Here we report a case of severe everolimus toxicity in a kidney transplant recipient receiving ombitasvir/paritaprevir/ritonavir and dasabuvir combination treatment.
📌 3 Key Takeaways
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Objective & Hypothesis:The incidence of chronic hepatitis C virus (HCV) infection in kidney transplant recipients is 5%-15%, and HCV is an important risk factor for posttransplant kidney issues.
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Key Findings & Data:Novel interferon-free regimens with direct-acting oral antiviral agents have extremely high response rates in solid organ transplant patients with HCV; however, drug–drug interactions, particularly with immunosuppressive agents, should be considered when deciding the treatment.
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Conclusion & Impact:Here we report a case of severe everolimus toxicity in a kidney transplant recipient receiving ombitasvir/paritaprevir/ritonavir and dasabuvir combination treatment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
The incidence of chronic hepatitis C virus (HCV) infection in kidney transplant recipients is 5%-15%, and HCV is an important risk factor for posttransplant kidney issues. Novel interferon-free regimens with direct-acting oral antiviral agents have extremely high response rates in solid organ transplant patients with HCV; however, drug–drug interactions, particularly with immunosuppressive agents, should be considered when deciding the treatment. Here we report a case of severe everolimus toxicity in a kidney transplant recipient receiving ombitasvir/paritaprevir/ritonavir and dasabuvir combination treatment.
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Cite This Article
AKIN, M., BULDUKOĞLU, O. Ç., ADANIR, H., YALÇINKAYA, T., YILMAZ, V. T., YILDIRIM, B., TUNA, Y., SÜLEYMANLAR, İ., DİNÇER, D. (2020). Everolimus Toxicity in a Kidney Transplant Recipient Treated with Ombitasvir/Paritaprevir/Ritonavir and Dasabuvir for Chronic Hepatitis C. Turkish journal of nephrology (Online), Cilt: 29 - Sayı: 1, 82–83. https://ajindex.com/articles/374891
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