Journals / Şişli Etfal Hastanesi Tıp Bülteni / 2016 / Cilt: 50 - Sayı: 1

Papiller tiroid kanserinde karşı paratrakeal lenf bezi metastazı gelişimi ile ilişkili risk faktörleri

The Risk Factors for Contralateral Paratracheal Lymph Node Metastases in Papillary Thyroid Cancer

Pages
45–51
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The lateral lymph node metastases detected pre or peroperatively should be considered for the bilateral central neck dissection.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:The risk factors for contralateral paratracheal lymph node metastases in papillary thyroid cancerObjective: Lymph node metastasis is frequently seen in papillary thyroid cancer.
📊
Key Findings & Data:In the present study, we aimed to evaluate the rate and risk factors for the contralateral paratracheal lymph node metastasis in papillary thyroid cancer and to evaluate the effect of risk factors on the extent of the lymphatic dissection.Materials and Methods: Twenty-seven patients (19 female, 8 male) with a median age of 44 , who underwent total thyroidectomy with central neck dissection with or without therapeutical lateral neck dissection were examined.
💡
Conclusion & Impact:The lateral lymph node metastases detected pre or peroperatively should be considered for the bilateral central neck dissection.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

The risk factors for contralateral paratracheal lymph node metastases in papillary thyroid cancerObjective: Lymph node metastasis is frequently seen in papillary thyroid cancer. In the present study, we aimed to evaluate the rate and risk factors for the contralateral paratracheal lymph node metastasis in papillary thyroid cancer and to evaluate the effect of risk factors on the extent of the lymphatic dissection.Materials and Methods: Twenty-seven patients (19 female, 8 male) with a median age of 44 , who underwent total thyroidectomy with central neck dissection with or without therapeutical lateral neck dissection were examined. The effects of the age, gender, extrathyroidal extension, multifocality, bilaterality, lymphovascular invasion, T stage, prelaryngeal, pretracheal, ipsilateral paratracheal and lateral lymph node metastasis on the contralateral paratracheal metastasis were evaluated. 'Chi-square' and 'Fisher's exact' tests were used for statistical analyses.Results: All patients underwent total thyroidectomy with bilateral central neck dissection. Additionally 12 patients out of 27 underwent therapeutical lateral neck dissection. T stages were classified as T1: 16 (59.3%), T2: 7 (25.9%), T3: 4 (14.8%) respectively. The occurance of contralateral paratracheal metastasis was found significantly higher in the cases having lateral metastasis (100% vs 47.6; p=0.05). Conclusions: Lymph node metastasis is frequently seen in papillary thyroid cancer and primarily occurs in the ipsilateral paratracheal area. The rate of contralateral paratracheal metastasis is higher in the patients with lateral lymph node metastasis. The lateral lymph node metastases detected pre or peroperatively should be considered for the bilateral central neck dissection.

Özet

Amaç: Papiller tiroid kanserinde lenf bezi metastazı sık görülür. Bu çalışmada; papiller tiroid kanserinde karşı paratrakeal lenf bezi metastazı oranı, karşı taraf lenf bezi metastazı için risk faktörleri ve bunların lenfatik diseksiyon alan genişliğine etkilerinin değerlendirilmesi amaçlandı.Gereç ve Yöntemler: Papiller tiroid kanseri tanılı, tiroidektomi ile birlikte santral ve/veya terapötik lateral boyun diseksiyonu uygulanan, ortanca yaş 44 olan 27 (19K, 8E) hastanın verileri incelendi. Karşı taraf paratrakeal metastaz gelişimi üzerine yaş, cinsiyet, ekstratiroidal yayılım, multifokalite, bilateralite, lenfovasküler invazyon, T evresi, prelaringeal metastaz varlığı, pretrakeal lenf bezi metastazı, aynı taraf paratrakeal lenf bezi metastazı, lateral metastaz varlığının etkisi değerlendirildi. İstatistik olarak ''Ki-kare'' ve ''Fisher'in kesin olasılık'' testleri kullanıldı.Bulgular: Bu hastalara total tiroidektomiye ek olarak bilateral santral diseksiyon ve 12'sine ek olarak terapötik lateral boyun diseksiyonu uygulandı. T evresi sırasıyla T1: 16 (%59.3), T2: 7 (%25.9), T3: 4 (%14.8) idi. Karşı paratrakeal metastaz gelişimi lateral metastaz (%100 vs %47.6; p=0.05) varlığında anlamlı olarak yüksek bulundu. Sonuç: Papiller tiroid kanserinde lenf nodu metastazı sık olup, öncelikle aynı taraf paratrakeal bölge lenf bezlerinde metastaz ortaya çıkmaktadır. Lateral metastazlı hastalarda karşı taraf paratrakeal metastaz gelişme riski daha yüksektir. Ameliyat öncesi veya peroperatif olarak lateral ve/veya lenf bezi metastazı saptanması, bilateral santral boyun diseksiyonu yapılmasında dikkate alınmalıdır.

