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Journals / Turkish Journal of Clinics and Laboratory / 2018 / Cilt: 9 - Sayı: 3

Relationship between coronary slow flow and mean platelet volume / lymphocyte ratio

Koroner yavaş akımın ortalama trombosit hacmi/lenfosit oranı ile ilişkisi

Murat GÖK
Alparslan KURTUL
Pages
210–215
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This high ratio may be indicative for clinicians following patients with severe coronary slow flow.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: The aim of this study was to investigate the association of the mean platelet volume to lymphocyte ratio, a novel inflammatory marker that is easily calculated, with coronary slow flow severity.
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Key Findings & Data:Material and Method: In this cross-sectional study, a total of 166 patients referred to our hospital between April 2016 and April 2017 were included. 83 patients were included in the coronary slow flow group, and 83 patients were included in the normal coronary flow group.
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Conclusion & Impact:This high ratio may be indicative for clinicians following patients with severe coronary slow flow.
🔬Design:Research Article
📍Scope:2016 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: The aim of this study was to investigate the association of the mean platelet volume to lymphocyte ratio, a novel inflammatory marker that is easily calculated, with coronary slow flow severity. Material and Method: In this cross-sectional study, a total of 166 patients referred to our hospital between April 2016 and April 2017 were included. 83 patients were included in the coronary slow flow group, and 83 patients were included in the normal coronary flow group. Coronary flow velocities of all patients were measured by the Timi Frame Count (TIMI) method. SPSS 22.0 statistical package program was used for analysis of all data. Results: MPVLR was statistically more significant in coronary slow flow group compared to normal coronary flow group. (p<0.001) In multivariate regression analysis, MVPLR was found to be an independent predictor of coronary slow flow. (p<0.001) In addition, there was a positive correlation between HsCRP, total cholesterol, HDL and coronary slow flow. (p<0.05) Conclusion: Mean platelet volume to lymphocyte ratio, a new and simple indicator of inflammation, was found to be higher in patients with coronary slow flow. This high ratio may be indicative for clinicians following patients with severe coronary slow flow.

Özet

Amaç: Bu çalışmanın amacı, kolayca hesaplanabilen yeni bir inflamatuar belirteç olan ortalama trombosit hacmi/ lenfosit oranının koroner yavaş akım şiddeti ile ilişkisini araştırmaktır.Gereç ve Yöntemler: Kesitsel tipte yapılan bu çalışmada, Nisan 2016 ile Nisan 2017 tarihleri arasında hastanemize başvuran toplam 166 hasta dahil edilmiştir. Koroner yavaş akım grubuna 83 hasta, normal koroner akım grubuna 83 hasta dahil edildi. Tüm hastaların koroner akım hızları Timi Kare Sayımı (TIMI) yöntemi ile hesaplanmıştır. Tüm verilerin analizi için SPSS 22.0 istatistiksel paket programı kullanılmıştır.Bulgular: Ortalama trombosit hacmi/ lenfosit oranı, koroner yavaş akım grubunda normal koroner akım grubuna göre istatistiksel olarak daha anlamlı bulundu. (p <0.001) Çok değişkenli lojistik regresyon analizinde, ortalama trombosit hacmi/ lenfosit oranı koroner yavaş akımın bağımsız öngördürücüsü olduğu bulundu. (p <0.001) Buna ek olarak, HsCRP, total kolesterol, HDL ile koroner yavaş akım arasında pozitif bir korelasyon saptandı. (p <0.05)Sonuç: Yeni ve basit bir inflamasyon göstergesi olan ortalama trombosit hacmi / lenfosit oranı, koroner yavaş akım saptanan hastalarda daha yüksek bulundu. Bu yüksek oran, koroner yavaş akım saptanan hastaları takipte klinisyenler için önemli bir gösterge niteliği taşıyor olabilir.

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Cite This Article

GÖK, M., KURTUL, A. (2018). Relationship between coronary slow flow and mean platelet volume / lymphocyte ratio. Turkish Journal of Clinics and Laboratory, Cilt: 9 - Sayı: 3, 210–215. https://ajindex.com/articles/373006

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References (8)

  1. Tambe AA, Demany MA, Zimmerman HA, Mascarenhas E. Angina pectoris and slow flow velocity of dye in coronary arteries. A new angiographic finding. Am Heart J 1972; 84: 66-67
  2. Goel PK, Gupta SK, Agarwal A, Kapoor A. Slow coronary flow: a distinct angiographic subgroup in syndrome X. Angiology 2001; 52: 507–14
  3. Tatli E, Yildirim T, Aktoz M. Does coronary slow flow phenomenon lead to myocardial ischemia? Int J Cardiol 2009; 131: 101-2
  4. Cesar L, Ramires J, Serrano JC at al. Slow coronary run-off in patients with angina pectoris: clinical significance and thallium-201 scintigraphic study. Braz J Med Biol Res 1996; 29: 605-13 5. Nurkalem Z, Alper AT, Orhan AL at al. Mean platelet volume in patients with slow coronary flow and its relationship with clinical presentation. Turk Kardiyol Dern Ars 2008; 36: 363-67
  5. Mosseri M, Yarom R, Gotsman MS, Hasin Y. Histologic evidence for small-vessel coronary artery disease in patients with angina pectoris and patent large coronary arteries. Circulation 1986; 74: 964–72
  6. Li JJ, Qin XW, Li ZC at al. Increased plasma C-reactive protein and interleukin-6 concentrations in patients with slow coronary flow. Clin Chim Acta 2007; 385: 43–47
  7. Turhan H, Saydam GS, Erbay AR at al. Increased plasma soluble adhesion molecules; ICAM-1, VCAM-1, and E-selectin levels in patients with slow coronary flow. Int J Cardiol 2006; 108: 224–30
  8. Cakmak M, Tanriverdi H, Cakmak N, Evrengul H, Cetemen S, Kuru O. Simvastatin may improve myocardial perfusion abnormality in slow coronary flow. Cardiology 2008; 110: 39–44 10. Gökçe M, Kaplan S, Tekelioğlu Y, Erdoğan T, Küçükosmanoğlu M. Platelet function disorder in patients with coronary slow flow. Clin Cardiol 2005; 28: 145–48 11. Massberg S, Schulz C, Gawaz M. Role of platelets in the pathophysiology of acute coronary syndrome. Semin Vasc Med 2003; 3: 147–62 12. Thompson, CB, Eaton, KA, Princiotta, Rushin CA, Valeri CR. Size dependent platelet subpopulations: relationship of platelet volume to ultrastructure, enzymatic activity, and function. Br J Haematol 1982; 50: 509-19 13. Horne BD, Anderson JL, John JM et al. Which white blood cell subtypes predict increased cardiovascular risk? J. Am Coll Cardiol 2005; 45: 1638-43 14. Núñez J, Miñana G, Bodí V at al. Low lymphocyte count and cardiovascular diseases. Curr Med Chem 2011; 18: 3226-33 15. Gibson CM, Cannon CP, Daley WL et al. TIMI frame count a quantitative method of assessing coronary artery flow. Circulation 1996; 93: 879-88 16. Davì G, Patrono C. Platelet a