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Journals / Turkish Journal of Obstetrics and Gynecology / 2016 / Cilt: 13 - Sayı: 1

Farklı polikistik over sendromunun fenotiplerinin in vitro fertilizasyon özellikleri ve sonuçlarının karşılaştırılması

Characteristics and outcomes of in vitro fertilization in different phenotypes of polycystic ovary syndrome

Selçuk SELÇUK
ENİS ÖZKAYA
Ahmet ESER
Melda KUYUCU
Hüseyin Tayfun KUTLU
Belgin DEVRANOĞLU
Kenan SOFUOĞLU
Vedat Erkan DAYICIOĞLU
Pages
1–6
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

However, the end point is similar in terms of biochemical, clinical, and ongoing pregnancy rates.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to investigate whether polycystic ovary syndrome (PCOS) phenotype without polycystic ovaries (PCO) differs in terms of in vitro fertilization (IVF) outcomes compared with classic phenotypes.Materials and Methods: This retrospective controlled study included 262 patients who underwent IVF treatment with an indication of unexplained or tubal factor infertility (control group), ovulatory patients with PCO morphology (group 1), PCOS phenotype with oligoanovulation and hyperandrogenemia (group 2), PCOS phenotype with PCO morphology and oligoanovulation (group 3).
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Key Findings & Data:Basal follicle-stimulating hormone level (beta coefficient=0.207, p=0.003), group (beta coefficient=-0.305, p<0.001) and age (beta coefficient=0.311, p<0.001) were significantly associated with the total gonadotropin dose.
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Conclusion & Impact:However, the end point is similar in terms of biochemical, clinical, and ongoing pregnancy rates.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to investigate whether polycystic ovary syndrome (PCOS) phenotype without polycystic ovaries (PCO) differs in terms of in vitro fertilization (IVF) outcomes compared with classic phenotypes.Materials and Methods: This retrospective controlled study included 262 patients who underwent IVF treatment with an indication of unexplained or tubal factor infertility (control group), ovulatory patients with PCO morphology (group 1), PCOS phenotype with oligoanovulation and hyperandrogenemia (group 2), PCOS phenotype with PCO morphology and oligoanovulation (group 3). Outcomes and baseline characteristics of IVF-embryo transfer treatments were compared among all groups. Results: PCOS phenotype without PCO morphology had similar IVF stimulation characteristics compared with classic phenotypes; however, a higher total gonadotropin dose was needed to achieve similar results compared with patients with PCO morphology with or without PCOS. Basal follicle-stimulating hormone level (beta coefficient=0.207, p=0.003), group (beta coefficient=-0.305, p<0.001) and age (beta coefficient=0.311, p<0.001) were significantly associated with the total gonadotropin dose. The number of good quality embryo on transfer day was significantly lower in patients with isolated PCO morphology and PCO morphology with oligoanovulation than in those with PCOS phenotype without PCO morphology.Conclusion: PCO morphology provides easier stimulation, whereas hyperandrogenemia provides better results as good quality embryos. However, the end point is similar in terms of biochemical, clinical, and ongoing pregnancy rates.

Özet

Amaç: Bu çalışmada polikistik over sendromunun (PKOS) farklı fenotiplerinin in vitro fertilizasyon (İVF) sonuçlarının karşılaştırılması amaçlandı.Gereç ve Yöntemler: Bu retrospektif çalışmaya IVF tedavisi uygulanmış açıklanamayan veya tubal faktör infertilitesi olan hastalar (kontrol grup), polikistik over (PKO) morfolojisi olan ovulatuar hastalar (grup 1), oligo-anovulasyonu ve hiperandrojenemisi olan PKOS'lu hastalar (grup 2), PKO morfolojisi ve oligo-anovulasyonu olan hastalar (grup 3) olmak üzere toplam 262 hasta dahil edildi. Gruplar uygulanan İVF-embriyo transferi tedavisinin özellikleri ve sonuçları açısından karşılaştırıldı.Bulgular: PKO morfolojisi olmayan PKOS'lu olgular; klasik PKOS fenotipi olan olgularla karşılaştırıldığında benzer over stimulasyon özellikleri göstermektedir ancak PKO morfolojisi olan olgulara göre daha yüksek gonadotropin dozu gerekmektedir. Bazal folikül uyarıcı hormon düzeyi (beta kat sayısı=0,207, p=0,003), grup (beta kat sayısı=-0,305, p<0,001) ve yaş (beta kat sayısı=0,311, p<0,001) toplam gonadotropin dozuyla istatistiksel olarak anlamlı derecede ilişkili bulundu. İzole PKO morfolojisi olan olguların ve oligo-anovulasyonu olup PKO morfolojisi olan olguların transfer günü iyi kalite embriyo sayısı, PKO morfolojisi olmayan PKOS'lu olgulara göre istatistiksel olarak anlamlı düzeyde daha düşük tespit edildi.Sonuç: PKO morfolojisinin varlığının over stimulasyonunu kolaylaştırdığı, hiperandrojeneminin de embriyo kalitesi üzerine olumlu etkilerinin olduğu saptandı. Ancak gruplar arasında; biyokimyasal gebelik, klinik gebelik ve devam eden gebelik oranları açısından fark tespit edilmedi.

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Cite This Article

SELÇUK, S., ÖZKAYA, E., ESER, A., KUYUCU, M., KUTLU, H. T., DEVRANOĞLU, B., SOFUOĞLU, K., DAYICIOĞLU, V. E. (2016). Farklı polikistik over sendromunun fenotiplerinin in vitro fertilizasyon özellikleri ve sonuçlarının karşılaştırılması. Turkish Journal of Obstetrics and Gynecology, Cilt: 13 - Sayı: 1, 1–6. https://ajindex.com/articles/376428

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