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Journals / Turkish Journal of Cancer / 2002 / Cilt: 32 - Sayı: 2

Results of conventionally fractionated radiotherapy in supratentorial malignant glioma patients

Murat GÜRKAYNAK
Mine GENÇ
A. Faruk ZORLU
H. Fadıl AKYOL
İ. Lale ATAHAN
Pages
41–47
DOI
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⚡ TL;DR(Too Long; Didn't Read)

These results were compared with literature.

📌 3 Key Takeaways

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Objective & Hypothesis:Sixty patients with the diagnosis of supratentorial malignant glial tumor, treated between November 1993-June 1997, were retrospectively analyzed.
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Key Findings & Data:The patients had a median age of 47 years and a median Karnofsky Performance Status score of 90.
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Conclusion & Impact:These results were compared with literature.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Gliom · Geriyedönük çalışma · Supratentoryal neoplazmlar

Abstract

Sixty patients with the diagnosis of supratentorial malignant glial tumor, treated between November 1993-June 1997, were retrospectively analyzed. The patients had a median age of 47 years and a median Karnofsky Performance Status score of 90. Histology consisted of anaplastic astrocytoma in 21 (%35) and glioblastoma multiforme in 39 (65%) patients. Median survival was 13 months for all patients, 12 months for GBM patients and 43 months for AA patients. Survival rates at 1 and 3 years were 55%, 28% for all patients; 39%, 12% for GBM patients and 80%, 54% for AA patients, respectively. Univariate analysis revealed significant impact of histology, KPS, duration of symptoms and age on survival. KPS was found to be an independent prognostic factor according to multivariate analysis. These results were compared with literature.

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Cite This Article

GÜRKAYNAK, M., GENÇ, M., ZORLU, A. F., AKYOL, H. F., ATAHAN, İ. L. (2002). Results of conventionally fractionated radiotherapy in supratentorial malignant glioma patients. Turkish Journal of Cancer, Cilt: 32 - Sayı: 2, 41–47. https://ajindex.com/articles/368375

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References (13)

  1. Leibel SA, Sheline GE. Tolerance of the brain and spinal cord to conventional therapeutic irradiation. In: Gutin PH, Leibel SA, Sheline GA, editors. Radiation injury to the Nervous System. New York, NY: Raven,1991;239-56
  2. Walker MD, Green SB, Byar DP, et al. Randomized comparison of radiotherapy and nitrosoureas for the treatment of malignant glioma after surgery. N Engl J Med 1980;303:1323-9
  3. Prados MD, Gutin PH, Phillips TL, et al. Highly anaplastic astrocytoma: a review of 357 patients treated between 1977 and 1989. Int J Radiat Oncol Biol Phys 1992,23:3-8
  4. Curran WJ Jr, Scott CB, Horton J, et al. Does extent of surgery influence outcome for astrocytoma with atypical or anaplastic foci (AAF)? A report from three Radiation Therapy Oncology Group (RTOG) trials. J Neurooncol 1992;12:219-27
  5. Simpson JR, Horton J, Scott C, et al. Influence of location and extent of surgical resection on survival of patients with glioblastoma multiforme: Results of three consecutive Radiation Therapy Oncology Group (RTOG) clinical trials. Int J Radiat Oncol Biol Phys 1993;26:2239-44
  6. Zulch KJ. Histological typing of tumours of the central nervous system. (International Histological Classification of Tumours, No
  7. Geneva, World Health Organization, 1979
  8. Walker MD, Alexander E Jr, Hunt WE, et al. Evaluation of mithramycin in the treatment of anaplastic gliomas. J Neurosurg 1976;44:655-67
  9. Kristansen K, Hagen S, Kollevold T, et al. Combined modality therapy of operated astrocytomas Grade III and IV. Confirmation of the value of postoperative irradiation and lack of potentiation of bleomycin on survival: a prospective multicenter trial of the Scandinavian Glioblastoma Study Group. Cancer 1981;47:649-52
  10. Levin VA, Silver P, Hannigan J, et al. Superiority of post-radiotherapy chemotherapy with CCNU, Procarbazine and Vincristine (PCV) over BCNU for anaplastic gliomas: NCOG 6G61 final report. Int J Radiat Oncol Biol Phys 1990;18:321-4
  11. Leibel SA, Scott CB, Loeffler JS. Contemporary approaches to the treatment of malignant gliomas with radiation therapy. Semin Oncol 1994;21:198-219
  12. Chang CH, Horton J, Schoenfeld D, et al. Comparison of postoperative radiotherapy and combined postoperative radiotherapy and chemotherapy in the multidisciplinary management of malignant gliomas. A joint Radiation Therapy Oncology Group and Eastern Cooperative Oncology Group study. Cancer 1983;52:997-1007
  13. Brada M, Sharpe G, Balakrishnan R, et al. Modifying radic