Journals / Turkish Journal of Obstetrics and Gynecology / 2016 / Cilt: 13 - Sayı: 1

Gestasyonel diyabet açısından düşük risk taşıyan gebelerde D vitamini eksikliği ile diyabet gelişimi arasında bağlantı yoktur

Vitamin D deficiency in pregnancy is not associated with diabetes mellitus development in pregnant women at low risk for gestational diabetes

Pages
23–26
DOI
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⚡ TL;DR(Too Long; Didn't Read)

The levels of 25 (OH) vitamin D3 of the study groups were found comparable in both groups (p=0.13).Conclusion: Plasma levels of vitamin D may not be a contributing factor for the development of GDM in women with a low risk for GDM.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: We aimed to investigate the effect of vitamin D deficiency as a risk factor for the development of gestational diabetes mellitus (GDM) among pregnant women without known risk factors.Materials and Methods: The study was conducted on pregnant women who had been under regular follow-up and had low risk for GDM development.
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Key Findings & Data:Serum 25 (OH) vitamin D3 levels, hemoglobin, hematocrit, and mean corpuscular volume (MCV) values were measured.
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Conclusion & Impact:The levels of 25 (OH) vitamin D3 of the study groups were found comparable in both groups (p=0.13).Conclusion: Plasma levels of vitamin D may not be a contributing factor for the development of GDM in women with a low risk for GDM.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: We aimed to investigate the effect of vitamin D deficiency as a risk factor for the development of gestational diabetes mellitus (GDM) among pregnant women without known risk factors.Materials and Methods: The study was conducted on pregnant women who had been under regular follow-up and had low risk for GDM development. The patients were divided into two groups according to the presence of GDM; GDM and no GDM (control) group. Body mass index (BMI), sociodemographic data including level of education and nutritional habits were recorded. Serum 25 (OH) vitamin D3 levels, hemoglobin, hematocrit, and mean corpuscular volume (MCV) values were measured. An oral glucose tolerance test was performed, between 24 and 28 weeks of pregnancy.Results: GDM ratio was calculated as 4.6%. The false positive rate of 50 g oral glucose load screening test was found to be 16.5%. The BMI levels of women diagnosed as having GDM and those with no GDM group at the beginningof the pregnancy period were calculated as 24.3±2.6 and 22.8±1.6 kg/m2 respectively, exhibiting a statistically significant difference between the two groups (p=0.001). Hemoglobin, hematocrit, and MCV values did not show a statistically significant difference between the two groups (p>0.05). The levels of 25 (OH) vitamin D3 of the study groups were found comparable in both groups (p=0.13).Conclusion: Plasma levels of vitamin D may not be a contributing factor for the development of GDM in women with a low risk for GDM.

Özet

Amaç: Gestasyonel diabetes mellitus (GDM) için bilinen risk faktörü bulunmayan gebelerde maternal plazma D vitamini eksikliğinin GDM açısından risk faktörü olup olmadığını araştırmaktır.Gereç ve Yöntemler: GDM açısından düşük riskli olup düzenli poliklinik takiplerine gelen gebeler çalışmaya dahil edildi. GDM tanısı alan ve almayan olarak iki gruba ayrılan hastaların vücut kitle indeksi (VKİ) değerleri, sosyodemografik verileri, beslenme alışkanlıkları kaydedildi. Hemoglobin, hematokrit ve ortalama eritrosit hacim (MCV) değerleri ölçüldü. Yirmi dördüncü ve yirmi sekizinci gebelik haftasında oral glukoz yükleme testi yapıldı ve serum 25 (OH) vitamin D3 seviyeleri karşılaştırıldı.Bulgular: Çalışma grubumuzda GDM sıklığı %4,6 bulundu. 50 gr tarama testinin yalancı pozitiflik oranını %16,5 olarak saptandı. Gebelik başlangıcındaki VKİ değerleri GDM tanısı alan hastalarımızda 24,3±2,6 kg/m2 iken, kontrol grubundaki gebelerde 22,8±1,6 kg/m2 tespit edildi (p=0,001). Hemoglobin, hemotokrit ve MCV değerleri kontrol ve GDM gruplarında anlamlı farklılık göstermemiştir (p>0,05). GDM grubu ve kontrol grubunda hastaların 25 (OH) vitamin D3 sırasıyla 28,5±11,6 ve 25,4±9,3 bulunmuştur (p=0,13).Sonuç: Gebelik fizyolojisi normal insan fizyolojisinden farklı olduğu için ve gebelik hormonlarıyla birlikte gebeliğin fizyolojik gelişimi sürecinde insülin rezistansını etkileyecek çok faktör vardır. Çalışmamızda D vitamini düzeyi ile insulin rezistansı ve GDM gelişimi arasında herhangi bir ilişki bulunamamıştır.

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Cite This Article

BAL, M., ERSOY, G. Ş., DEMİRTAŞ, Ö., KURT, S., TAŞYURT, A. (2016). Gestasyonel diyabet açısından düşük risk taşıyan gebelerde D vitamini eksikliği ile diyabet gelişimi arasında bağlantı yoktur. Turkish Journal of Obstetrics and Gynecology, Cilt: 13 - Sayı: 1, 23–26. https://ajindex.com/articles/376317

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