In conclusion, when an infant with urinary tract infection or malformation has electrolyte abnormalities, pediatricians should consider the diagnosis of transient pseudohypoaldosteronism.
📌 3 Key Takeaways
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Objective & Hypothesis:Three infants aged between 38 days and 43 days all presented with poor weight gain, hyponatremia, hyperkalemia, and were diagnosed as having urinary tract infections, which were accompanied by urinary tract malformations in our cases.
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Key Findings & Data:A few days after admission, hormonal studies revealed normal cortisol and 17-hydroxy progesterone levels and markedly high aldosterone levels, thus the patients were diagnosed as having transient pseudohypoaldosteronism.
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Conclusion & Impact:In conclusion, when an infant with urinary tract infection or malformation has electrolyte abnormalities, pediatricians should consider the diagnosis of transient pseudohypoaldosteronism.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Özet
Three infants aged between 38 days and 43 days all presented with poor weight gain, hyponatremia, hyperkalemia, and were diagnosed as having urinary tract infections, which were accompanied by urinary tract malformations in our cases. Hydration and infection treatments were given. A few days after admission, hormonal studies revealed normal cortisol and 17-hydroxy progesterone levels and markedly high aldosterone levels, thus the patients were diagnosed as having transient pseudohypoaldosteronism. After the proper treatment was given, the transient pseudohypoaldosteronism resolved. In conclusion, when an infant with urinary tract infection or malformation has electrolyte abnormalities, pediatricians should consider the diagnosis of transient pseudohypoaldosteronism.
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Cite This Article
CEYLAN, D., BAYRAMOĞLU, E., POLAT, E., ERDEVE, Ş., ÇETİNKAYA, S., AYCAN, Z. (2021). A rare cause of salt-wasting in early infancy: Transient pseudohypoaldosteronism. Turkish archives of pediatrics (Online), Cilt: 56 - Sayı: 1, 75–77. https://ajindex.com/articles/370010
Nandagopal R, Vaidyanathan P, Kaplowitz P. Transient Pseudohypoaldosteronism due to Urinary Tract Infection in Infancy: A Report of 4 Cases. Int J Pediatr Endocrinol 2009
195728. [Crossref] 2. Delforge X, Kongolo G, Cauliez A, Braun K, Haraux E, Buisson P. Transient pseudohypoaldosteronism: a potentially severe condition affecting infants with urinary tract malformation. J Pediatr Urol 2019
e1. [Crossref] 3. Krishnapp V, Ross JH, Kenagy DN, Raina R. Secondary or transient pseudohypoaldosteronism associated with urinary tract anomaly and urinary infection: A case report. Urol Case Rep 2016
[Crossref] 4. Ağladıoğlu SY, Aycan Z, Kendirci HN, Erkek N, Baş VN. Does pseudohypoaldosteronism mask the diagnosis of congenital adrenal hyperplasia? J Clin Res Pediatr Endocrinol 2011
[Crossref] 5. Thies K-C, Boos K, Müller-Deile K, Ohrdorf W, Beushausen T, Townsend P. Ventricular flutter in a neonate-severe electrolyte imbalance caused by urinary tract infection in the presence of urinary tract malformation. J Emerg Med 2000
[Crossref] 6. Manikam L, Cornes MP, Kalra D. Transient pseudohypoaldosteronism masquerading as congenital adrenal hyperplasia. Ann Clin Biochem 2011
[Crossref] 7. Watanabe T. Reversible secondary pseudohypoaldosteronism. Pediatr Nephrol 2003
[Crossref] 8. Bogdanovic R, Stajic N, Putnik J, Paripovic A. Transient type 1 pseudo-hypoaldosteronism: report on an eight-patient series and literature review. Pediatr Nephrol 2009
[Crossref] 9. Tütüncüler F, Günöz H, Bas F, Bundak R, Saka N, Neyzi O. Transient pseudohypoaldosteronism in an infant with urinary tract anomaly. Pediatr Int 2004
[Crossref] 10. Giapros VI, Tsatsoulis AA, Drougia EA, Kollios KD, Siomou EC, Andronikou SK. Rare causes of acute hyperkalemia in the 1st week of life. Three case reports. Pediatr Nephrol 2004
[Crossref] 11. Abdelhamid WA. Prevalence of urinary tract infection in children attending pediatric outpatient clinic in Menoufia University Hospital. Menoufia Med J 2016
Leung AKC, Wong AHC, Leung AAM, Hon KL. Urinary tract infection in children. Recent Pat Inflamm Allergy Drug Discover 2019
[Crossref] 13. Abraham MB, Larkins N, Choong CS, Shetty VB. Transient pseudohypoaldosteronism in infancy secondary to urinary tract infection. J Paediatr Child Health 2017
[Crossref] 14. Clerck MD, Walle JV, Dhont E, Dehoorne J, Keenswijk. An