-Said D, Fourney DR, Gokaslan ZL, Shi W, DeMonte F et al. A multivariate analysis of 416 patients with glioblastoma multiforme: prognosis, extent of resection, and survival. J Neurosurg 2001; 95: 190–8.
  3. Lamborn KR, Chang SM, Prados MD. Prognostic factors for survival of patients with glioblastoma: recursive partitioning analysis. Neuro-Oncol 2004; 6: 227–35.
  4. Helseth R, Helseth E, Johannesen TB, Langberg CW, Lote K, Rİnning P et al. Overall survival, prognostic factors, and repeated surgery in a consecutive series of 516 patients with glioblastoma multiforme. Acta Neurol Scand 2010; 122: 159– Burger PC, Green SB. Patient age, histological features, and length of survival in patients with glioblastoma multiforme. Cancer 1987; 59: 1617–25.
  5. Chang CH, Horton J, Schoenfeld D, Salazer O, Perez-Tamayo R, Kramer S et al. Comparison of postoperative radiotherapy and combined postoperative radiotherapy chemotherapy in the multidisciplinary management of malignant gliomas. A joint radiation therapy oncology group and eastern cooperative oncology group study. Cancer 1983; 52: 997–1007.
  6. Filippini G, Falcone C, Boiardi A, Broggi G, Bruzzone MG, Caldiroli D et al. Brain Cancer Register of the Fondazione IRCCS (Istituto Ricovero e Cura a Carattere Scientifico) Istituto Neurologico Carlo Besta. Prognostic factors for survival in 676 consecutive patients with newly diagnosed primary glioblastoma. Neuro-Oncol 2008; 10: 79–87.
  7. Stark AM, Stepper W, Mehdorn HM. Outcome evaluation in glioblastoma patients using different ranking scores: KPS, GOS, mRS and MRC. Eur J Cancer Care (Engl) 2010; 19: 39– Kleihues P, Cavenee WK. Pathology and Genetics of Tumors of the Nervous System. Lyon: IARC Press; 2000.
  8. Sawaya R, Hammound M, Schoppa D, Hess KR, Wu SZ, Shi WM et al. Neurosurgical outcomes in a modern series of 400 craniotomies for treatment of parenchymal tumors. Neurosurgery 1998; 42: 1044–56.
  9. Rostomily RC, Spence AM, Duong D, McCormick K, Bland M, Berger MS. Multimodality management adult malignant gliomas. Neurosurgery 1994; 35: 378–88.
  10. Green SB, Byar DP, Walk