SavedAdd your journal

Journals / The European Research Journal / 2021 / Cilt: 7 - Sayı: 6

The impact of weight loss on thyroid autoimmunity - Weight loss decreases thyroid peroxidase antibody levels: a retrospective cohort study

Hacer Hicran MUTLU
Hasan Hüseyin MUTLU
Pages
635–644
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusions: Weight loss caused a decrease in the levels of TPO antibody levels in the obese individuals having thyroid autoimmunity pointing that weight loss might be useful to stop the progression or lead to regression of the disease.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: Within the last two decades, an increase has been seen both in autoimmune diseases and obesity, therefore, the correlation between obesity and autoimmunity has been questioned and many studies have been conducted on this issue.
📊
Key Findings & Data:Methods: The patients who were aged over 18 years, had a Body Mass Index (BMI) ≥ 30 Kg/m2 and TPO antibody ≥ 5.60 IU/mL were included in the study.
💡
Conclusion & Impact:Conclusions: Weight loss caused a decrease in the levels of TPO antibody levels in the obese individuals having thyroid autoimmunity pointing that weight loss might be useful to stop the progression or lead to regression of the disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:autoimmunity · autoantibodies · obesity

Abstract

Objectives: Within the last two decades, an increase has been seen both in autoimmune diseases and obesity, therefore, the correlation between obesity and autoimmunity has been questioned and many studies have been conducted on this issue. Based on this relationship, we aimed to determine whether the weight loss affects the thyroid peroxidase (TPO) antibody levels of obese individuals with thyroid autoimmunity or not. Methods: The patients who were aged over 18 years, had a Body Mass Index (BMI) ≥ 30 Kg/m2 and TPO antibody ≥ 5.60 IU/mL were included in the study. The primary endpoint was the change in TPO antibody levels of the patients at the end of the sixth month of the follow-up. The correlations of TPO antibody levels with anthropometric and laboratory measurements were evaluated. Results: At the end of the sixth month of follow-up of the patients, TPO antibody levels decreased after weight loss (p < 0.001). No significant correlations were found between the differences in weight, fat mass, muscle mass and TPO antibody levels (p = 0.171; p = 0.656; p = 0.939). Conclusions: Weight loss caused a decrease in the levels of TPO antibody levels in the obese individuals having thyroid autoimmunity pointing that weight loss might be useful to stop the progression or lead to regression of the disease.

🔖

Cite This Article

MUTLU, H. H., MUTLU, H. H. (2021). The impact of weight loss on thyroid autoimmunity - Weight loss decreases thyroid peroxidase antibody levels: a retrospective cohort study. The European Research Journal, Cilt: 7 - Sayı: 6, 635–644. https://ajindex.com/articles/368611

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Sims EAH. Characterization of the syndromes of obesity. Diabetes Mellit Obes 1982;219-26
  2. Duntas LH. Environmental factors and thyroid autoimmunity. In: Annales d’endocrinologie. Elsevier; 2011: p. 108-13
  3. Melmed S, Polonsky KS, Larsen PR, Kronenberg HM. Williams Textbook of Endocrinology E-Book. Elsevier Health Sciences; 2015. 4215848 4. Zhao M, Zhang X, Gao L, Song Y, Xu C, Yu C, et al. Palmitic acid downregulates thyroglobulin (Tg), sodium iodide symporter (NIS), and thyroperoxidase (TPO) in human primary thyrocytes: a potential mechanism by which lipotoxicity affects thyroid? Int J Endocrinol 2018;2018:421848
  4. Silva LM, Chavez J, Canalli MHB, Zanetti CR. Determination of IgG subclasses and avidity of antithyroid peroxidase antibodies in patients with subclinical hypothyroidism–a comparison with patients with overt hypothyroidism. Horm Res Paediatr 2003;59:118-24
  5. Rho MH, Kim DW, Hong HP, Park YM, Kwon MJ, Jung SJ, et al. Diagnostic value of antithyroid peroxidase antibody for incidental autoimmune thyroiditis based on histopathologic results. Endocrine 2012;42:647-52
  6. Duntas LH, Biondi B. The interconnections between obesity, thyroid function, and autoimmunity: the multifold role of leptin. Thyroid 2013;23:646-53
  7. Versini M, Jeandel P-Y, Rosenthal E, Shoenfeld Y. Obesity in autoimmune diseases: not a passive bystander. Autoimmun Rev 2014;13:981-1000
  8. Pedersen JK, Svendsen AJ, Hørslev-Petersen K. Incidence of rheumatoid arthritis in the southern part of Denmark from 1995 to 2001. Open Rheumatol J 2007;1:18
  9. Crowson CS, Matteson EL, Davis III JM, Gabriel SE. Contribution of obesity to the rise in incidence of rheumatoid arthritis. Arthritis Care Res (Hoboken) 2013;65:71-7
  10. Karimi F, Omrani GR. Effects of selenium and vitamin C on the serum level of antithyroid peroxidase antibody in patients with autoimmune thyroiditis. J Endocrinol Invest 2019;42:481-7
  11. Cao H. Adipocytokines in obesity and metabolic disease. J Endocrinol 2014;220:T47-59
  12. Procaccini C, Pucino V, Mantzoros CS, Matarese G. Leptin in autoimmune diseases. Metabolism 2015;64:92-104
  13. Harpsøe MC, Basit S, Andersson M, Nielsen NM, Frisch M, Wohlfahrt J, et al. Body mass index and risk of autoimmune diseases: a study within the Danish National Birth Cohort. Int J Epidemiol 2014;43:843-55
  14. Czarnocka B, Janota-Bzowski M, McIntosh RS, Asghar MS, Watson PF, Kemp EH, et al. Immunoglobulin Gκ antithyroid peroxidase antibodies in Hashimoto’s thyroiditis: e