AI Summary & Key Takeaways
AI InsightResults: There were no significant differences in TO and TS between AS patients and control subjects (TO-AS: -0.0004±0.008, TO-Control: -0.118±0.006; TS-AS: 12.07±1.26, TS-Control: 10.39±1.26, respectively).Conclusion: Although cardiovascular manifestation (including increased morbidity and mortality) of AS has been shown in various studies, HRT parameters, which determine the risk of sudden death, do not seem to be altered in this disease
📌 3 Key Takeaways
Abstract
Objective: Ankylosing spondylitis (AS) is a chronic systemic disease. The risk of cardiovascular morbidity and mortality is high in patients with AS. Heart rate turbulence (HRT) expresses ventriculophasic sinus arrhythmia and has been considered to reflect cardiac autonomic activity. It has been shown that HRT is an independent and powerful predictor of mortality. The aim of this study was to determine HRT changes in patients with AS in comparison with healthy controls. Materials and Methods: Thirty-seven patients with AS (28 men, 9 women; age: 42±2 years, range: 19-69 years) according to the modified New York criteria and 37 age-and gender-matched healthy control subjects without obvious cardiovascular disease (mean age: 40±2 years, range: 23-68 years) were included in this study. Mean duration of AS was 5±3 years (range: 1-20 years). All participants underwent 24-hour Holter ECG. HRT measurements, turbulence onset (TO) and turbulence slope (TS) were calculated with HRT View Version 0.60-0.1 software program. HRT was calculated in patients and healthy controls with at least one ventricular premature beat (VPB) in their Holter recordings. TO is a measure of the early sinus acceleration and TS is the measure of the rate of sinus deceleration that follows the sinus acceleration after a VPB. Results: There were no significant differences in TO and TS between AS patients and control subjects (TO-AS: -0.0004±0.008, TO-Control: -0.118±0.006; TS-AS: 12.07±1.26, TS-Control: 10.39±1.26, respectively).Conclusion: Although cardiovascular manifestation (including increased morbidity and mortality) of AS has been shown in various studies, HRT parameters, which determine the risk of sudden death, do not seem to be altered in this disease
Özet
Amaç: Kronik sistemik bir hastalık olan ankilozan spondilitte (AS), kardiyovasküler mortalite ve morbidite yüksektir. Ventrikülofazik sinüs aritmisini yansıtan heart rate turbulence (HRT), kardiyak otonomik aktiviteyi göstermektedir. HRT mortaliteyi belirlemede bağımsız ve güçlü bir belirleyicidir. Bu çalışmanın amacı AS'li hastalarda HRT parametrelerinin saptanması ve sağlıklı bireyler ile karşılaştırılmasıdır.Yöntem ve Gereçler: Hasta grubunu, New York kriterlerine gore AS tanısı konan 37 hasta oluşturdu . Kontrol grubunu ise cinsiyet ve yaş yönünden hasta grubuna benzer ve bilinen kardiyovasküler hastalığı olmayan, 37 sağlıklı birey oluşturdu . Hastalar, ortalama 5±3 yıldır AS tanısı ile takip edilmekteydi. Çalışmaya katılan tüm bireylerin 24 saatlik Holter kayıtları alındı. HRT parametreleri turbulence onset (TO), ve turbulence slope (TS), olarak HRT View Version 0.60-0.1 software program ile hesaplandı. HRT, Holter kayıtlarında en az 1 ventriküler erken vurusu olan hastalarda ve sağlıklı bireylerde hesaplandı. TO VPB sonrası erken sinus hızlanmasının, TS ise VPB sonrası sinus hızlanmasını takip eden sinus yavaşlamasının ölçütüdür.Bulgular: Ankilozan spondilitteli hastalar ile sağlıklı bireylerin TO ve TS değerleri benzer olarak bulundu, (TO-AS: -0.0004±0.008, TO-kontrol: -0.118±0.006; TS-AS: 12.07±1.26, TS-kontrol: 10.39±1.26).Sonuç: Birçok çalışmada AS'li hastalarda artmış morbidite ve mortaliteyi içeren kardiyovasküler tutulumlar gösterilmiş olmasına rağmen, ani ölümü belirleyebilen HRT parametreleri AS li hastalarda değişmiyor gibi görünmektedir