Polikistik over sendromu ve D vitamini düzeyleri arasındaki ilişki

Objective & Hypothesis:Objective: The main aim of this study was to determine the association of serum 25-hydroxyvitamin D (25-OH D) levels with hormonal, clinical and metabolic profile in patients with and without Polycystic ovary syndrome (PCOS).Materials and Methods: Forty-eight normal-weight (body mass index (BMI) of 19-24.99 kg/m2) women with PCOS, 36 overweight (BMI of 25-29.9 kg/m2) women with PCOS and 56 normal-weight controls participated in the study.

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Key Findings & Data:Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9:00 am after an overnight fast.

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Conclusion & Impact:J Turk Soc Obstet Gynecol 2015;1:18-24

🔬Design:Research Article

📍Scope:2015 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: The main aim of this study was to determine the association of serum 25-hydroxyvitamin D (25-OH D) levels with hormonal, clinical and metabolic profile in patients with and without Polycystic ovary syndrome (PCOS).Materials and Methods: Forty-eight normal-weight (body mass index (BMI) of 19-24.99 kg/m2) women with PCOS, 36 overweight (BMI of 25-29.9 kg/m2) women with PCOS and 56 normal-weight controls participated in the study. Blood samples were collected in the early follicular phase (between day 2 and day 5 of the menstrual cycle) at 9:00 am after an overnight fast. Circulating concentrations of 25-OH D, luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, TSH, free testosterone, dehydroepiandrosterone sulphate (DHEA-SO4), 17-hydroxyprogesterone, sex hormonebinding globulin (SHBG), fasting insulin, fasting glucose, and lipid profile were assessed.Results: Normal weight (BMI 19-24.99 kg/m2) and overweight (BMI 25-29.99 kg/m2) women with PCOS were compared with normal-weight controls and lower 25-OH D levels were found in both PCOS groups (p<0.05 and p<0.01, respectively 25-OH D significantly negatively correlated with waist circumference (WC), waist-to-hip ratio (WHR), free testosterone and modified Ferriman-Gallwey scores, however, there was a positive correlation between 25-OH D and SHBG levels (p<0.05).Conclusion: Our findings suggest that PCOS is associated with hypovitaminosis D. J Turk Soc Obstet Gynecol 2015;1:18-24

Özet

Amaç: Bu çalışmadaki esas amacımız Polikistik over sendromu (PCOS) olan ve olmayan hastalarda, serum 25 hidroksi vitamin D (25-OH D) düzeyi ile klinik, metabolik ve hormonal parametreler arasındaki ilişkiyi araştırmaktır.Gereç ve Yöntemler: Hastalar: 48 normal kilolu (vücut kitle index (VKİ) 19-24,99 kg/m2), 36 fazla kilolu (VKİ: 25-29,99 kg/m2) yeni tanısı konulmuş PCOS'lu hasta ve 56 sağlıklı kontrol hastası (VKİ: 19-24,99 kg/m²) çalışmaya dahil edildi. Adetin 2. ile 5. günü arasında 10-12 saatlik açlık sonrası sabah 09:00'da kan örnekleri alındı. Serum 25 hidroksi vitamin D (25-OH D), FSH, LH, E2, serbest testesteron (st), prolaktin, TSH, 17-OH progesteron, seks hormon bağlayıcı globulin (SHBG), açlık insulin, açlık glukoz, ve lipid profili değerlendirildi.Bulgular: 25-OH D düzeyi normal ve kilolu PCOS'lu hastalarda da kontrol grubuna göre istatistiksel olarak anlamlı düşük düzeylerde bulundu (p<0,05, p<0,01 sırası ile). 25-OH D düzeyi ile bel çevresi, bel kalça oranı, serbest testesteron, modifiye Ferriman Galwey skoru arasında istatistiksel olarak anlamlı negatif korelasyon; SHBG ile pozitif korelasyon saptandı.Sonuç: PCOS, D vitamini eksikliği ile ilişkilidir. J Turk Soc Obstet Gynecol 2015;1:18-24

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Cite This Article

YILMAZ, S. A., ALTINKAYA, S. Ö., KEBABÇILAR, A., KERİMOĞLU, Ö. S., PEKİN, A. T., ABUŞOĞLU, S., ÇELİK, Ç., ÜNLÜ, A. (2015). Polikistik over sendromu ve D vitamini düzeyleri arasındaki ilişki. Turkish Journal of Obstetrics and Gynecology, Cilt: 12 - Sayı: 1, 18–24. https://ajindex.com/articles/376346

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