This report describes a patient who developed distal acute arterial ischemia of the leg after first cycle of combined 5-fluorouracil (5-FU) and cisplatin chemotherapy regimen for recurrent squamous-cell carcinoma of the oral cavity.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:In recent years, the vascular toxicity of cancer chemotherapy drugs has become more widely appreciated.
📊
Key Findings & Data:Thrombosis is a well-known from of vascular toxicity of chemotherapy drugs and a frequent complication of cancer.
💡
Conclusion & Impact:This report describes a patient who developed distal acute arterial ischemia of the leg after first cycle of combined 5-fluorouracil (5-FU) and cisplatin chemotherapy regimen for recurrent squamous-cell carcinoma of the oral cavity.
In recent years, the vascular toxicity of cancer chemotherapy drugs has become more widely appreciated. Thrombosis is a well-known from of vascular toxicity of chemotherapy drugs and a frequent complication of cancer. The majority of thromboses occur in venous system; the incidence of arterial clots is much lower. This report describes a patient who developed distal acute arterial ischemia of the leg after first cycle of combined 5-fluorouracil (5-FU) and cisplatin chemotherapy regimen for recurrent squamous-cell carcinoma of the oral cavity.
ENGİN, H., ABALI, H., AKSOY, S., ÇELİK, İ. (2002). Acute arterial thrombosis related to 5-fluorouracil and cisplatin combination chemotherapy regimen in an elderly patient. Turkish Journal of Cancer, Cilt: 32 - Sayı: 2, 66–68. https://ajindex.com/articles/368368
Weiss RB, Tormey DC, Holland JF, et al. Venous thrombosis during multimodal treatment of primary breast carcinoma. Cancer Treat Rep 1981;65:677-9
Hansen SW, Olsen N, Rossing N, et al. Vascular toxicity and the mechanism underlying Raynaud’s phenomenon in patients treated with cisplatin, vinblastine and bleomycin. Ann Oncol 1990;1:289-92
McDonald GB, Hinds MS, Fisher LD, et al. Veno-occlusive disease of the liver and multiorgan failure after bone marrow transplantation: A cohort study of 355 patients. Ann Intern Med 1993;118:255-67
Gradishar W, Vokes E, Schilsky R, et al. Vascular events in patients receiving high-dose infusional 5-fluorouracil-based chemotherapy: the University of Chicago experience. Med Pediatr Oncol 1991;19:8-15
Cwikiel M, Albertsson M, Kinhult S, et al. 5-FU-induced small bowel toxicity in patients with colorectal carcinoma. Cancer 2000;89:711-2
Doll DC, List AF, Greco FA, et al. Acute vascular ischemic events after cisplatin combination chemotherapy for germ-cell tumors of the testis. Ann Intern Med 1986;105:48-51
Nichols CR. Testicular cancer. Curr Probl Cancer 1998;22:187-274
Berger CC, Bokemeyer C, Schuppert F. Endocrinological late effects after chemotherapy for testicular cancer. Br J Cancer 1996;73:1108-14
Barcelo R, Lopez-Vivanco G, Mane JM, et al. Distal ischemic changes related to combination chemotherapy with cisplatin and gemcitabine: Description of four cases. Ann Oncol 2000;11:1191-4.