As a result, this difference may explain why tumour occurs about 1.5 times more commonly in males than in females.
📌 3 Key Takeaways
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Objective & Hypothesis:We used comparative genomic hybridization (CGH) technique to identify the genetic changes in 8 primary skeletal Ewing's sarcoma samples from archieved paraffin-embedded tissues from children (4-17 years old) using double step degenerate oligonucleotide-primed polymerase chain reaction (DOP-PCR).
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Key Findings & Data:CGH analysis showed t h at the most common genetic alterations were losses of Chromosomes 1p, 2q, 3p, 14q, 21, X and gains of Chromosomes 8q and 17q.
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Conclusion & Impact:As a result, this difference may explain why tumour occurs about 1.5 times more commonly in males than in females.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Çocuk · Sarkom · Ewing
Abstract
We used comparative genomic hybridization (CGH) technique to identify the genetic changes in 8 primary skeletal Ewing's sarcoma samples from archieved paraffin-embedded tissues from children (4-17 years old) using double step degenerate oligonucleotide-primed polymerase chain reaction (DOP-PCR). CGH analysis showed t h at the most common genetic alterations were losses of Chromosomes 1p, 2q, 3p, 14q, 21, X and gains of Chromosomes 8q and 17q. Chromosomal deletions were found only in samples taken from males, while amplifications were identified in both sexes. As a result, this difference may explain why tumour occurs about 1.5 times more commonly in males than in females.
Özet
Comparative genomic hybridization of primary skeletal Ewing's sarcoma
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