Is the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome?

Only a significant association between a MetS severity of 5 and 4 with hs-CRP level was observed (p=0.028), whereas there was no statistically significant associationfor leukocyte count and NLR (p=0.246; p=0.643, respectively).Conclusion: NLR was not a good indicator of inflammation, while leukocyte and hs-CRP were more useful biomarkers to indicate inflammationin non-diabetic patients with obesity and MetS. (Anatol J Cardiol 2015; 15: 816-22)Keywords: metabolic syndrome, neutrophil-lymphocyte ratio, obesity, inflammation

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Obesity causes subclinical inflammation.

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Key Findings & Data:We aimed to investigate the usage of the neutrophil-lymphocyte ratio (NLR) as an inflammatory marker inobese patients with and without MetS.Methods: The study included a total of 1267 patients.

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Conclusion & Impact:Only a significant association between a MetS severity of 5 and 4 with hs-CRP level was observed (p=0.028), whereas there was no statistically significant associationfor leukocyte count and NLR (p=0.246; p=0.643, respectively).Conclusion: NLR was not a good indicator of inflammation, while leukocyte and hs-CRP were more useful biomarkers to indicate inflammationin non-diabetic patients with obesity and MetS. (Anatol J Cardiol 2015; 15: 816-22)Keywords: metabolic syndrome, neutrophil-lymphocyte ratio, obesity, inflammation

🔬Design:Research Article

📍Scope:2015 Verileri

⚙️Variables:Domain Parameters

Özet

Objective: Obesity causes subclinical inflammation. Leukocyte count and high-sensitivity C-reactive protein (hs-CRP) are used to indicateinflammation in clinical practice. Also, inflammatory markers are evaluated as important indicators of cardiovascular risk in patients with obesity and metabolic syndrome (MetS). We aimed to investigate the usage of the neutrophil-lymphocyte ratio (NLR) as an inflammatory marker inobese patients with and without MetS.Methods: The study included a total of 1267 patients. The patients were assigned groups according to degree of obesity and status of MetS.Metabolic and inflammatory markers were compared between groups, and correlation analysis was performed.Results: Leukocyte count and hs-CRP were significantly different (p<0.001), but NLR was not different between body mass index (BMI) groups(p=0.168). Both lymphocyte and neutrophil counts were significantly increased with increased degree of obesity (p<0.001, p=0.028, respectively). Leukocyte, neutrophil, and lymphocyte counts and hs-CRP level showed a significant correlation with BMI (r=0.198, p<0.001; r=0.163,p<0.001; r=0.167, p<0.001; r=0.445, p<0.001, respectively), whereas NLR was not correlated with BMI (r=0.017, p=0.737). Only a significant association between a MetS severity of 5 and 4 with hs-CRP level was observed (p=0.028), whereas there was no statistically significant associationfor leukocyte count and NLR (p=0.246; p=0.643, respectively).Conclusion: NLR was not a good indicator of inflammation, while leukocyte and hs-CRP were more useful biomarkers to indicate inflammationin non-diabetic patients with obesity and MetS. (Anatol J Cardiol 2015; 15: 816-22)Keywords: metabolic syndrome, neutrophil-lymphocyte ratio, obesity, inflammation

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Cite This Article

BAHADIR, A., BALTACI, D., TÜRKER, Y., TÜRKER, Y., ILİEV, D., ÖZTÜRK, S., DELER, M. H., SARIGÜZEL, Y. C. (2015). Is the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome?. The Anatolian Journal of Cardiology, Cilt: 15 - Sayı: 10, 816–822. https://ajindex.com/articles/365884

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