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Journals / Turkish Journal of Obstetrics and Gynecology / 2016 / Cilt: 13 - Sayı: 1

Over karsinomlarının ayırıcı tanısında Wilms tümör 1'in immünhistokimyasal panelde kullanılması

Utilization of Wilms' tumor 1 antigen in a panel for differential diagnosis of ovarian carcinomas

Dilek ŞEN ŞAKİRAHMET
AYŞE FİLİZ GÖKMEN KARASU
Melin Özgün GEÇER
Nimet KARADAYI
Elif Ablan YAMUÇ
Pages
37–41
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Primary ovarian adenocarcinomas stained positive with WT 1 in 82.5% of the cases and none of the colorectal adenocarcinomas showed staining with WT 1 (0%).Conclusion: WT 1 can be used in conjuction with CK 7 in the differential diagnosis of ovarian carcinomas.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Ovarian metasteses are often mistaken for primary adenocarcinoma.
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Key Findings & Data:Our study objective was to study the usefulness of Wilms tumor 1 (WT 1) antigen in this context.Materials and Methods: The study was conducted at the pathology clinic of Lütfi Kırdar Training and Research Hospital.
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Conclusion & Impact:Primary ovarian adenocarcinomas stained positive with WT 1 in 82.5% of the cases and none of the colorectal adenocarcinomas showed staining with WT 1 (0%).Conclusion: WT 1 can be used in conjuction with CK 7 in the differential diagnosis of ovarian carcinomas.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Ovarian metasteses are often mistaken for primary adenocarcinoma. Studies conducted in recent years have focused on a search for an immunohistochemical marker to aid the differential diagnosis primary and metastatic ovarian carcinoma. Our study objective was to study the usefulness of Wilms tumor 1 (WT 1) antigen in this context.Materials and Methods: The study was conducted at the pathology clinic of Lütfi Kırdar Training and Research Hospital. Deparaffinated blocks of 40 epithelial ovarian tumors, 40 colon adenocarcinomas, and 35 cases of omentum metastases were studied. Cytokeratin 7 (CK 7), cytokeratin 20 (CK 20), and WT 1 were applied to all specimens.Results: All ovarian adenocarcinomas were stained with CK 7 (100%). Colorectal adenocarcinomas were stained positive with CK 20 in 87.5% of cases. Primary ovarian adenocarcinomas stained positive with WT 1 in 82.5% of the cases and none of the colorectal adenocarcinomas showed staining with WT 1 (0%).Conclusion: WT 1 can be used in conjuction with CK 7 in the differential diagnosis of ovarian carcinomas.

Özet

Amaç: Ovaryen metastazlar primer ovaryen adenokarsinomlar ile karışabilirler. Son yıllarda gerçekleştirilen immünhistokimyasal çalışmalar ayırıcı tanıda fayda sağlayabilecek bir marker bulma konusunda yoğunlaşmıştır.Gereç ve Yöntemler: Çalışma Lütfi Kırdar Eğitim ve Araştırma Hastanesi'nde gerçekleştirildi. Kırk over adenokarsinomu, 40 kolon adenokarsinomu ve 35 omentum metastazı tanısı almış patoloji preparatı incelenerek Wilms tümör 1 (WT 1), sitokeratin 7 (SK 7) ve sitokeratin 20 (SK 20) ile immünhistokimyasal çalışma yapıldı.Bulgular: Tüm pimer over adenokarsinomları (%100) SK 7 ile boyanma gösterdi. Kolorektal adenokarsinomların %87,5'i SK 20 ile boyanma gösterdi. Primer over adenokarsinomlarının %82,5'i WT 1 ile boyanma gösterdi. Kolorektal adenokarsinomların hiçbirinde WT 1 ile boyanma izlenmedi. Sonuç: Adenokarsinomların ayırıcı tanısında WT 1 ile SK 7'nin beraber kullanılması tanıya katkı sağlayabilmektedir.

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Cite This Article

ŞAKİRAHMET, D. Ş., KARASU, A. F. G., GEÇER, M. Ö., KARADAYI, N., YAMUÇ, E. A. (2016). Over karsinomlarının ayırıcı tanısında Wilms tümör 1'in immünhistokimyasal panelde kullanılması. Turkish Journal of Obstetrics and Gynecology, Cilt: 13 - Sayı: 1, 37–41. https://ajindex.com/articles/376318

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