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Journals / Turkish Journal of Obstetrics and Gynecology / 2021 / Cilt: 18 - Sayı: 2

Polikistik over sendromunda DLK1 ve Nesfatin-1 düzeyleri ve metabolik parametrelerle ilişkisi: Prospektif kontrollü çalışma

DLK1 and Nesfatin-1 levels and the relationship with metabolic parameters in polycystic ovary syndrome: Prospective, controlled study

Melike DEMİR ÇALTEKİN
Ayşen CANİKLİOĞLU
Serenat ERİŞ YALÇIN
Demet AYDOĞAN KIRMIZI
Emre BAŞER
Ethem Serdar YALVAÇ
Pages
124–130
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Bu çalışmaya dayanarak, DLK1 PCOS’daki metabolik bozukluklardan sorumlu olabilir ve gelecekte PCOS için yeni bir belirteç olabilir

📌 3 Key Takeaways

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Objective & Hypothesis:oynayan bir nöropeptiddir.
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Key Findings & Data:Polikistik over sendromunda (PCOS) hem DLK1 hem de Nesfatin-1 düzeylerini değerlendirmeyi ve DLK1 ve Nesfatin-1’in metabolik parametrelerle ilişkisini belirlemeyi amaçladık.
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Conclusion & Impact:Bu çalışmaya dayanarak, DLK1 PCOS’daki metabolik bozukluklardan sorumlu olabilir ve gelecekte PCOS için yeni bir belirteç olabilir
🔬Design:Survey & Empirical Study
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

oynayan bir nöropeptiddir. Polikistik over sendromunda (PCOS) hem DLK1 hem de Nesfatin-1 düzeylerini değerlendirmeyi ve DLK1 ve Nesfatin-1’in metabolik parametrelerle ilişkisini belirlemeyi amaçladık. Gereç ve Yöntemler: Kırk dört PCOS tanısı alan kadın ve kontrol grubu olarak da 40 sağlıklı kadın çalışmaya dahil edildi. Katılımcıların venöz kan örnekleri alınarak hormonal, metabolik parametreler, DLK1 ve Nesfatin-1 kan düzeyleri belirlendi. Antropometrik parametreler de belirlendi. İkili karşılaştırma için parametrik olmayan sayısal veriler için Mann-Whitney U testi, parametrik sayısal veriler için Student t-testi kullanıldı. İki değişkenli korelasyonlar, Spearman’nin korelasyon analizi ile araştırıldı. Parametrelerin tanısal performansı alıcı işletim karakteristiği eğri analizi ile değerlendirildi. Bulgular: Bulgular, DLK1 ve Nesfatin-1 düzeylerinin PCOS grubunda daha düşük olduğunu ve bu değerlerdeki farklılıkların istatistiksel olarak anlamlı olduğunu gösterdi. DLK1 seviyeleri ile vücut kitle indeksi (VKİ), bel kalça oranı (BKO), viseral adipozite indeksi (VAİ), açlık serum insülini (FSI), HOMA-IR ve trigliserit seviyeleri arasında anlamlı negatif korelasyon bulundu. Sonuç: Bulgularımız, DLK1 ve Nesfatin-1 düzeylerinin PCOS’da daha düşük olduğunu gösterdi. Bu çalışmaya dayanarak, DLK1 PCOS’daki metabolik bozukluklardan sorumlu olabilir ve gelecekte PCOS için yeni bir belirteç olabilir

Özet

Objective: Delta-like 1 (DLK1) is known to inhibit adipocyte differentiation and nesfatin-1 is a neuropeptide that plays a role in the regulation of nutrition and metabolism. We aimed to assess both the levels of DLK1 and nesfatin-1 in polycystic ovary syndrome (PCOS) and determine the association of DLK1 and nesfatin-1 with metabolic parameters. Materials and Methods: Forty-four patients with PCOS and 40 healthy women as the control group were included in this study. Venous blood samples of the participants were collected, and hormonal, metabolic parameters, DLK1 and nesfatin-1 blood levels were determined. Anthropometric parameters were also determined. For a double comparison, the Mann-Whitney U test was used for non-parametric numerical data, and Student’s t-test was used for parametric numerical data. Bivariate correlations were investigated using Spearman’s correlation analysis. The diagnostic performance of the parameters was evaluated using receiver operating characteristic curve analysis. Results: The findings showed that DLK1 and nesfatin-1 levels were lower among the PCOS group, and the differences in these values were found to be statistically significant. A significant negative correlation was found between DLK1 levels and body mass index (BMI), waist/hip ratio, visceral adiposity index (VAI), fasting serum insulin (FSI), homeostasis model of assessment-insulin resistance (HOMA-IR) and triglyceride levels. A significant negative correlation was found between nesfatin-1 levels and BMI, VAI, FSI, HOMA-IR and triglyceride. Conclusion: The findings showed that DLK1 and nesfatin-1 levels were lower in PCOS. Based on this study, DLK1 may be culpable for metabolic disorders in PCOS and can be a novel marker for PCOS in the future

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Cite This Article

ÇALTEKİN, M. D., CANİKLİOĞLU, A., YALÇIN, S. E., KIRMIZI, D. A., BAŞER, E., YALVAÇ, E. S. (2021). Polikistik over sendromunda DLK1 ve Nesfatin-1 düzeyleri ve metabolik parametrelerle ilişkisi: Prospektif kontrollü çalışma. Turkish Journal of Obstetrics and Gynecology, Cilt: 18 - Sayı: 2, 124–130. https://ajindex.com/articles/376155

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