SavedAdd your journal

Journals / Sakarya Tıp Dergisi / 2021 / Cilt: 11 - Sayı: 4

How do levels of ferritin, fibrinogen and procalcitonin affect the clinical course of COVID-19 in pregnant women?

Ferritin, fibrinojen ve prokalsitonin düzeyleri gebelerde COVID-19 klinik seyrini nasıl etkiler?

Huri GÜVEY
Canan SOYER ÇALIŞKAN
Samettin ÇELİK
Merve YILMAZ
Zehra YILMAZ
Pages
940–946
Publication Date
2021-12-27
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Results: While there was no significant difference between the ferritin (p = 0,241) and procalcitonin (p = 0,579) values of pregnant women according to the SARS-CoV-2 status, the fibrinogen values of pregnant women with positive test were found to be significantly higher (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objective: Coronavirus disease 2019 (COVID 19) is a pandemic affecting pregnant women as well as lots of people.
📊
Key Findings & Data:The aim of our study is to investigate the effects of inflammatory markers on the course of COVID-19 in pregnant women.
💡
Conclusion & Impact:Results: While there was no significant difference between the ferritin (p = 0,241) and procalcitonin (p = 0,579) values of pregnant women according to the SARS-CoV-2 status, the fibrinogen values of pregnant women with positive test were found to be significantly higher (p
🔬Design:Research Article
📍Scope:2019 Verileri
⚙️Variables:COVID-19 · Gebelik · Ferritin

Abstract

Objective: Coronavirus disease 2019 (COVID 19) is a pandemic affecting pregnant women as well as lots of people. The aim of our study is to investigate the effects of inflammatory markers on the course of COVID-19 in pregnant women. Materials and methods: In this cross-sectional descriptive study, which included 125 pregnant women who were positive for Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 40 women who were negative, patients with COVID-19 were grouped as mild, moderate, and severe according to oxygen saturation, lung involvement findings. Fibrinogen, ferritin, and procalcitonin values of the participants were compared. Results: While there was no significant difference between the ferritin (p = 0,241) and procalcitonin (p = 0,579) values of pregnant women according to the SARS-CoV-2 status, the fibrinogen values of pregnant women with positive test were found to be significantly higher (p

Özet

Amaç: Coronavirus Disease 2019 (COVID-19) birçok insanı olduğu kadar gebeleri de etkileyen bir pandemidir. Çalışmamızın amacı inflamatuar belirteçlerin gebelerde COVID-19 seyrine etkisini araştırmaktır. Gereç ve yöntem: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pozitif olan 125 ve negatif olan 40 gebenin dahil edildiği bu kesitsel tipe tanımlayıcı çalışmada, COVID-19 olan hastalar oksijen satürasyonu, akciğer tutulumu bulgularına göre hafif orta ve ağır olarak gruplandırılmıştır. Fibirnojen, ferritin ve prokalsitonin değerleri karşılaştırılmıştır. Bulgular: SARS-CoV-2 durumuna göre gebelerin ferritin (p=0,241) ve prokalsitonin (p=0,579) değerleri arasında da anlamlı fark saptanmazken, testi pozitif gebelerin fibrinojen değerleri anlamlı olarak yüksek bulunmuştur (p

🔖

Cite This Article

GÜVEY, H., ÇALIŞKAN, C. S., ÇELİK, S., YILMAZ, M., YILMAZ, Z. (2021). How do levels of ferritin, fibrinogen and procalcitonin affect the clinical course of COVID-19 in pregnant women?. Sakarya Tıp Dergisi, Cilt: 11 - Sayı: 4, 940–946. https://ajindex.com/articles/398952

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (13)

  1. World Health Organization. Director-General’s remarks at the media briefing on 2019-nCoV on 11 February 2020. https://www.who.int/dg/speeches/detail/who-director-general-s- remarks-at-the-media-briefing-on-2019-ncov-on-11-february-2020. 2020. p. 2020. (Erişim tarihi: 29.04.2021
  2. Ramanathan K, Antognini D, Combes A, Paden M, Zakhary B, Ogino M,, et al. Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China. Lancet 2020;395(10223):497–506
  3. Schwartz D. The Effects of Pregnancy on Women with COVID-19: Maternal and Infant Outcomes. Clin Infect Dis 2020;71(16):2042–2044
  4. Zaigham M, Andersson O. Maternal and perinatal outcomes with COVID-19: A systematic review of 108 pregnancies. Acta Obstet Gynecol Scand 2020;99(7):823–829
  5. Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. Br J Haematol 2009;145(1):24–33
  6. Di Micco P, Russo V, Carannante N, Imparato M, Cardillo G, Lodigiani C. Prognostic Value of Fibrinogen among COVID-19 Patients Admitted to an Emergency Department: An Italian Cohort Study. J Clin Med 2020;9(12):4134
  7. Lippi G, Cervellin G. Procalcitonin for diagnosing and monitoring bacterial infections: for or against ? Clin Chem Lab Med 2018;56(8):1193–1195
  8. Kell DB, Pretorius E. Serum ferritin is an important inflammatory disease marker, as it is mainly a leakage product from damaged cells. Metallomics 2014;6(4):748–773
  9. Ruddell RG, Hoang-Le D, Barwood J, Rutherford P, Piva T, Watters D, et al. Ferritin functions as a proinflammatory cytokine via iron- independent PKC-ζ/NFκB-regulated signalling in rat hepatic stellate cells. Hepatology 2010;49(3):887–900
  10. Dahan S, Segal G, Katz I, Hellou T, Tietel M, Bryk G, et al. Ferritin as a Marker of Severity in COVID-19 Patients: A Fatal Correlation. IMAJ 2020;22(8):494–500
  11. Delahoy M, Whitaker M, O’Halloran A, Chai SJ, Kirley PD, Alden N, et al. Characteristics and maternal and birth outcomes of hospitalized pregnant women with laboratory-confirmed COVID-19 — COVID-NET, 13 States, March 1–August 22, 2020. MMWR 2020;69(38):1347-1354
  12. Clinical spectrum of SARS-CoV-2 infection. https://www.covid19treatmentguidelines.nih.gov/overview/clinical-spectrum/ (Erişim tarihi 29.04.2021)
  13. Bi X, Su Z, Yan H, Du J, Wang J, Chen L, et al. Prediction of severe illness due to COVID-19 based on an analysis of initial Fibrinogen to Albumin Ratio and Platelet count. Platelets [Internet] 2020;3