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Journals / Turkish Journal of Obstetrics and Gynecology / 2016 / Cilt: 13 - Sayı: 3

ADAMTS genlerinin preeklampside rolü

The role of ADAMTS genes in preeclampsia

İrem Eda GÖKDEMİR
Özlem EVLİYAOĞLU
BUĞRA ÇOŞKUN
Pages
149–153
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The roles of ADAMTS in preeclampsia may include regulation of spiral artery invasion and ECM arrangement of the placenta.

📌 3 Key Takeaways

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Objective & Hypothesis:Preeclampsia is a complex disease that increases both maternal and fetal morbidity and mortality in both developed and developing countries.
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Key Findings & Data:It complicates around 5-10% of all pregnancies..The pathophysiology of preeclampsia includes both maternal and fetal/placental factors.
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Conclusion & Impact:The roles of ADAMTS in preeclampsia may include regulation of spiral artery invasion and ECM arrangement of the placenta.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Preeclampsia is a complex disease that increases both maternal and fetal morbidity and mortality in both developed and developing countries. It complicates around 5-10% of all pregnancies..The pathophysiology of preeclampsia includes both maternal and fetal/placental factors. Implantation of embryo and placentation are crucial steps for development of pregnancy involving trophoblast invasion. Abnormalities of spiral artery invasion, trophoblast function, inflammatory process, and biologic functions of angiogenic/anti-angiogenic factors early in pregnancy result in pregnancy diseases, including preeclampsia. ADAMTS genes are members of the family of matrix metalloproteinase, which have important tasks in extracellular matrix (ECM) degradation and repair processes. The roles of ADAMTS in preeclampsia may include regulation of spiral artery invasion and ECM arrangement of the placenta.

Özet

Preeklampsi, gelişmiş ve gelişmekte olan ülkelerde maternal ve fetal morbidite ve mortaliteyi arttıran kompleks bir hastalıktır. Gebeliklerin %5-10'unu komplike eder. Maternal, fetal ve plasental faktörler preeklampsi patofizyolojisinde rol oynarlar. Trofoblast invazyonu, embriyo implantasyonu ve plasentasyon gebelik gelişimi için kritik aşamalardır. Anormal gelişen spiral arter invazyonu, trofoblast fonksiyonu, enflamatuvar süreç ve erken gebelik döneminde anjiyogenik/anti-anjiyogenik faktörlerin biyolojik fonksiyonları preeklampsi gibi gebelikle ilişkili hastalıkların oluşmasına neden olur. ADAMTS, ekstraselüler matriksin (ECM) degradasyonu ve tamir aşamalarında önemli görev yapan matriks metalloproteinaz ailesinin üyesidir. ADAMTS'lerin preeklampsideki rolü, spiral arterlerin invazyonu ve plasentada ECM'nin regülasyonu olabilir.

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Cite This Article

GÖKDEMİR, İ. E., EVLİYAOĞLU, Ö., ÇOŞKUN, B. (2016). ADAMTS genlerinin preeklampside rolü. Turkish Journal of Obstetrics and Gynecology, Cilt: 13 - Sayı: 3, 149–153. https://ajindex.com/articles/376333

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