AI Summary & Key Takeaways
AI InsightSACP is a superior neuroprotective strategy for both mild andprolonged DHCA.
📌 3 Key Takeaways
Özet
Objective: The aim of this study was to elucidate the mechanism of cerebral injury and to evaluate selective antegrade cerebral perfusion(SACP) as a superior neuroprotective strategy for prolonged deep hypothermic circulatory arrest (DHCA).Methods: Twelve pigs (6–8-week old) were randomly assigned to DHCA alone (n=6) and DHCA with SACP (n=6) at 18°C for 80 min groups. SerumS100 was determined using an immunoassay analyzer. The concentrations of cerebral dialysate glucose, lactate, pyruvate, glycerol, and glutamatewere measured using a microdialysis analyzer.Results: Compared with a peak at T4 (after 60 min of rewarming) in the DHCA group, the serum S100 in the SACP group was significantly lowerthroughout the study. The DHCA group was susceptible to significant increases in the levels of lactate, glycerol, and glutamate and the ratioof lactate/pyruvate as well as decreases in the level of glucose. These microdialysis variables showed only minor changes in the SACP group.There was a positive correlation between cerebral lactate and intracranial pressure during reperfusion in the DHCA group. However, the apoptosisindex and C-FOS protein levels were lower in the SACP group.Conclusion: Metabolic dysfunction is involved in the mechanism of cerebral injury. SACP is a superior neuroprotective strategy for both mild andprolonged DHCA.