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Journals / The Anatolian Journal of Cardiology / 2016 / Cilt: 16 - Sayı: 1

Assessment of left atrial appendage function during sinus rhythm in patients with obstructive sleep apnea

Mustafa GÖKHAN VURAL
SÜHA ÇETİN
Hüseyin GÜNDÜZ
Özge Özcan ABACIOĞLU
RAMAZAN AKDEMİR
Hikmet FIRAT
Ekrem YETER
Pages
34–41
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The evaluation of LAA mechanical function by tissue Doppler study using transthoracic echocardiography (TTE) may become an alternative for routine work-up in OSA patients

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Obstructive sleep apnea (OSA) is associated with thromboembolic events.
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Key Findings & Data:Compromised left atrial appendage (LAA) function due to left ventricular (LV) performance abnormality, often present in patients with OSA, may play an important role.
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Conclusion & Impact:The evaluation of LAA mechanical function by tissue Doppler study using transthoracic echocardiography (TTE) may become an alternative for routine work-up in OSA patients
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Obstructive sleep apnea (OSA) is associated with thromboembolic events. Compromised left atrial appendage (LAA) function due to left ventricular (LV) performance abnormality, often present in patients with OSA, may play an important role. The purpose of this study is to evaluate LV and LAA mechanical functions during sinus rhythm (SR) in patients with OSA.Methods: LV and LAA functions were assessed in 43 OSA patients and compared with that of 20 control patients in SR. Tissue Doppler velocities of the LAA apex and emptying velocities (EV) of LAA were obtained on parasternal short-axis view.Results: The baseline clinical characteristics were similar except for AHI (apnea-hypopnea index), minimal SaO, mean SaO, hypertension, and body-surface area. Most of the LV echocardiographic parameters significantly deteriorated in OSA patients in comparison with those in the control group. LAA EV, LAA systolic relaxation velocity (SM), LAA early-diastolic velocity (EM), LAA contraction velocity (AM), left atrial (LA) minimum volume index, LA ejection fraction, LA conduit volume index, and LA reservoir volume index were lower in OSA patients compared with those in the control group (p<0.05). LAA A was negatively correlated with AHI and the ratio of peak early diastolic flow velocity (E) to early-diastolic (E´) and positively correlated with LA conduit volume (p<0.05). Multiple predictors for LAA AM were AHI, presence of diastolic dysfunction, and E/E´ values (p<0.05).Conclusion: LAA mechanical function is significantly depressed in patients with OSA and SR. LAA dysfunction may predispose these patients to thromboembolic events. The evaluation of LAA mechanical function by tissue Doppler study using transthoracic echocardiography (TTE) may become an alternative for routine work-up in OSA patients

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Cite This Article

VURAL, M. G., ÇETİN, S., GÜNDÜZ, H., ABACIOĞLU, Ö. Ö., AKDEMİR, R., FIRAT, H., YETER, E. (2016). Assessment of left atrial appendage function during sinus rhythm in patients with obstructive sleep apnea. The Anatolian Journal of Cardiology, Cilt: 16 - Sayı: 1, 34–41. https://ajindex.com/articles/367258

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