Journals / Turkish Journal of Cancer / 2001 / Cilt: 31 - Sayı: 1

Cytogenetic and CGH studies in a case of pulmonary hamartoma

Pages
15–20
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Comparative genomic hybridization (CGH) showed both gains and losses on different chromosomes in detail in whole genome, and also confirmed former Cytogenetic findings in this patient.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Hamartomas are the most frequent benign tumour of lung that occur in adults and occasionally in children.
📊
Key Findings & Data:A clonal chromosomal aberration add (6) (p21) was observed.
💡
Conclusion & Impact:Comparative genomic hybridization (CGH) showed both gains and losses on different chromosomes in detail in whole genome, and also confirmed former Cytogenetic findings in this patient.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Kromozom sapmaları · Sitogenetik · Hamartom

Abstract

Hamartomas are the most frequent benign tumour of lung that occur in adults and occasionally in children. They produce no symptoms but are often discovered incidentally on chest X-rays. in this report we describe a case of hamartoma. Cytogenetic studies were performed on short term tissue culture from the histopathologically confirmed hamartoma mass. A clonal chromosomal aberration add (6) (p21) was observed. Comparative genomic hybridization (CGH) showed both gains and losses on different chromosomes in detail in whole genome, and also confirmed former Cytogenetic findings in this patient.

Özet

Cytogenetic and CGH studies in a case of pulmonary hamartoma

🔖

Cite This Article

KARAÜZÜM, B. S., KESER, İ., LÜLECİ, G., PAKSOY, N., DEMİRCAN, A. (2001). Cytogenetic and CGH studies in a case of pulmonary hamartoma. Turkish Journal of Cancer, Cilt: 31 - Sayı: 1, 15–20. https://ajindex.com/articles/368505

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (14)

  1. Joseph F, Tomashefski Jr. Benign endobronchial mesenchymal tumors. Am J Surg Pathol 1982;531-40
  2. Gjevre JA, Myers Jl, Prakash UB. Pulmonary hamartomas. Mayo Clin Proc 1996;71:14-20
  3. Lui YS, Thomas RJS, Philips WA. Single-step direct PCR amplification from solid tissues. Nucleic Acids Res 1995;23:1640
  4. Telenius H, Carter NP, Beb CE, et al. Degenerate oligonucleotide-primed PCR: general amplification of target DNA by single degenerate primer. Genomics 1992;13:718-25
  5. James L, Varley J. Preparation, labeling and detection of DNA from archival tissue sections suitable for comparative genomic hybridization. Chromosome Res 1996;4:163-4
  6. Kallioniemi OP, Kallioniemi A, Piper J, et al. Optimizing comparative genomic hybridization for analysis of DNA sequence copy number changes in solid tumors. Genes Chromosom Cancer 1994;10:231-43. 7. du Manoir S, Schröck E, Bentz M, et al. Quantitative analysis of comparative genomic hybridization. Cytometry 1995;19:27-41
  7. Heim S, Mitelman F. Cancer Cytogenetics. In: Chromosomal and Molecular Genetic Aberrations of Tumor Cells. 2nd rev. ed. Wiley-Liss Inc, 1995;314-5
  8. Fletcher JA, Pinkus GS, Weidner N, et al. Lineage-restricted clonality in biphasic solid tumors. Am J Pathol 1991;138:1199-207
  9. Johansson M, Heim S, Mandahl N, et al. t(3;6;14)(p21;p21;q24) as the sole clonal chromosome abnormality in a hamartoma of the lung. Cancer Genet Cytogenet 1992;60:219-20
  10. Johansson M, Dietrich C, Mandahl N, et al. Recombinations of chromosomal bands 6p21 and 14q24 characterise pulmonary hamartomas. Br J Cancer 1993; 67:1236-41
  11. Fletcher JA, Longtine J, Wallace K, et al. Cytogenetic and histologic findings in pulmonary chondroid hamartomas: evidence for a pathogenetic relationship with lipomas and leiomymas. Genes Chromosomes Cancer 1995;12:220-3
  12. Minoletti F, Sozzi G, Calderone C, et al. Variant translocation t(6;10)(p21;q22) in pulmonary chondroid hamartoma. Genes Chromosomes Cancer 1996;15:246-8
  13. Kazmierczak B, Rosigkeit J, Wanschura S, et al. HMGI-C rearrangements as the molecular basis for majority of pulmonary chondroid hamartomas: a survey of 30 tumors. Oncogene 1996;12:515-21
  14. Xiao S, Lux ML, Reeves R, et al. HMGI(Y) activation by chromosome 6p21 rearrangements in multilineage mesenchymal cells from pulmonary hamartoma. Am J Pathol 1997;150:901-10.