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Journals / Turkish Journal of Nuclear Medicine (. Molecular Imaging and Radionuclide Therapy) / 2010 / Cilt: 19 - Sayı: 2

Correlation between bone marrow 18-F FDG uptake and hematological parameters in PET/CT scans of untreated malignancy patients

Tedavi almamış malignite tanılı hastaların PET/BT görüntülemesinde kemik iliği 18-F FDG tutulum ölçümleri ile hematolojik parametreler arasındaki korelasyon

Deniz DİNÇER ALPAN
Süreyya GÖNÜL
Ümit OĞUR
Gani DUMAN
Yasemin DEMİRTAŞ ÖZTÜRK
Eray ALPER
Pages
49–57
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The significancy of UR should be kept in mind while examining the effect of hematological parameters on BM,

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to investigate the correlation between bone marrow (BM) F-18 fluoro-2-deoxyglucose (FDG) uptake in Positron Emission Tomography/Computed Tomography (PET/CT) and hematological parameters.
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Key Findings & Data:Material and Methods: In our clinic, 105 patients who underwent PET/CT imaging and with existing hematological parameters (white blood cell (WBC , red blood cell (RBC), platelet (Plt) counts, hemoglobin concentration (Hgb), hematocrit (Hct)) within 5 days before or after the PET/CT imaging were included in this study.
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Conclusion & Impact:The significancy of UR should be kept in mind while examining the effect of hematological parameters on BM,
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to investigate the correlation between bone marrow (BM) F-18 fluoro-2-deoxyglucose (FDG) uptake in Positron Emission Tomography/Computed Tomography (PET/CT) and hematological parameters. Material and Methods: In our clinic, 105 patients who underwent PET/CT imaging and with existing hematological parameters (white blood cell (WBC , red blood cell (RBC), platelet (Plt) counts, hemoglobin concentration (Hgb), hematocrit (Hct)) within 5 days before or after the PET/CT imaging were included in this study. All patients were diagnosed with malignancy, and did not have surgery, chemotherapy and/or radiotherapy. There wasn&#8217;t any evidence of bone/bone marrow and liver involvement by malignant or benign diseases; blood transfusions and cytokines had not been given before the PET/CT imaging. FDG uptake by bone marrow was measured as a standardized uptake value mean (SUVmean) on lower thoracic and upper lumbar vertebrae and the uptake ratio (UR) of the SUV of bone marrow to the SUV of liver was calculated. The correlation between SUV of BM and UR with various hematological parameters was investigated. Results: The correlation between SUV of BM and hematological parameters were not significant. A significant positive correlation was found between UR and WBC counts, neutrophil counts (p<0,01), and a significant negative correlation was found between UR and Hgb concentration (p<0,05). However, RBC, Plt, other WBC subgroups except for neutrophil counts and Hct was not correlated with UR. Conclusion: While evaluating FDG uptake in BM at PET/CT imaging, the WBC and neutrophil counts and Hgb concentration should be taken into consideration. The significancy of UR should be kept in mind while examining the effect of hematological parameters on BM,

Özet

Amaç: Bu çalışmanın amacı, Pozitron Emisyon Tomografisi/Bilgisayarlı Tomografi (PET/BT) çalışmalarında, kemik iliğinde (Kİ) F-18 işaretli Florodeoksiglukoz’un (FDG) tutulumu ile hematolojik parametreler arasındaki korelasyonu araştırmaktı. Gereç ve Yöntemler: Kliniğimizde PET/BT çalışması yapılan ve PET/BT çekiminden 5 gün öncesi veya 5 gün sonrasına ait lökosit (WBC), eritrosit (RBC), trombosit (Plt) sayıları; hemoglobin (Hgb) konsantrasyonu, hematokrit (Hct) değerlerine ulaşılan 105 hasta çalışmaya dahil edildi. Tüm hastalar malignite tanılıydı ve cerrahi tedavi, kemoterapi (KT) ve/veya radyoterapi (RT) almamıştı. Kemiğe ve/veya Kİ’ne ve karaciğere (KC) ait malign veya benign hastalık bulgusu yoktu; PET/BT görüntülemesinden önce kan transfüzyonu, sitokin tedavisi uygulanmamıştı. Kİ’ne ait FDG tutulumları, alt torakal ve üst lomber vertebralarda “Standard Uptake Value mean” (SUVmean) değerleri olarak ölçüldü ve Kİ SUV değerinin KC SUV değerine oranı; tutulum oranı (TO) olarak hesaplandı. Kİ SUV ve TO değerleri ile çeşitli hematolojik parametreler arasındaki korelasyon değerlendirildi. Bulgular: Kİ SUV değerleri ile hematolojik parametreler arasındaki korelasyon anlamlı değildi. Anlamlı pozitif korelasyon TO ile WBC sayısı ve WBC alt grubu olan nötrofil sayısı arasında (p<0,01) ve anlamlı negatif korelasyon TO ile Hgb değeri arasında (p<0,05) saptanırken, TO ile RBC, Plt ve nötrofil dışındaki diğer WBC alt grup sayıları ve Hct değerleri arasında korelasyon saptanmadı. Sonuç: PET/BT görüntülerinde Kİ’nde FDG tutulumu değerlendirilirken hastaların WBC ve nötrofil sayısı, Hgb değeri mutlaka dikkate alınmalıdır. Hematolojik parametrelerin Kİ üzerine etkisi değerlendirilirken TO değerinin anlamlı olduğu unutulmamalıdır.

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Cite This Article

ALPAN, D. D., GÖNÜL, S., OĞUR, Ü., DUMAN, G., ÖZTÜRK, Y. D., ALPER, E. (2010). Correlation between bone marrow 18-F FDG uptake and hematological parameters in PET/CT scans of untreated malignancy patients. Turkish Journal of Nuclear Medicine (. Molecular Imaging and Radionuclide Therapy), Cilt: 19 - Sayı: 2, 49–57. https://ajindex.com/articles/374984

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