Journals / Trakya Üniversitesi Tıp Fakültesi Dergisi / 2009 / Cilt: 26 - Sayı: 1

Evaluation of pancreatic malign tumours with mangafodipir trisodium

Mangafodipir trisodyum ile pankreas malign kitlelerinin değerlendirilmesi

Pages
53–58
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: The differences of C/N ratio using Mn-DPDP as a contrast agent may contribute to the diagnosis of pancreatic malign masses.

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Our study aimed to assess the diagnostic capabilities of mangafodipir trisodium (Mn-DPDP)- enhanced magnetic resonance imaging for the evaluation of pancreatic malign mass.
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Key Findings & Data:Patients and Methods: Magnetic resonance images of 17 patients (7 females, 10 males; mean age 63.2±12 years; range 36 to 80 years) suspected of pancreatic tumor by abdominal ultrasonography and computed tomography findings, were examined in terms of signal to noise (S/N) and contrast to noise (C/N) ratios before and after administration of Mn-DPDP using T1 A SE, Fat Sat T1 A SE and GRE T1 A sequences.
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Conclusion & Impact:Conclusion: The differences of C/N ratio using Mn-DPDP as a contrast agent may contribute to the diagnosis of pancreatic malign masses.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Pankreas neoplazmları · Sinyal gürültü oranı · Mangan

Abstract

Objectives: Our study aimed to assess the diagnostic capabilities of mangafodipir trisodium (Mn-DPDP)- enhanced magnetic resonance imaging for the evaluation of pancreatic malign mass. Patients and Methods: Magnetic resonance images of 17 patients (7 females, 10 males; mean age 63.2±12 years; range 36 to 80 years) suspected of pancreatic tumor by abdominal ultrasonography and computed tomography findings, were examined in terms of signal to noise (S/N) and contrast to noise (C/N) ratios before and after administration of Mn-DPDP using T1 A SE, Fat Sat T1 A SE and GRE T1 A sequences. Results: Before and after administration of Mn-DPDP, the increase in S/N ratios of normal pancreatic parenchyma were found as 22.81%, 32.88% and 20% in T1 A SE, Fat Sat T1 A SE and GRE T1 A sequences, respectively. The increase in C/N ratios obtained from signal intensity values of normal pancreatic tissue and tumor were found as 58.69%, 125.41% and 62.06% in T1 A SE, Fat Sat T1 A SE and GRE T1 A sequences, respectively. Furthermore, in all sequences, before and after contrast medium administration, the increase of C/N ratios were found statistically significant (paired Student's t test, p<0.0001). Conclusion: The differences of C/N ratio using Mn-DPDP as a contrast agent may contribute to the diagnosis of pancreatic malign masses.

Özet

Amaç: Organ spesifik ajan olan mangafodipir trisodyum (Mn-DPDP) kullanılarak yapılan manyetik rezonans görüntülemenin pankreas malign kitlelerinin incelenmesinde tanısal etkinliğini incelemek. Hastalar ve Yöntemler: Abdominal ultrasonografi ve bilgisayarlı tomografi bulguları ile pankreas tümörü düşünülen 17 hastanın (7 kadın, 10 erkek; ort. yaş 63.2±12; dağılım 36-80) manyetik rezonans görüntüleri, T1A SE, yağ baskılı T1A SE ve T1A GRE sekanslarının kullanımı ile sinyal-gürültü (S/N) ve kontrast-gürültü (C/N) oranları açısından Mn-DPDP uygulaması öncesi ve sonrası incelendi. Bulgular: Kontrast öncesi ve sonrası incelemelerde normal pankreasın S/N oranlarında artış T1A SE sekansta ortalama %22.81, yağ baskılı T1A SE sekansında %32.88 ve T1A GRE sekansında %20 olarak bulundu. Normal pankreas dokusu ve tümör kitlesi sinyal intensite değerlerinden hesaplanan C/N oranında ise yüzde artış T1A SE sekansı için ortalama %58.69, yağ baskılı T1A SE sekansta %125.41 ve T1A GRE sekansta %62.06 olarak saptandı. Ayrıca uygulanan sinyal intensite ölçümlerine göre her üç sekansta elde edilen kontrast öncesi ve sonrası C/N oranlarındaki artış istatistiksel olarak anlamlı idi (paired Student t testi p<0.0001). Sonuç: Kontrast madde olarak Mn-DPDP'nin kullanımı ile C/N oranlarındaki değişim pankreasın malign kitlelerinin incelenmesinde tanıya katkı sağlayabilir.

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Cite This Article

ARGIMAK, Y., TEMİZÖZ, O., TOSUN, A., ÇAKIR, B. (2009). Evaluation of pancreatic malign tumours with mangafodipir trisodium. Trakya Üniversitesi Tıp Fakültesi Dergisi, Cilt: 26 - Sayı: 1, 53–58. https://ajindex.com/articles/369904

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