Light reflex is weak or unresponsive.Another characteristic of HAS is the absence of deep tendon reflexes, and unilateral involvement is more common.This case report emphasizes that HAS should be considered in the differential diagnosis of patients presenting to the emergency department with anisocoria, and the dilute pilocarpine test can be used in diagnosis.
📌 3 Key Takeaways
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Objective & Hypothesis:Holmes-Adie syndrome (HAS) is a rare syndrome characterized by tonic pupil and the absence of deep tendon reflexes.
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Key Findings & Data:HAS was first described in 1931 and is usually idiopathic, with incidences reported to be 4-7 per 100,000.Although tonic pupil is usually unilateral, it can also be bilateral.
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Conclusion & Impact:Light reflex is weak or unresponsive.Another characteristic of HAS is the absence of deep tendon reflexes, and unilateral involvement is more common.This case report emphasizes that HAS should be considered in the differential diagnosis of patients presenting to the emergency department with anisocoria, and the dilute pilocarpine test can be used in diagnosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Holmes-Adie syndrome (HAS) is a rare syndrome characterized by tonic pupil and the absence of deep tendon reflexes. HAS was first described in 1931 and is usually idiopathic, with incidences reported to be 4-7 per 100,000.Although tonic pupil is usually unilateral, it can also be bilateral. Enlarged and irregular pupil is usually noticed by the patient. Light reflex is weak or unresponsive.Another characteristic of HAS is the absence of deep tendon reflexes, and unilateral involvement is more common.This case report emphasizes that HAS should be considered in the differential diagnosis of patients presenting to the emergency department with anisocoria, and the dilute pilocarpine test can be used in diagnosis.
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Cite This Article
ÇOLAK, Ş., ERDOĞAN, M. Ö., ŞENEL, A., KIBICI, O., KARABOĞA, T., AFACAN, M. A., AKDEMİR, H. U. (2015). A Rare Case in the Emergency Department:Holmes-Adie Syndrome. Turkish journal of emergency medicine (Online), Cilt: 15 - Sayı: 1, 40–42. https://ajindex.com/articles/373976
Martinelli P. Holmes-Adie syndrome. Lancet 2000;18:356. Guaraldi P, Mathias CJ. Progression of cardiovascular auto- nomic dysfunction in Holmes-Adie syndrome. J Neurol Neu- rosurg Psychiatry 2011;82:1046-9.
Bremner FD, Smith SE. Bilateral tonic pupils: Holmes Adie syndrome or generalised neuropathy? Br J Ophthalmol 2007;91:1620-3.
Bakbak B, Donmez H. Adie's tonic pupil. [Article in Turkish] Turk Norol Derg 2009;15:153-4.
Turk A, Gunay M, Erdol H. The role of pupillometric measure- ments at different light amplitudes in diagnosis of Adie's ton- ic pupil. [Article in Turkish] Genel Tıp Derg 2011;21:4. Wilhelm H, Wilhelm B. Diagnosis of pupillary disorders. In: Schiefer U, Wilhelm H, Hart W. Clinical neuro-ophthalmology 2007;55-69.
Bakbak B, Gedik S. Anisocoria. TJO 2012;42:68-72.
Johnson RH, McLellan DL, Love DR. Orthostatic hypotension and the Holmes-Adie syndrome. A study of two patients with afferent baroreceptor block. J Neurol Neurosurg Psychiatry 1971;34:562-70.
Kimber J, Mitchell D, Mathias CJ. Chronic cough in the Holmes- Adie syndrome: association in five cases with autonomic dys- function. J Neurol Neurosurg Psychiatry 1998;65:583-6.
Sogut O, Erdogan MO, Yigit M, Albayrak L. Anisocoria due to datura inoxia. Emergency Med 2013;3:162.