AI Summary & Key Takeaways
AI InsightThis effect can be blockedby naloxone completely in morphine, and partially in meperidine.
📌 3 Key Takeaways
Özet
Objective: The goal of this study was to investigate and compare the effects of opioids on proximal and distal colon contractions in normalrats and rats with peritonitis, with and without the presence of naloxone in the environment.Methods: The study was approved by Cumhuriyet University Ethics committee. In this study, 16 Wistar Albino male rats were used. Ratswere divided into two groups. Peritonitis was induced using a cecum ligation and perforation method, 24 h before the tissues of rats in theperitonitis group were collected, and sham surgery was performed 24 h before the tissues of rats in the control group were collected. Twenty-four hours after the surgery, rats’ organs were harvested and hung in organ baths. Concentration-dependent inhibitory effects of morphineand meperidine on spontaneous intestinal movements were observed. Any differences between the groups were tested using the Kruskal–Wallistest, and any differences between the groups were tested using the Tukey test.Results: No significant difference was observed between the proximal and distal colon smooth muscle contraction responses in both groupsafter 80 mM Potassium Chloride (KCl) injection (p>0.005). In the peritonitis group, amplitudes and frequencies of spontaneous contractionsin proximal and distal colon significantly increased (p 0.05). In both groups, adding naloxone to the organ baths before addingopioids completely blocked the morphine’s inhibitory effect on the amplitude and frequency (p<0.05), but it could not completely block theinhibition caused by meperidine.Conclusion: Morphine and meperidine exhibit an inhibitory effect on the intestinal motility in both groups. This effect can be blockedby naloxone completely in morphine, and partially in meperidine.