🔖

Cite This Article

BESLER, E., AYGÜN, N., BOZDAĞ, E., ÇİTGEZ, B., YETKİN, S. G., MİHMANLI, M., ULUDAĞ, M. (2016). Papiller tiroid kanserinde karşı paratrakeal lenf bezi metastazı gelişimi ile ilişkili risk faktörleri. Şişli Etfal Hastanesi Tıp Bülteni, Cilt: 50 - Sayı: 1, 45–51. https://ajindex.com/articles/399620

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (5)

  1. Ahn BH, Kim JR, Jeong HC, Lee JS, Chang ES, Kim YH. Predictive factors of central lymph node metastasis in papillary thyroid carcinoma. Ann Surg Treat Res 2015; 88: 63-8. [CrossRef] Lim YS, Lee JC, Lee YS, Lee BJ, Wang SG, Son SM, et al. Lateral cervical lymph node metastases from papillary thyroid carcinoma: predictive factors of nodal metastasis. Surgery 2011; 150: 116-21. [CrossRef] Roh JL, Kim JM, Park CI. Central lymph node metastasis of unilateral papillary thyroid carcinoma: patterns and factors predictive of nodal metastasis, morbidity, and recurrence. Ann Surg Oncol 2011; 18: 2245-50. [CrossRef] Lungren CI, Hal P, Dickman PW, Zedenius J. Clinically significant prognostic factors for differentiated thyroid carcinoma: a population-based, nested case-control study. Cancer 2006; 106: 524-31. [CrossRef] Çitgez B, Uludağ M, Yetkin SG, Karakoç S, Akgün İE, Kabukçuoğlu F ve ark. Multinodüler guatr nedeniyle tiroidektomi uygulanan hastalarda insidental papiller tiroid mikrokarsinom olgularımız ve tedavisi. Şişli Etfal Hastanesi Tıp Bülteni 2011; 45: 8-12.
  2. Wei T, Chen R, Zou X, Liu F, Li Z, Zhu J. Predictive factors of contralateral paratracheal lymph node metastasis in unilateral papillary thyroid carcinoma. Eur J Surg Oncol 2015; 41: 746-50. [CrossRef] Keum HS, Ji YB, Kim JM, Jeong JH, Choi WH, Ahn YH, et al. Optimal surgical extent of lateral and central neck dissection for papillary thyroid carcinoma located in one lobe with clinical lateral lymph node metastasis. World J Surg Oncol 2012; 10: 221. [CrossRef] Koo BS, Choi EC, Park YH, Kim EH, Lim YC. Occult contralateral central lymph node metastases in papillary thyroid carcinoma with unilateral lymph node metastasis in the lateral neck. J Am Coll Surg 2010; 210: 895-900. [CrossRef] Machens A, Holzhausen HJ, Dralle H. Skip metastases in thyroid cancer leaping the central lymph node compartment. Arch Surg 2004; 139: 43-5. [CrossRef] Mao LN, Wang P, Li ZY, Wang Y, Song ZY. Risk factor analysis for central nodal metastasis in papillary thyroid carcinoma. Oncol Lett 2015; 9: 103-7.
  3. Dragon RH, Duh QY. Tiroit kanserleri boyun diseksiyonunun mantığı. İşgör A, Uludağ M (editör). Tiroit. 1. Baskı. İstanbul: Nobel Tıp Kitabevleri 2013. p.557-65.
  4. Chen Q, Zou XH, Wei T, Huang QS, Sun YH, Zhu JQ. Prediction of ipsilateral and contralateral central lymphnode metastasis in unilateral papillary thyroid carcinoma: a retrospective study. Gland Surg 2015; 4: 288-94.
  5. Besler E, Çitgez B, Aygün N, Köksal HM, Celayif MF, Mihm