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Journals / The Anatolian Journal of Cardiology / 2018 / Cilt: 19 - Sayı: 2

Decreased FENDRR and LincRNA-p21 expression in atherosclerotic plaque

NİLGÜN ÇEKİN
Arzu ÖZCAN
Sabahattin GÖKSEL
SERDAL ARSLAN
ERGÜN PINARBAŞI
Öcal BERKAN
Pages
131–136
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Our datamay provide helpful insights regarding the association of lncRNAs and atherosclerosis.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Cardiovascular diseases are the most important cause of mortality worldwide, particularly atherosclerosis.
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Key Findings & Data:Using RT-PCR, we investigated the role of two lncRNAs, FENDRR and LincRNA-p21, by comparing theirexpression levels in coronary artery plaques and normal mammary arteries of 20 atherosclerotic patients.Results: We found that the FENDRR and LincRNA-p21 expressions decreased by approximately 2 and 7 fold in coronary artery plaques, respectively,compared with those in IMA, which is known to have no plaque development.Conclusion: This study was the first to use mammary artery tissues of the same patients as a control and to study FENDRR expression.
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Conclusion & Impact:Our datamay provide helpful insights regarding the association of lncRNAs and atherosclerosis.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objective: Cardiovascular diseases are the most important cause of mortality worldwide, particularly atherosclerosis. Recently, lncRNAs affectingatherosclerotic progression have been reported in vascular smooth muscle cells, endothelial cells, and monocytes, suggesting that lncRNAsplay an important role in atherosclerosis.Methods: In recent clinical studies, nowadays, it was determined that internal mammary bypass grafts are closest to ideal grafts in coronaryartery bypass surgery. In this study, we used tissue samples taken from atherosclerotic coronary arteries and the internal mammary artery (IMA)during coronary artery bypass surgery. Using RT-PCR, we investigated the role of two lncRNAs, FENDRR and LincRNA-p21, by comparing theirexpression levels in coronary artery plaques and normal mammary arteries of 20 atherosclerotic patients.Results: We found that the FENDRR and LincRNA-p21 expressions decreased by approximately 2 and 7 fold in coronary artery plaques, respectively,compared with those in IMA, which is known to have no plaque development.Conclusion: This study was the first to use mammary artery tissues of the same patients as a control and to study FENDRR expression. Our datamay provide helpful insights regarding the association of lncRNAs and atherosclerosis.

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Cite This Article

ÇEKİN, N., ÖZCAN, A., GÖKSEL, S., ARSLAN, S., PINARBAŞI, E., BERKAN, Ö. (2018). Decreased FENDRR and LincRNA-p21 expression in atherosclerotic plaque. The Anatolian Journal of Cardiology, Cilt: 19 - Sayı: 2, 131–136. https://ajindex.com/articles/367223

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References (10)

  1. Xu T, Huang M, Xia R, Liu XX, Sun M, Yin L, et al. Decreased expression of the long non-coding RNA FENDRR is associated with poor prognosis in gastric cancer and FENDRR regulates gastric cancer cell metastasis by affecting fibronectin1 expression. J Hematol Oncol 2014; 7: 63. Alkemade FE, van Vliet P, Henneman P, van Dijk KW, Hierck BP, van Munsteren JC, et al. Prenatal Exposure to apoE Deficiency and Postnatal Hypercholesterolemia Are Associated with Altered CellSpecific Lysine Methyltransferase and Histone Methylation Patterns in the Vasculature. Am J Pathol 2010; 176: 542-8.
  2. Wierda RJ, Rietveld IM, van Eggermond MCJA, Belien JA, van Zwet EW, Lindeman JH, et al. Global histone H3 lysine 27 triple methylation levels are reduced in vessels with advanced atherosclerotic plaques. Life Sci 2015; 129: 3-9.
  3. Vausort M, Wagner DR, Devaux Y. Long Noncoding RNAs in patients with acute myocardial infarction. Circ Res 2014; 115: 668-77.
  4. Papait R, Kundurfranco P, Stirparo GG, Latronico MV, Condorelli G. Long noncoding RNA: a new player of heart failure? J Cardiovasc Transl Res 2013; 6: 876-83.
  5. Wu G, Cai J, Han Y, Chen J, Huang ZP, Chen C, et al. LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis and Atherosclerosis by Enhancing P53 Activity. Circulation 2014; 130: 1452-65.
  6. Huarte M, Guttman M, Feldser D, Garber M, Koziol MJ, Kenzelmann-Broz D, et al. A large intergenic noncoding RNA induced by p53 mediates global gene repression in the p53 response. Cell 2010; 142: 409-19.
  7. Grote P, Wittler L, Hendrix D, Koch F, Währisch S, Beisaw A, et al. The tissue-specific lncRNA Fendrr is an essential regulator of heart and body wall development in the mouse. Dev Cell 2013; 24: 206-14.
  8. Storino Farina M, Rojano Rada J, Molina Garrido A, Martínez X, Pulgar A, Paniagua R, et al. Statins and atherosclerosis: the role of epigenetics. Medwave 2015; 15: e6324. Guttman M, Rinn JL. Modular regulatory principles of large noncoding RNAs. Nature 2012; 482: 339-46. Hamilton JP. Epigenetics: principles and practice. Dig Dis 2011; 29: 130-5.
  9. Wierda RJ, Geutskens SB, Jukema JW, Quax PH, van den Elsen PJ. Epigenetics in atherosclerosis and inflammation. J Cell Mol Med 2010; 14: 1225-40. Libby P. Braunwald’s Heart Disease: A Textbook of Cardiovascular Medicine. Part VI, Chapter 41. Elsevier 2015; p.873-7.
  10. Thompson RC, Allam AH. Lombardi GP Wann LS, Sutherland ML, Sutherland JD et al. Atherosclerosis across 4000 years of human history: The Horus study of