SavedAdd your journal

Journals / Turkish Journal of Medical Sciences / 2014 / Cilt: 44 - Sayı: 2

Anti TNF-a therapy might be responsible for an increased incidence of varicocele in patients with ankylosing spondylitis

Ömer YILMAZ
Yunus UGAN
Mahmut YENER
Mehmet UMUL
Mustafa KAYAN
Aykut Recep AKTAŞ
Elif Nisa ÜNLÜ
Bünyamin KISACIK
Bumin DEĞİRMENCİ
Meltem ÇETİN
Pages
311–316
Publication Date
2014-05-18
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The present study shows that patients with AS who were taking anti-TNF-a therapy had an increased prevalence of right-sided and bilateral varicocele compared to patients with AS who were not taking any disease-modifying antirheumatic drugs and the healthy control group.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:To evaluate the effects of anti-tumor necrosis factor-alpha (TNF-a) therapy on the frequency of varicocele in patients with ankylosing spondylitis (AS) using color Doppler ultrasound.
📊
Key Findings & Data:Materials and methods: The patients were divided into 2 groups: patients with AS who were on anti-TNF-a treatment and patients with AS who were not regularly taking any antiinflammatory drugs.
💡
Conclusion & Impact:Conclusion: The present study shows that patients with AS who were taking anti-TNF-a therapy had an increased prevalence of right-sided and bilateral varicocele compared to patients with AS who were not taking any disease-modifying antirheumatic drugs and the healthy control group.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Key words: Varicocele · ankylosing spondylitis · color Doppler ultrasound

Abstract

To evaluate the effects of anti-tumor necrosis factor-alpha (TNF-a) therapy on the frequency of varicocele in patients with ankylosing spondylitis (AS) using color Doppler ultrasound. Materials and methods: The patients were divided into 2 groups: patients with AS who were on anti-TNF-a treatment and patients with AS who were not regularly taking any antiinflammatory drugs. Thirty-one healthy volunteers were included as controls. Results: Left-sided varicocele was determined in 14 patients of Group 1 (44%), 10 patients of Group 2 (33%), and 7 of the controls (23%). There was a statistically significant difference only between Group 1 and controls (P = 0.009). However, right-sided varicocele was determined in 12 patients of Group 1 (38%), 2 patients of Group 2 (6%), and 2 of the controls (6%) (P = 0.01 vs. Group 2, P = 0.005 vs. controls). Conclusion: The present study shows that patients with AS who were taking anti-TNF-a therapy had an increased prevalence of right-sided and bilateral varicocele compared to patients with AS who were not taking any disease-modifying antirheumatic drugs and the healthy control group.

Özet

To evaluate the effects of anti-tumor necrosis factor-alpha (TNF-a) therapy on the frequency of varicocele in patients with ankylosing spondylitis (AS) using color Doppler ultrasound. Materials and methods: The patients were divided into 2 groups: patients with AS who were on anti-TNF-a treatment and patients with AS who were not regularly taking any antiinflammatory drugs. Thirty-one healthy volunteers were included as controls. Results: Left-sided varicocele was determined in 14 patients of Group 1 (44%), 10 patients of Group 2 (33%), and 7 of the controls (23%). There was a statistically significant difference only between Group 1 and controls (P = 0.009). However, right-sided varicocele was determined in 12 patients of Group 1 (38%), 2 patients of Group 2 (6%), and 2 of the controls (6%) (P = 0.01 vs. Group 2, P = 0.005 vs. controls). Conclusion: The present study shows that patients with AS who were taking anti-TNF-a therapy had an increased prevalence of right-sided and bilateral varicocele compared to patients with AS who were not taking any disease-modifying antirheumatic drugs and the healthy control group.

🔖

Cite This Article

YILMAZ, Ö., UGAN, Y., YENER, M., UMUL, M., KAYAN, M., AKTAŞ, A. R., ÜNLÜ, E. N., KISACIK, B., DEĞİRMENCİ, B., ÇETİN, M. (2014). Anti TNF-a therapy might be responsible for an increased incidence of varicocele in patients with ankylosing spondylitis. Turkish Journal of Medical Sciences, Cilt: 44 - Sayı: 2, 311–316. https://ajindex.com/articles/394071

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Arnett FC. Ankylosing spondylitis. In: Koopman WJ, editor. Arthritis and Allied Conditions. Philadelphia, PA, USA: Lippincott Williams and Wilkins; 2001. pp. 1311–1323. 2. Khan MA. Ankylosing spondylitis: clinical features. In: Klippel J, Dieppe P, editors. Rheumatology. 2nd ed. London: Mosby- Wolfe; 1998. pp. 6.16.1–6.16.10. Ogul H, Bayraktutan U, Yildirim OS, Suma S, Ozgokce M, Okur A, Kantarci M. Magnetic resonance arthrography of the glenohumeral joint: ultrasonography-guided technique using a posterior approach. EAJM 2012; 44: 73–78.
  2. Mehta AL, Dogra VS. Intratesticular varicocele. J Clin Ultrasound 1998; 26: 49–51.
  3. Turgut AT, Özden E, Koşar P, Koşar U, Çakal B, Karabulut A. Chronic constipation as a causative factor for development of varicocele in men: a prospective ultrasonographic study. J Ultrasound Med 2007; 26: 5–10.
  4. Koo S, Marty FM, Baden LR. Infectious complications associated with immunomodulating biologic agents. Infect Dis Clin North Am 2010; 24: 285–306.
  5. Palladino MA, Bahjat FR, Theodorakis EA, Moldawer LL. Anti-TNF-alpha therapies: the next generation. Nat Rev Drug Discov 2003; 2: 736–746. van Eijk IC, Peters MJ, Serné EH, van der Horst-Bruinsma IE, Dijkmans BA, Smulders YM, Nurmohamed MT. Microvascular function is impaired in ankylosing spondylitis and improves after tumour necrosis factor alpha blockade. Ann Rheum Dis 2009; 68: 362–366.
  6. Pieringer H, Stuby U, Pohanka E, Biesenbach G. Augmentation index in patients with rheumatoid arthritis and ankylosing spondylitis treated with infliximab. Clin Rheumatol 2010; 29: 723–727.
  7. Syngle A, Vohra K, Sharma A, Kaur L. Endothelial dysfunction in ankylosing spondylitis improves after tumor necrosis factor- alpha blockade. Clin Rheumatol 2010; 29: 763–770.
  8. Van der Linden S, Valkenburg HA, Cats A. Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria. Arthritis Rheum 1984; 27: 361–368.
  9. Braun J, Pham T, Sieper J, Davis J, van der Linden S, Dougados M, van der Heijde D; AS Working Group. International ASAS consensus statement for the use of anti-tumour necrosis factor agents in patients with ankylosing spondylitis. Ann Rheum Dis 2003; 62: 817–824.
  10. Aydingoz U, Yildiz AE, Ozdemir ZM, Yildirim SA, Erkus F, Ergen FB. A critical overview of the imaging arm of the ASAS criteria for diagnosing axial spondyloarthritis: what the radiologist should know. Diagn Interv Radiol 2012; 18: 555– 565. Yilmaz O, Yilmaz S, Kisacik B, Aydogdu M, Bozkurt Y, Erdem